scholarly journals Is HO-YAG Laser in Perianal Warts Safe in Children? A Report of 3 Cases

2021 ◽  
pp. 1-4
Author(s):  
Merve Altin Gulburun ◽  
Hayrunnisa Oral ◽  
Sibel Eryilmaz ◽  
Cem Kaya ◽  
Ramazan Karabulut ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Skin Disease ◽  
Hpv Infection ◽  
Yag Laser ◽  
Verruca Vulgaris ◽  
Anogenital Region ◽  
Common Skin ◽  
Uncommon Location

Verruca Vulgaris or wart is a common skin disease caused by human papillomavirus (HPV) infection. Warts are usually located on fingers, hands, elbows and feet. Anogenital region is an uncommon location for warts.  Three children with large perianal warts were treated by holmium: Yttrium Aliminum Garnet (Ho-YAG) laser. No recurrences or significant complications were seen in 2 years of  follow up period.  Ho-YAG Laser was successfully applied in the treatment of pediatric perianal warts. It is a safe and effective method.

scholarly journals Genome-Wide Association Study of Prevalent and Persistent Cervical High-Risk Human Papillomavirus(HPV) Infection

2019 ◽  
Author(s):  
Sally N. Adebamowo ◽  
Adebowale A Adeyemo ◽  
Charles N Rotimi ◽  
Olayinka Olaniyan ◽  
Richard B. Offiong ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Principal Component ◽  
Hpv Infection ◽  
Genome Wide Association ◽  
Replication Studies ◽  
Genome Wide

Abstract Background: Genetic factors may influence the susceptibility to high-risk human papillomavirus (hrHPV) infection and persistence. We conducted the first genome-wide association study (GWAS) to identify variants associated with cervical hrHPV infection and persistence. Methods: Participants were 517 Nigerian women evaluated at baseline and 6 months follow-up visits for HPV. HPV was characterized using SPF10/LiPA25. hrHPV infection was positive if at least one carcinogenic HPV genotype was detected in a sample provided at the baseline visit and persistent if at least one carcinogenic HPV genotype was detected in each of the samples provided at the baseline and follow-up visits. Genotyping was done using the Illumina Multi-Ethnic Genotyping Array (MEGA) and imputation was done using the African Genome Resources Haplotype Reference Panel. Association analysis was done under additive genetic models adjusted for age, HIV status and the first principal component (PC) of the genotypes. Results: The mean (±SD) age of the study participants was 38 (±8) years, 48% were HIV negative, 24% were hrHPV positive and 10% had persistent hrHPV infections. The top three variants associated with hrHPV infections were intronic variants clustered in KLF12 (all OR: 7.06, p=1.43 x 10-6). The top variants associated with cervical hrHPV persistence were in DAP(OR: 6.86, p=7.15 x 10-8), NR5A2(OR: 3.65, p=2.03 x 10-7) and MIR365-2(OR: 7.71, p=2.63 x 10-7) gene regions. Conclusions: This exploratory GWAS yielded novel candidate risk loci for cervical hrHPV infection and persistence. The identified loci have biological annotation and functional data supporting their role in hrHPV infection and persistence. Given our limited sample size, larger discovery and replication studies are warranted to further characterize the reported associations.

scholarly journals PROFIL VERUKA VULGARIS DI POLIKLINIK KULIT DAN KELAMIN RSUP PROF. DR. R. D. KANDOU MANADO PERIODE JANUARI - DESEMBER 2013

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Preisy G. I. Tampi ◽  
Ferra O. Mawu ◽  
Nurdjannah J. Niode
Keyword(s):  
Young Adults ◽  
Human Papillomavirus ◽  
Retrospective Study ◽  
Squamous Epithelium ◽  
Hpv Infection ◽  
Indirect Contact ◽  
Verruca Vulgaris ◽  
Common Warts ◽  
Children And Young Adults

