scholarly journals Cord Blood Haematological Profiling Study: Predictive Markers of Neonatal Health Status at Birth in Anyigba, North Central Nigeria

2021 ◽  
pp. 33-39
Author(s):  
Shedrack Egbunu Akor ◽  
Dickson Achimugu Musa ◽  
S. P. O. Akogu ◽  
Akpa Matthew ◽  
Adeyemi Alapo Funmilola ◽  
...  
Keyword(s):  
Health Status ◽  
Cord Blood ◽  
Neonatal Mortality ◽  
Umbilical Cord ◽  
Teaching Hospital ◽  
Umbilical Cord Blood ◽  
University Teaching ◽  
Haematological Parameters ◽  
State University ◽  
North Central

Background: Neonatal mortality refers to the death of a live-born babies within the first 28 days of life remains a global public health challenge. Cord blood being the medium of communication, transmission of nutrients and wastes between mothers and fetus can reflect the health status of baby at birth if properly utilized. Owing to multiple factors involved in neonatal mortality, this study used umbilical cord blood haematological parameters to ascertain the health status of neonates at birth, the aim of this study is to use umbilical cord blood haematological parameters for management of neonates at birth. Methodology: This research is a cross-sectional study carried out at the Departments of Obstetrics and Gynaecology and Medical Laboratory Department, Kogi State University Teaching Hospital, Anyigba, North Central Nigeria between January, and December, 2020.  Cord blood from 164 babies delivered in Kogi State University Teaching Hospital, Grimard Catholic Hospital, and Amazing Grace Hospital between January and December, 2020 were analyzed for haematological parameters using Sysmex XP-300 automated haematology analyzer. The data obtained were expressed as mean ±standard deviation using SPSS statistical software, version 23.0. The indicator level of statistical significance was set at p<0.05. Results: The results showed significant increase (p<0.05) of WBC, RBC, MCV, MCH and MCHC in unstable babies compared to the stable babies, significant decrease (p<0.05) in the platelets, neutrophil and mixed among unstable babies compared to the stable babies, but no significant difference in PCV,  haemoglobin and lymphocyte counts of both stable and unstable babies. The results also demonstrated 25 deaths per 1000 live newborn neonates within 48hour during the period of study. Conclusion: This study shows that cord blood haematological parameters at birth can be used to ascertain the health status of neonates.

scholarly journals Determination of lead levels in maternal and umbilical cord blood at birth at the Lagos University Teaching Hospital, Lagos

PLoS ONE ◽  
2019 ◽  
Vol 14 (2) ◽  
pp. e0211535 ◽  
Author(s):  
Jejelola I. Ladele ◽  
Iretiola Bamikeolu Fajolu ◽  
Veronica Chinyere Ezeaka
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Teaching Hospital ◽  
Umbilical Cord Blood ◽  
University Teaching ◽  
Lead Levels

scholarly journals Laboratory Characteristics of Umbilical Cord Blood in Makurdi North-Central Nigeria

2018 ◽  
Vol 1 (4) ◽  
pp. 228-233
Author(s):  
A I Nwannadi ◽  
T Z Swende ◽  
O O Alao ◽  
H I Aba ◽  
M A Onoja ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Reference Values ◽  
Umbilical Cord Blood ◽  
Blood Count ◽  
Haemoglobin Concentration ◽  
Haematological Parameters ◽  
White Blood Count ◽  
Reference Ranges ◽  
Distribution Method

Umbilical cord blood (UCB) which is useful in supportive and definitive management of inherited and acquired disorders is usually discarded in our environment. We sought to establish reference values for some haematological parameters of UCB in Makurdi, Nigeria to assist clinicians better interpret results of haematological parameters of UCB. This was a prospective quantitative study that involved analyzing UCB of qualified women to determine its complete blood count, fetal haemoglobin concentration, clotting profile and fibrinogen concentration. Reference ranges of these parameters were thereafter calculated using normal distribution method. The effects of maternal and fetal factors on these parameters were assessed using the Student t-test and ANOVA. The mean total white blood count (TWBC) was 12.3±3.7 x 109/L. Female births had significantly higher TWBC than male births (13.2 ± 3.3 x 109/L vs 11.0 ± 3.8 x 109/L, p=0.003). Babies that weighed 3.0-3.5kg also had significantly higher TWBC (18.9x109L) than those that weighed 2.4-2.9kg (8.7x109/L) p=0.010.Female births had significantly higher haemoglobin concentration (Hb) (13.9g/dl) than male births (11.9g/dl) p=0.001. Similarly, older women aged 32-41 years had significantly higher Hb (13.4g/dl) than those aged 18-24 years (11.6g/dl) p=0.002. Also, women that had more than two children had higher Hb than those who had one or two, (14.7g/dl vs 12.3g/dl) p=0.030. Babies that weighed 3.0-3.5kg at birth also had significantly higher Hb (16.2g/dl) than babies that weighed 2.4-2.9kg (12.3g/dl), p=0.003.The reference values of the haematological parameters of cord blood in our study were similar to what was reported from other developing countries. This study has provided data on haematological parameters of UCB for clinical use in our environment and we recommend routine UCB analysis in order to aid early detection of some inherited and congenital disorder.

