Practical Manual for Herbal Drug Technology

Standardization of drugs refers to the confirmation of its identity and determination of the quality and purity. Herbal drug technology is used for converting botanical materials into medicines, where standardization and quality control with proper integration of modern scientific techniques and traditional knowledge are important. However, the quality control and quality assurance still remains a challenge because of the high variability of chemical components involved. Most of the pharmaceutical industries are using substitute drugs in place of authentic drugs. So to manufacture and deliver the best quality drugs, it is essential to authenticate the raw drugs. Keeping the current inclination in mind, Varnyadravya or the complexion promoting drugs such as Yashtimadhu (Glycirrhizia glabra) and Manjishtha (Rubia Cordifolia) churna were subjected for standardization procedures. From the current study, genuinity indicating parameters for both Yashtimadhu churna (powder) and Manjishthachurna were derived.

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Standardization of Dhatryadi Ghrita: A Herbal Ghee Based Ayurvedic Medicinal Preparation

Open Medicine Journal ◽

10.2174/1874220301805010047 ◽

2018 ◽

Vol 5 (1) ◽

pp. 47-55 ◽

Cited By ~ 3

Author(s):

Rashmi Saxena Pal ◽

Amrita Mishra

Keyword(s):

Herbal Medicines ◽

Medicinal Preparation ◽

Preliminary Test ◽

Systematic Research ◽

Herbal Drugs ◽

Herbal Drug ◽

Current Time ◽

Physico Chemical ◽

Regulatory Bodies ◽

Drug Technology

Background:In the current time, there is a need to thoroughly examine the process of systematic research methodology and to provide genuine findings to provide the reference for further investigations of traditional herbal medicines, which are beneficial for various disorders.Objectives:To standardize Dhatryadi Ghrita on various parameters, in order to assure its safety and efficacy on various grounds.Methods:The Ghrita was analyzed for its organoleptic, physico-chemical features and screened for its phyto-constituents as well as its chromatographic analysis.Results:The physicochemical standards would serve as a preliminary test for the standardization of the formulation, which helps to lay standards for further use as reference for the quality control/quality assurance laboratory of a Pharmaceutical house.Conclusion:The improvement of analytical methodologies can serve as a specific basis for research in herbal drug technology, thereby, facilitating the producers and researchers to set quality standards as well as parameters, so as to fulfill the requirements of regulatory bodies for the establishment of therapeutic efficacy, safety and purity of herbal drugs. The obtained values can be adopted to lay down new pharmacopoeial standards to be followed in its preparation with batch to batch consistency.

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The effects of the multi-herbal drug STW5 on intestinal inflammation and motility

Planta Medica ◽

10.1055/s-0036-1596950 ◽

2016 ◽

Vol 81 (S 01) ◽

pp. S1-S381

Author(s):

L Marx ◽

D Grundmann ◽

D Schreiber ◽

D Simon ◽

A Braun ◽

...

Keyword(s):

Intestinal Inflammation ◽

Herbal Drug

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Comparing Effectiveness of a Combined Herbal Drug Based on Echium Amoenum with Citalopram in the Treatment of Major Depressive Disorder

Current Drug Discovery Technologies ◽

10.2174/1570163815666180219115844 ◽

2019 ◽

Vol 16 (2) ◽

pp. 232-238 ◽

Cited By ~ 2

Author(s):

Majid Anushiravani ◽

Ali A. Manteghi ◽

Ali Taghipur ◽

Mahdi Eslami

Keyword(s):

Randomized Controlled Trial ◽

Major Depressive Disorder ◽

Depressive Disorder ◽

Controlled Trial ◽

Herbal Drug ◽

Medical Sciences ◽

Major Depressive ◽

Dsm 5 ◽

Randomized Controlled ◽

Echium Amoenum

Background: According to new studies, only 60% of depressed patients respond to pharmaceutical treatment while suffering from their side effects. Natural products as adjuvant or alternative therapies should be examined to find safer and more effective ways to cope with depression. Objective: To find out the potential benefits of a combined herbal drug based on Echium amoenum compared with citalopram in the treatment of Major Depressive Disorder. Design and Setting: In psychiatry clinics of Mashhad University of Medical Sciences, 50 patients who met the criteria for Major Depressive Disorder based on DSM-5 were studied in a parallel randomized controlled trial. Design and Setting: In psychiatry clinics of Mashhad University of Medical Sciences, 50 patients who met the criteria for Major Depressive Disorder based on DSM-5 were studied in a parallel randomized controlled trial. Intervention: Subjects were randomly assigned to receive Echium amoenum compound syrup (EACS) or citalopram tablet for 8 weeks. Outcome Measures: The efficacy of treatments and recurrence of disease were surveyed and compared according to Hamilton depression rating scale at weeks 0, 4, 8, 12. Results: Patients in both groups of citalopram and EACS showed remarkable reduction in scores of Hamilton questionnaire. At the eighth week of treatment, the mean scores in EACS group were significantly lower than citalopram group (p-value = 0.03). 52% of patients suffered from various complications in citalopram group while just 12% of patients in EACS group reported few complications. Conclusion: Clinical efficacy of this herbal drug was significantly higher than citalopram, and complications were also less and lower in EACS group. Further studies with larger groups and para-clinical assessments such as serologic tests and QEEG would improve our understanding of the impacts and mechanisms of EACS.

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Nanoemulsions- A better Approach for Anti Diabeticdrugs Delivering

Current Diabetes Reviews ◽

10.2174/1573399817666201209095205 ◽

2020 ◽

Vol 17 ◽

Author(s):

V. Manimaran ◽

Ponnurengam Malliappan Sivakumar ◽

J. Narayanan ◽

Shanmugam Parthasarathi ◽

Pranav Kumar Prabhakar

Keyword(s):

Aqueous Phase ◽

Therapeutic Agent ◽

Antidiabetic Drugs ◽

Optical Behaviour ◽

Antimicrobial Drugs ◽

Drug Degradation ◽

Oil In Water ◽

Drug Technology ◽

Human Use ◽

Poor Absorption

: Conventional delivery of antidiabetic drugs faces many problems like poor absorption, low bioavailability, and drug degradation. Nanoemulsion is a unique drug technology which is very suitable for the delivery of antidiabetic drugs. In recent years the flaws of delivering anti-hypoglycaemic drugs have been overcome by choosing nanoemulsion drug technology. They are thermodynamically stable and also deliver the therapeutic agent for a longer duration. Generally, Nanoemulsions are made up of either oil-in-water or water-in-oil and size of the droplets is from fifty to thousand nanometer. Surfactants are critical substances which are added in the manufacturing of nanoemulsions. Only the surfactants which are approved for human use can be utilized in the manufacturing of nanoemulsions. Generally, the preparation of emulsions includes mixing of the aqueous phase and organic phase and using surfactant with proper agitation. Nanoemulsions are used for antimicrobial drugs, and they are also used in the prophylaxis of cancer, diabetics. Reduction in the droplet size may cause variation in the elastic and optical behaviour of nanoemulsions.

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