scholarly journals Gastro-intestinal Stromal Tumor Complicated by an Acute Intestinal Occlusion: A Case Report

2021 ◽  
pp. 12-17
Author(s):  
A. Elbakouri ◽  
A. Zouhair ◽  
F. Z. Bensardi ◽  
M. Bouali ◽  
K. Elhattabi ◽  
...  
Keyword(s):  
Radical Surgery ◽  
Abdominal Mass ◽  
Tumour Mass ◽  
Gastrointestinal Stromal Tumours ◽  
Variable Size ◽  
Stromal Tumors ◽  
Clinical Symptomatology ◽  
Metastatic Gist ◽  
Intestinal Occlusion ◽  
Surgical Emergencies

Gastrointestinal stromal tumours (GISTs) are rares connective tumors, usually located in the stomach or small intestine. Derived from Cajal cells or one of their precursors. Gastrointestinal stromal tumors (GISTs) represent 1% to 2% of all neoplasms of the digestive tract, The average age is between 50 and 60 years old, most often occurring in the stomach, Their clinical symptomatology is variable according to the region affected or the size of the lesion, they are responsibles for digestive bleeding, pain, or abdominal mass, as well as an alteration in the general state of health. More rarely, the diagnosis is made on the occasion of an intestinal occlusion. the  GIST complicated by occlusion due either to invagination of the tumour mass or to exophytic development of the tumour. In CT scans, they are manifested by a localised parietal tumour thickening of variable size with most often an exophytic development. Molecular biology plays an important role in this disease. The main treatment is radical surgery .The Imatinib has radically changed the prognosis of patients with unresectable and/or metastatic GIST. We report the case of a patient with a stromal tumour complicated by occlusion operated in emergency in the department of visceral surgical emergencies of Ibn Rochd UHC.

scholarly journals Gastrointestinal Stromal Tumours: Consensus Statement on Diagnosis and Treatment

2006 ◽  
Vol 20 (3) ◽  
pp. 157-163 ◽  
Author(s):  
Martin E Blackstein ◽  
Jean-Yves Blay ◽  
Christopher Corless ◽  
David K Driman ◽  
Robert Riddell ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumours ◽  
Organ Function ◽  
Committee Meeting ◽  
First Line ◽  
Computed Tomography Imaging ◽  
Secondary Resistance ◽  
Metastatic Gist ◽  
Genotypic Characteristics ◽  
Therapy Treatment

In the multidisciplinary management of gastrointestinal stromal tumours (GISTs), there is a need to coordinate the efforts of pathology, radiology, surgery and oncology. Surgery is the mainstay for resectable nonmetastatic GISTs, but virtually all GISTs are associated with a risk of metastasis. Imatinib 400 mg/day with or without surgery is the recommended first-line treatment for recurrent or metastatic GIST; a higher dose may be considered in patients who progress, develop secondary resistance or present with specific genotypic characteristics. Adjuvant or neoadjuvant imatinib is not advised for resectable non-metastatic GISTs. Neoadjuvant imatinib may be considered when surgery would result in significant morbidity or loss of organ function. Follow-up computed tomography imaging is recommended every three to six months for at least five years. Patients with metastatic disease should be continued on imatinib due to the high risk of recurrence on discontinuation of therapy. Treatment should be continued until there is progression or intolerable adverse effects. If dose escalation with imatinib fails, a clinical trial with novel agents alone or in combination may be considered. The present recommendations were developed at a surgical subcommittee meeting and a subsequent full Advisory Committee meeting held in Toronto, Ontario, in April 2005, under the sponsorship of Novartis Pharmaceuticals Canada Inc.