scholarly journals Prooxidant-Antioxidant Balance in Umbilical Cord Blood of Infants with Meconium Stained of Amniotic Fluid

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Mohammad Hassan Arjmand ◽  
Farhat Ahmad Shah ◽  
Masoud Saleh Moghadam ◽  
Fatemeh Tara ◽  
Amin Jalili ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Amniotic Fluid ◽  
Cord Blood ◽  
Neonatal Mortality ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Meconium Aspiration Syndrome ◽  
Meconium Aspiration ◽  
Mortality And Morbidity ◽  
Healthy Infants

Objective. Using a novel assay termed prooxidant-antioxidant balance (PAB) assay to determine prooxidant-antioxidant balance in umbilical cord blood of infants with meconium stained of amniotic fluid (MSAF). Passage of meconium in amniotic fluid is associated with increase of neonatal mortality and morbidity. This complication occurs in about 15% of infants and is more widespread in postterm neonates. About 1.5 percent of neonates with MSAF develop meconium aspiration syndrome.Method. Sera of 29 umbilical cord blood of infants with MSAF and 32 healthy infants (HI) were collected. Both groups had nonsmoker and non-alcoholic mothers with no diseases. The PAB was measured.Result. There was a significant increase of PAB value (32.8±15.9 HK) in umbilical cord blood of infants with MSAF in comparison to HI (24.5±12.6 HK) (P<0.05). There was no significant correlation between PAB value and age of mothers.Conclusion. The increased PAB value in infants with MSAF showed that these infants are exposed to oxidative stress. Further research with larger population is needed to demonstrate the oxidative stress in infants with MSAF.

scholarly journals Laboratory Characteristics of Umbilical Cord Blood in Makurdi North-Central Nigeria

2018 ◽  
Vol 1 (4) ◽  
pp. 228-233
Author(s):  
A I Nwannadi ◽  
T Z Swende ◽  
O O Alao ◽  
H I Aba ◽  
M A Onoja ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Reference Values ◽  
Umbilical Cord Blood ◽  
Blood Count ◽  
Haemoglobin Concentration ◽  
Haematological Parameters ◽  
White Blood Count ◽  
Reference Ranges ◽  
Distribution Method

Umbilical cord blood (UCB) which is useful in supportive and definitive management of inherited and acquired disorders is usually discarded in our environment. We sought to establish reference values for some haematological parameters of UCB in Makurdi, Nigeria to assist clinicians better interpret results of haematological parameters of UCB. This was a prospective quantitative study that involved analyzing UCB of qualified women to determine its complete blood count, fetal haemoglobin concentration, clotting profile and fibrinogen concentration. Reference ranges of these parameters were thereafter calculated using normal distribution method. The effects of maternal and fetal factors on these parameters were assessed using the Student t-test and ANOVA. The mean total white blood count (TWBC) was 12.3±3.7 x 109/L. Female births had significantly higher TWBC than male births (13.2 ± 3.3 x 109/L vs 11.0 ± 3.8 x 109/L, p=0.003). Babies that weighed 3.0-3.5kg also had significantly higher TWBC (18.9x109L) than those that weighed 2.4-2.9kg (8.7x109/L) p=0.010.Female births had significantly higher haemoglobin concentration (Hb) (13.9g/dl) than male births (11.9g/dl) p=0.001. Similarly, older women aged 32-41 years had significantly higher Hb (13.4g/dl) than those aged 18-24 years (11.6g/dl) p=0.002. Also, women that had more than two children had higher Hb than those who had one or two, (14.7g/dl vs 12.3g/dl) p=0.030. Babies that weighed 3.0-3.5kg at birth also had significantly higher Hb (16.2g/dl) than babies that weighed 2.4-2.9kg (12.3g/dl), p=0.003.The reference values of the haematological parameters of cord blood in our study were similar to what was reported from other developing countries. This study has provided data on haematological parameters of UCB for clinical use in our environment and we recommend routine UCB analysis in order to aid early detection of some inherited and congenital disorder.

Clinico-pathological characteristics of Skin Cancers at Benue State University Teaching Hospital, Makurdi, North Central Nigeria

2016 ◽  
Vol 12 (2) ◽  
pp. 56 ◽  
Author(s):  
ChukwukadibiaN Ahachi ◽  
PriscillaDenen Akaa ◽  
ItodoC Elachi ◽  
DanielD Mue ◽  
JosephA Ngbea ◽  
...  
Keyword(s):  
Teaching Hospital ◽  
University Teaching ◽  
State University ◽  
North Central ◽  
Pathological Characteristics ◽  
Skin Cancers

scholarly journals Haematological parameters and coagulation in umbilical cord blood following COVID-19 infection in pregnancy

2021 ◽  
Vol 266 ◽  
pp. 99-105
Author(s):  
Claire A. Murphy ◽  
Daniel P. O'Reilly ◽  
Osasere Edebiri ◽  
Luisa Weiss ◽  
Sarah Cullivan ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Haematological Parameters ◽  
In Pregnancy
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