Abstract: Verruca vulgaris (common warts) is a benign proliferation of squamous epithelium caused by Human papillomavirus (HPV) infection, especially type 2 and 1. Verruca vulgaris can occur at any age, but more often among children and young adults. Warts are spread by direct or indirect contact. The lesions appear most commonly in areas affected by trauma such as the hands, fingers, elbows, and knees, albeit, they can occur in other places. This study aimed to determine the profile of verruca vulgaris in Dermatovenereology Clinic of Prof. Dr. R. D. Kandou Hospital Manado period January – December 2013. This was a retrospective study based on gender, age, occupation, location of the lesion, and therapy. The results showed that of 4099 new cases there were 43 cases of verruca vulgaris (1.05%), most were females (51.16%), and aged 5-14 years (30.22%). They were commonly students (32.56%), the location of lesion at the upper extremity (32.56%), and the treatment of the lesion with electrical surgery (93.02%). Keywords: verruca vulgaris Abstrak: Veruka vulgaris (common warts atau kutil) adalah proliferasi jinak epitel skuamous yang disebabkan oleh infeksi Human Papillomavirus (HPV), terutama tipe 2 dan 1. Veruka vulgaris dapat menyerang semua kelompok usia, tetapi lebih sering pada anak dan dewasa muda. Penyebaran virus ini dapat melalui kontak langsung maupun secara tidak langsung. Veruka sering timbul pada daerah yang terkena trauma seperti tangan, jari, siku dan lutut, namun dapat timbul di mana saja pada kulit. Penelitian ini bertujuan untuk mengetahui profil veruka vulgaris di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode Januari-Desember 2013. Penelitian ini bersifat deskriptif retrospektif dengan variabel jenis kelamin, umur, pekerjaan, lokasi lesi, dan penatalaksanaan. Hasil penelitian menunjukkan bahwa dari 4099 kasus baru terdapat 43 kasus veruka vulgaris (1,05%), terbanyak ialah pasien perempuan (51,16%), dengan kelompok umur 5-14 tahun (30,22%), terbanyak pada siswa (32,56%), lokasi lesi ekstremitas atas (32,56%), dan penatalaksanaan lesi dengan bedah listrik (93,02%).Kata kunci: veruka vulgaris

Human Papillomavirus Infection and Prevention In The Adolescent

2020 ◽  
Author(s):  
Alexandria Richards ◽  
Joanna Stacey
Keyword(s):  
Human Papillomavirus ◽  
Hpv Vaccination ◽  
Transmitted Disease ◽  
Cervical Dysplasia ◽  
Vaccine Safety ◽  
Genital Warts ◽  
Hpv Infection ◽  
Sexually Transmitted ◽  
Papillomavirus Infection

Human papillomavirus, or HPV, is a common sexually transmitted disease, most often acquired during the adolescence or the early 20s. It can be divided into oncogenic and nononcogenic serotypes. It is responsible for genital warts as well as pathologic diseases that can lead to genital cancers and cancers of the oropharyngeal tract in both males and females. The majority of adolescents who acquire HPV infections do not go on to develop cancer. New discoveries about the virus’ persistence and latency direct how we treat adolescents with HPV infections. Recommendations for prevention of HPV include use of the 9-valent vaccine against the most common oncogenic HPV serotypes. Screening should be delayed until the age of 21, with the exception of immunocompromised women. The HPV vaccination is safe and effective, and does not encourage sexual activity among adolescents. Both boys and girls should be vaccinated against HPV at 11 to 12 years of age but may receive the vaccination as early as 9 or as late as 21 (males) or 26 (females) years of age. The vaccine may now also be given in only two doses if the series was started before the age of 15. Follow-up studies in the years after the vaccine’s introduction have shown large decreases in HPV infection rates. This review contains 7 figures, 7 tables and 63 references Key Words: Oncogenic subtype, Oropharyngeal cancer, Infection persistence, Immune tolerance, Cervical dysplasia, Genital warts, 9-valent vaccine, Vaccine safety  

Abstract 551: Human papillomavirus (HPV) infection characteristics in a cohort of men who have sex with men (MSM) during long-term follow-up