Efficacy of surgical treatment of patients with localized gastrointestinal stromal tumors

2016 ◽  
Vol 21 (5) ◽  
pp. 233-237
Author(s):  
Petr P. Arkhiri ◽  
I. S Stilidi ◽  
I. V Poddubnaya ◽  
S. N Nered ◽  
M. P Nikulin ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Cellular Structure ◽  
Kinase Inhibitors ◽  
Radical Surgery ◽  
Locally Advanced ◽  
Tumor Location ◽  
Main Method ◽  
Mutation Status ◽  
Stromal Tumors ◽  
Risk Of Disease

The main method of the treatment of patients with localized and locally advanced gastrointestinal stromal tumors (GIST) currently remains to be surgical, but its effectiveness is limited and determined by the degree of local expansion of the disease and radicality of the surgery. Before the era of the use of tyrosine kinase inhibitors (TKI) in the treatment of GIST patients the overall 5-year survival after radical surgery in the group of patients with size of the tumor larger than 10 cm failed to exceed 20%. For the time present with the comprehensive approach to the treatment indices of survival in these patients have significantly improved. Overall 5-year survival in patients with a high risk of disease progression reaches 93%. The most important prognostic factors in patients with primary localized GIST are: the size of the primary tumor, mitotic index, tumor location, mutation status and the morphological variant of the cellular structure of GIST.

scholarly journals Ovarian dysgerminoma: a case report

2021 ◽  
Vol 10 (4) ◽  
pp. 1704
Author(s):  
Shamrao Ramji Wakode ◽  
Varsha Narayana Bhat
Keyword(s):  
Young Women ◽  
Ovarian Neoplasms ◽  
Abdominal Mass ◽  
Total Abdominal Hysterectomy ◽  
Malignant Tumour ◽  
Abdominal Hysterectomy ◽  
Tumour Mass ◽  
Mesenteric Lymph ◽  
Beta Hcg ◽  
Ovarian Dysgerminoma

An ovarian dysgerminoma is a rare, malignant tumour occurring in young women, accounting for 1% to 2% of all primary ovarian neoplasms. A 22 years old female presented with 6 months of amenorrhea and lump in the abdomen. Her physical examination was remarkable with 36 weeks sized huge abdominal mass. Subsequent computed tomography revealed 22×23×32.4 cm mixed density lesion in pelvi-abdominal region and multiple paraaortic and mesenteric lymph node with gross pleural effusion. On further evaluation raised beta-hcG and LDH were noted and hence dysgerminoma was suspected. Total abdominal hysterectomy with right salpingo-ophorectomy with resection of tumour mass with partial omentectomy and lymphadenectomy was performed. Histopathology reports were suggestive of dysgerminoma. 

Extraordinarily Large Malignant Extra Gastro Intestinal Stromal Tumor Presenting as an Abdominal Mass

2019 ◽  
Vol 2 (2) ◽  
pp. 84-87
Author(s):  
P Paudyal ◽  
TN Subba ◽  
A Pradhan ◽  
S Dhakal ◽  
S Karki ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Histopathological Examination ◽  
Abdominal Mass ◽  
Correct Diagnosis ◽  
Standard Technique ◽  
Gastrointestinal Neoplasms ◽  
Epithelial Tumor ◽  
Stromal Tumors ◽  
Cut Surface ◽  
Histology And Immunohistochemistry

Background: Gastrointestinal stromal tumors (GIST) are rare of all gastrointestinal neoplasms with histology and immunohistochemistry similar to gastrointestinal stromal tumors. They occur outside the gastrointestinal tract rarely and are, hence, called the extra gastrointestinal stromal tumors (EGIST). Herein, we report a rare case of malignant extra intestinal gastrointestinal tumor. Case report: A 39 yr old female presented to the surgical OPD with a lump in the abdomen since 4 months. We received a lobulated tumor which measured 40x25x20 cm3 and showed capsule. Cut surface was predominantly solid, grey white with areas of hemorrhage and necrosis along with cystic areas. Histopathology and immunohisto chemistry revealed it to be a malignant EGIST of mesentery because of no continuity of the tumor with the small intestine microscopically. Conclusion: EGIST is a rare no epithelial tumor of mesentery. Omentum histopathological examination is a standard technique to diagnose the tumor and to differentiate it immunohistochemically from other tumors having similar morphology. Correct diagnosis plays valuable role in the treatment.

Gastrointestinal Stromal Tumors: Actin Expression, a New Prognostic Factor?