2012 ◽  
Author(s):  
Dorothy J. Wiley ◽  
Xiuhong Li ◽  
Hilary K. Hsu ◽  
Stephen Young ◽  
Ross D. Cranston ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Hpv Infection ◽  
Long Term Follow Up ◽  
Sex With Men

scholarly journals Genome-wide association study of prevalent and persistent cervical high-risk human papillomavirus (HPV) infection

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Sally N. Adebamowo ◽  
◽  
Adebowale A. Adeyemo ◽  
Charles N. Rotimi ◽  
Olayinka Olaniyan ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Principal Component ◽  
Hpv Infection ◽  
Genome Wide Association ◽  
Replication Studies ◽  
Genome Wide

Abstract Background Genetic factors may influence the susceptibility to high-risk (hr) human papillomavirus (HPV) infection and persistence. We conducted the first genome-wide association study (GWAS) to identify variants associated with cervical hrHPV infection and persistence. Methods Participants were 517 Nigerian women evaluated at baseline and 6 months follow-up visits for HPV. HPV was characterized using SPF10/LiPA25. hrHPV infection was positive if at least one carcinogenic HPV genotype was detected in a sample provided at the baseline visit and persistent if at least one carcinogenic HPV genotype was detected in each of the samples provided at the baseline and follow-up visits. Genotyping was done using the Illumina Multi-Ethnic Genotyping Array (MEGA) and imputation was done using the African Genome Resources Haplotype Reference Panel. Association analysis was done for hrHPV infection (125 cases/392 controls) and for persistent hrHPV infection (51 cases/355 controls) under additive genetic models adjusted for age, HIV status and the first principal component (PC) of the genotypes. Results The mean (±SD) age of the study participants was 38 (±8) years, 48% were HIV negative, 24% were hrHPV positive and 10% had persistent hrHPV infections. No single variant reached genome-wide significance (p < 5 X 10− 8). The top three variants associated with hrHPV infections were intronic variants clustered in KLF12 (all OR: 7.06, p = 1.43 × 10− 6). The top variants associated with cervical hrHPV persistence were in DAP (OR: 6.86, p = 7.15 × 10− 8), NR5A2 (OR: 3.65, p = 2.03 × 10− 7) and MIR365–2 (OR: 7.71, p = 2.63 × 10− 7) gene regions. Conclusions This exploratory GWAS yielded suggestive candidate risk loci for cervical hrHPV infection and persistence. The identified loci have biological annotation and functional data supporting their role in hrHPV infection and persistence. Given our limited sample size, larger discovery and replication studies are warranted to further characterize the reported associations.

Persistence of human papillomavirus as a predictor for treatment failure after loop electrosurgical excision procedure

2007 ◽  
Vol 17 (6) ◽  
pp. 1271-1277 ◽  
Author(s):  
J. H. Bae ◽  
C. J. Kim ◽  
T. C. Park ◽  
S. E. Namkoong ◽  
J. S. Park
Keyword(s):  
Human Papillomavirus ◽  
Treatment Failure ◽  
Significant Risk ◽  
Hpv Infection ◽  
Dna Chip ◽  
Hpv Dna ◽  
Hpv Test ◽  
Loop Electrosurgical Excision ◽  
Loop Electrosurgical Excision Procedure

We aimed to investigate whether postconization human papillomavirus (HPV) DNA testing can predict treatment failure and improve the accuracy of conventional follow-up in women with high-grade cervical intraepithelial neoplasia (CIN). Between March 2001 and October 2005, 120 patients with confirmed CIN 2 or 3 were treated with loop electrosurgical excision procedure (LEEP) and were enrolled. Six patients were lost to the follow-up. Postconization follow-up was performed at every 3–6 months during the first year and then annually. Specimens were tested for the presence of HPV, using the Hybrid Capture 2 (Digene Co, Gaithersburg, MD) and HPV DNA chip (Mygene Co, Seoul, Korea) test. Persistent HPV infection was defined as persistently (two times or more) positive HPV tests with the same HPV subtype(s) at initial diagnosis. Twenty-two (19.3%) patients showed treatment failure after conization. The only significant risk factor for redevelopment of CIN after conization was persistence of the same HPV subtype (P< 0.0001). And women with recurrent or residual CIN had higher HPV load during the 6-month follow-up postconization. In conclusion, the persistence of the same HPV subtype after LEEP conization was an important predictor of treatment failure. The follow-up protocol after conization of CIN should include both cervical cytology and HPV test, and HPV DNA chip test is needed to detect a persistent HPV infection.