2010 ◽  
Vol 76 (11) ◽  
pp. 1244-1250 ◽  
Author(s):  
Jaime Ruiz-Tovar ◽  
María Diez-Tabernilla ◽  
Gada Housari ◽  
Enrique Martinez-Molina ◽  
Alfonso Sanjuanbenito
Keyword(s):  
Prognostic Factors ◽  
Small Bowel ◽  
Gastrointestinal Stromal Tumors ◽  
Abdominal Mass ◽  
Disease Free Survival ◽  
Gastric Gist ◽  
Free Survival ◽  
Stromal Tumors ◽  
Actin Expression ◽  
Disease Free

The aim of this study is to analyze the clinical outcome of gastrointestinal stromal tumors (GISTs) and to determine new prognostic factors. We perform a retrospective study of all the patients diagnosed with GIST in any location and operated on between 2000 and 2008 at our institution. We analyzed 35 patients, 16 males (45.7%) and 19 females (54.3%), with a mean age of 64 ± 13.8 years. The tumors were located in the stomach in 22 patients (62.9%), in the small bowel in 10 (28.6%), and the retroperitoneum in three (8.6%). Referring to gastric GIST, endoscopy revealed an ulceration in the mucosa in five cases, suggesting an epithelial neoplasm. In all these cases, pathology of the biopsy specimen was nonconclusive. Survival rate at 1 and 5 years was 94.3 and 88.6 per cent, respectively. Disease-free survival at 1 and 2 years was 91.4 and 88.6 per cent, respectively. Analyzing prognostic factors, a lower disease-free survival was observed among patients with constitutional syndrome at diagnosis ( P = 0.000), small bowel GIST ( P = 0.037), and tumors not expressing actin ( P = 0.015). A lower global survival was observed among men ( P = 0,036), patients with an abdominal mass ( P = 0.033) or with constitutional syndrome ( P = 0.007) at diagnosis and tumors at a retroperitoneal location ( P = 0.0002). Gastric GIST may be confused with epithelial neoplasms, modifying the surgery. In our patients, masculine gender, constitutional syndrome and abdominal mass at diagnosis, small bowel and retroperitoneal location, and actin negative tumors are bad prognostic factors.

scholarly journals Huge Sertoli-Leydig cell tumor: a rare case report

2019 ◽  
Vol 9 (1) ◽  
pp. 432
Author(s):  
Mridula Raghav ◽  
Ashok R. Anand
Keyword(s):  
Leydig Cell ◽  
Frozen Section ◽  
Abdominal Mass ◽  
Total Abdominal Hysterectomy ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Ca 125 ◽  
Free Fluid ◽  
Tumour Mass ◽  
Umbilical Hernia Repair

Sertoli-Leydig cell tumors (SLCTs), constitute less than 0.5% of all ovarian tumors. SLCT are rare after menopause (less than10%), 75 years, unmarried, postmenopausal since 30 years, presented with complaints of abdominal swelling. On examination, abdominal mass of 36 weeks, hard, immobile felt. Ultrasonography of abdomen showed lobulated solid cystic lesion of size 22 x 15 x 27 cms with bilateral ovaries not separately visualized. Moderate free fluid in the abdomen, suggestive of malignant neoplastic etiology. CECT Abdomen + pelvis suggestive of primary ovarian malignancy with omental deposits and pelvic adenopathy. CA 125- 415.1 Patient underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy with huge tumour mass excision (weight 5.25 kg) with umbilical hernia repair. Frozen section suggestive of a huge mass of 30 x 20 x 15 cm, multilobulated, yellowish white tan in colour, solid-cystic in consistency, seen arising from right ovary. Omentum appears normal. Histopathology report s/o- Moderately differentiated Sertoli Leydig cell tumor. Reporting the first, this huge, in this age group with atypical presentation.