scholarly journals Persistence or Clearance of Human Papillomavirus Infections in Women in Ouro Preto, Brazil

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
P. M. Miranda ◽  
N. N. T. Silva ◽  
B. C. V. Pitol ◽  
I. D. C. G. Silva ◽  
J. L. Lima-Filho ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Risk Groups ◽  
Health Department ◽  
Hpv Infection ◽  
Behavioral Characteristics ◽  
Precursor Lesions ◽  
Papillomavirus Infections ◽  
Behavioral Information

Persistent high-risk (HR) human papillomavirus (HPV) infection is necessary for development of precursor lesions and cervical cancer. We investigate persistence and clearance of HPV infections and cofactors in unvaccinated women. Cervical samples of 569 women (18–75 years), received for routine evaluation in the Health Department of Ouro Preto, Brazil, were collected and subjected to PCR (MY09/11 or GP5+/6+ primers), followed by RFLP or sequencing. All women were interviewed to collect sociodemographic and behavioral information. Viral infection persistence or clearance was reevaluated after 24 months and was observed in 59.6% and 40.4% of women, respectively. HPVs 16, 33, 59, 66, 69, and 83 (HR) were the most persistent types whereas HPVs 31, 45, and 58 were less persistent. Clearance or persistence did not differ between groups infected by HPVs 18, 53, and 67. In low-risk (LR) types, HPV 6 infected samples were associated with clearance, while HPV 11, 61, 72, or 81 infected samples were persistent in the follow-up. No statistically significant association was detected between persistent HPV infections and sociodemographic and behavioral characteristics analyzed. To study persistence or clearance in HPV infection allows the identification of risk groups, cofactors, and strategies for prevention of cervical cancer.

scholarly journals Is stress related to the presence and persistence of oncogenic human papillomavirus infection in young women?

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ulrike Kuebler ◽  
Susanne Fischer ◽  
Laura Mernone ◽  
Christian Breymann ◽  
Elvira Abbruzzese ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Chronic Stress ◽  
Salivary Cortisol ◽  
Positive Association ◽  
Hpv Infection ◽  
Cortisol Awakening Response ◽  
Diurnal Cortisol ◽  
Papillomavirus Infection ◽  
Hpv Status

Abstract Background Persistent infection with high-risk human papillomavirus (HR-HPV) is the most important risk factor for the development of cervical cancer, but factors contributing to HR-HPV persistence are incompletely understood. The objective of this study was to test for associations of chronic stress and two aspects of diurnal cortisol secretion (i.e., the cortisol awakening response [CAR] and total cortisol output over the day [AUCgday]) with HR-HPV status at baseline and 12 months later (follow-up). Methods We evaluated 188 women (25 ± 3 years) at baseline. Follow-up investigation was restricted to HR-HPV infected women at baseline. Of the initial 48 HR-HPV positive participants, 42 completed the follow-up (16 HR-HPV positive and 26 HR-HPV negative). At baseline and follow-up, we determined HR-HPV status in cervical smears, assessed chronic stress, and repeatedly measured salivary cortisol over the day. At baseline, we analyzed salivary cortisol only in a subgroup of 90 participants (45 HR-HPV negative and 45 HR-HPV positive). Results At baseline, higher chronic stress (excessive demands at work: p = .022, chronic worrying: p = .032), and a higher CAR (p = .014) were related to baseline HR-HPV positivity. At follow-up, there was a statistical trend for a positive association between the CAR and HR-HPV positivity (p = .062). Neither the CAR nor the AUCgday mediated the associations between chronic stress and HR-HPV status. Conclusions Our findings suggest that both chronic stress and diurnal cortisol are related to the presence of HR-HPV infection and may thus play a role in HPV-associated cervical carcinogenesis.

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