Giant Retroperitoneal Dedifferentiated Liposarcoma: A Case Report

2020 ◽  
Vol 13 (1) ◽  
pp. 67-70
Author(s):  
Dobromir D. Dimitrov
Keyword(s):  
Radical Surgery ◽  
Abdominal Mass ◽  
Soft Tissue Sarcomas ◽  
Surgical Oncology ◽  
Incidence Rates ◽  
Complete Resection ◽  
University Hospital ◽  
Dedifferentiated Liposarcoma ◽  
Rare Entity ◽  
The University

Summary Retroperitoneal soft tissue sarcomas comprise a relatively rare entity with incidence rates of less than 1% of all malignancies. The surgical treatment of these tumors is challenging. We present a case of a 70-year-old patient who underwent radical surgery at the Department of Surgical Oncology at the University Hospital in Pleven for giant dedifferentiated liposarcoma. The patient presented with cachexia, anemia, dull abdominal pain, and a huge abdominal mass. After ultrasound and CT, the tumor was assessed as resectable. The removed tumor mass weighed 5.7 kg. Nowadays, complete resection of such tumors remains the most important predictive factor for local recurrence and overall survival.

EXPECT THE UNEXPECTED: JEJUNAL GASTROINTESTINAL TUMOUR MIMICKING OVARIAN MALIGNANCY- A CASE REPORT WITH REVIEW OF LITERATURE

2021 ◽  
pp. 12-13
Author(s):  
Shivangi Singh ◽  
Munesh Munesh ◽  
Sweta Sweta
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Alimentary Tract ◽  
Ovarian Malignancy ◽  
Review Of Literature ◽  
Gastrointestinal Stromal Tumours ◽  
Stromal Tumors ◽  
Epitheloid Cells ◽  
Missed Diagnosis ◽  
Small Intestinal ◽  
Mesenchymal Tumours

Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours of alimentary tract comprising 0.2% of gastrointestinal tumors and only 0.04% of small intestinal tumours. Jejunal GISTs are one of the rarest subtypes. GISTs display various morphological forms like spindle and epitheloid cells in a variety of patterns and can be submucosal, intramuscular or subserosal in location. Grossly they are solid and cyst with variable hemorrhage and necrosis. Most of the gastrointestinal stromal tumors have mutations in either KIT (CD117) or PDGFRα gene. DOG 1 is a sensitive and specic marker of GIST independent of CD117 or PGDFRα expression. Here we present a case of malignant jejunal GIST with missed diagnosis on CECT abdomen.

scholarly journals Primary intestinal fibrosarcoma caused by intestinal perforation in a dog: a case report

2012 ◽  
Vol 57 (No. 6) ◽  
pp. 314-319 ◽  
Author(s):  
H. Avci ◽  
R. Yaygingul ◽  
M. Gultekin ◽  
ET Epikmen ◽  
K. Ural ◽  
...  
Keyword(s):  
Intestinal Perforation ◽  
Present Report ◽  
Abdominal Mass ◽  
Neuron Specific Enolase ◽  
Intestinal Wall ◽  
Tumour Mass ◽  
Neoplastic Cells ◽  
S 100 ◽  
History Of ◽  
Gross Examination

An 11-year-old male Cocker Spaniel was examined for a palpable abdominal mass located in the jejunum after presenting with a history of anorexia and constipation for several weeks. In a contrast radiogram, a structure with well-defined borders adjacent to the intestine was determined. The intestinal mass, measuring 16 × 9.19 × 8.6 cm and weighing 900 g was surgically removed. At gross examination, when the lumen of a portion of the intestine excised together with the tumour mass was exposed, an ulcerated, oval-shaped area 1.2 × 0.6 cm in size was observed on the mucosa. The outer surface of the tumour was homogenous and expanded outwards from the intestinal wall. Histologically, the tumour was composed of fusiform-elongated spindle-shaped to polygonal neoplastic cells forming interlacing fascicles or interwoven bundles in an atypical herringbone pattern. Immnunohistochemically, neoplastic cells stained intensely positive for vimentin, and negative for α-SMA, desmin, cyotokeratin (AE1/AE3), S-100 protein, glial fibrillary acidic protein, neuron specific enolase and synaptophsin. On the basis of the histopathological and immunohistochemical results, the tumour was diagnosed as a fibrosarcoma. The present report is a very rare description of fibrosarcoma of the dog intestine associated with intestinal perforation.  

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