scholarly journals Association of Neutrophil to Lymphocyte Ratio with Clinicopathological Features in Breast Cancer

2021 ◽  
pp. 93-100
Author(s):  
Rufina Soomro ◽  
Namiya Cho
Keyword(s):  
Breast Cancer ◽  
Complete Blood Count ◽  
Cross Sectional Study ◽  
Neutrophil To Lymphocyte Ratio ◽  
Cross Sectional ◽  
Lymphocyte Ratio ◽  
Medical College ◽  
Breast Malignancy ◽  
Peripheral Blood Neutrophil ◽  
Inflammatory Conditions

Background: Even with the advances in the diagnosis and treatment of breast malignancy, to date breast cancer is still the number one cause of death in women in Pakistan. Various researches proved that prolonged inflammatory conditions played a part in progression of malignancy, these factors also promote growth leading to poor prognosis. This study shows the analysis of peripheral blood neutrophil to lymphocyte ratio (NLR) in breast malignancy and its association with disease characteristics Methods: The cross-sectional study was done in Liaquat National Hospital and Medical College, Karachi. Pakistan.  A total of 2059 female patient population with breast cancer hit the criteria. The patients were asked to undergo a complete blood count with leukocyte differential preoperatively. Patients’ complete data was collected preoperatively including specimen-related histopathology reports. Patients excluded were those with clinical evidence of ongoing active infection/sepsis, any blood disorders, any previous or ongoing inflammatory or autoimmune diseases, and steroid therapy. Results: No association was seen between the NLR with the age, grade, and luminal subtypes. However, NLR had a significant association with the size and stage of the disease. With an increase in NLR, the stage increased. Conclusion: The study identifies the usefulness of the NLR ratio, which in the future can be used as a diagnostic adjunct in the preoperative workup of patients with breast malignancy.

scholarly journals NEUTROPHIL TO LYMPHOCYTE RATIO, A NOVEL BEDSIDE PREDICTOR OF ENDOSCOPIC DAMAGE IN CORROSIVE GI INJURIES

2020 ◽  
pp. 1-3
Author(s):  
Noble Varghese Mathews ◽  
K. Premkumar ◽  
Murali Ramamoorthy ◽  
A. Chezhian ◽  
A. R. Venkateswaran ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Neutrophil To Lymphocyte Ratio ◽  
Caustic Ingestion ◽  
Severe Injuries ◽  
Cross Sectional ◽  
Lymphocyte Ratio ◽  
Medical College ◽  
Comparison Groups ◽  
History Of ◽  
Madras Medical College

AIM- To determine an association between neutrophil to lymphocyte ratio (NLR) and severity of endoscopic injury. MATERIALS AND METHODS- A cross-sectional study of 153 adult patients admitted to Madras medical college, following history of caustic ingestion during a 6-month period. The association between NLR within 24 hours of ingestion and endoscopic injury based on Zargar classification was studied. The association between NLR and endoscopic findings were studied. RESULTS AND DISCUSSION- Of the 153 patients studied, 117 had mucosal injuries and 36 normal. 54 of the 117 patients had multi-regional injury and 63 had single regional injuries. Of which, by Zargar classification, Grade I- 57, Grade II- 35 and Grade III-25 patients. Mean NLR of the sample was 3.4. AUC > 80% was noted for NLR cut-offs across all comparison groups namely, High vs lower grades (NLR≥4.32, AUC:0.978, 95% CI 0.95-1.0, p<0.001), a similar Turkish study by Uyar et al had a cut off of 8.7, however the sample size was smaller with only ten patients having poorer graded injuries. The NLR cut-offs of Injured vs non-injured (NLR≥1.49, AUC:0.845, 95% CI 0.78-0.91, p<0.001) and Single vs multi-regional injuries (NLR≥2.27, AUC:0.86, 95% CI 0.80-0.93, p<0.001), were comparable to the previous study. CONCLUSION- Higher NLR values predicted severe and multi-regional injuries. It helped to distinguish between mild and severe injuries, thereby serving as an inexpensive, non-invasive and bedside tool to predict and grade corrosive injuries for patients awaiting or inaccessible to immediate endoscopic evaluation and plan further care.

scholarly journals A Cross-Sectional Study of Neutrophil-to-Lymphocyte Ratio in Diagnosing Acute Appendicitis in Hospital Melaka

2019 ◽  
Vol 26 (6) ◽  
pp. 55-66
Author(s):  
Khairol Ashraf Ahmad ◽  
◽  
Noorharisman Ideris ◽  
Syed Hassan Syed Abd Aziz ◽  
◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Cross Sectional Study ◽  
Neutrophil To Lymphocyte Ratio ◽  
Sectional Study ◽  
Cross Sectional ◽  
Lymphocyte Ratio

scholarly journals Associations between the Neutrophil-to-Lymphocyte Ratio and Diabetic Complications in Adults with Diabetes: A Cross-Sectional Study

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Heng Wan ◽  
Yuying Wang ◽  
Sijie Fang ◽  
Yi Chen ◽  
Wen Zhang ◽  
...  
Keyword(s):  
Diabetic Complications ◽  
Large Population ◽  
Cross Sectional Study ◽  
Cerebrovascular Diseases ◽  
Neutrophil To Lymphocyte Ratio ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Lymphocyte Ratio ◽  
Urine Albumin ◽  
Laboratory Index

Objective. The neutrophil-to-lymphocyte ratio (NLR) is an inexpensive and easily measurable laboratory index indicating systemic inflammation, while the application of many other inflammatory markers has been limited in daily clinical practice. However, large population studies about investigating the associations of the NLR level with diabetic complications including cardiovascular and cerebrovascular diseases (CVD), diabetic kidney disease (DKD), and diabetic retinopathy (DR) in the same population were limited. The aim of our study is to evaluate the associations between the NLR level and the prevalence of CVD, DKD, and DR in adults with diabetes simultaneously. Methods. A cross-sectional survey of 4,813 diabetic adults was conducted in seven communities in China. Persons underwent several medical examinations, including the measurement of anthropometric factors, blood pressure, routinely analyzed leukocyte characteristics, glucose, lipid profiles, urine albumin/creatinine ratio, and fundus photographs. Results. Compared with the first quartile of the NLR level, the odds of having CVD was significantly increased by 21% for participants in the highest quartile (OR 1.21; 95% CI 1.00, 1.47) (P for trend<0.05). Similarly, the prevalence of DKD among participants in the highest quartile of the NLR level was significantly increased by 150% (OR 2.50; 95% CI 1.95, 3.19) (P for trend<0.05). However, no association was found between the NLR level and the prevalence of DR (P for trend>0.05). These associations were all fully adjusted. Conclusions. A higher NLR level was associated with an increased prevalence of CVD and DKD, other than DR, in diabetic adults.

CYSTATIN–C AS AN EARLY INDICATOR FOR INCIPIENT RENAL DISEASE IN RHEUMATOID ARTHRITIS-A HOSPITAL BASED CROSS SECTIONAL STUDY

2021 ◽  
Vol 5 (8) ◽  
Author(s):  
Kishor Singh Choudhary ◽  
Arvind Kumar Jain ◽  
Ashok Kumar Kachhawaha ◽  
Narendra Choudhary
Keyword(s):  
Renal Disease ◽  
Cystatin C ◽  
Complete Blood Count ◽  
Cross Sectional Study ◽  
Serum Cystatin C ◽  
Kidney Size ◽  
Cross Sectional ◽  
Medical College ◽  
Function Test ◽  
Diagnostic Capacity

Background: The aim of the present study was to examine the diagnostic capacity of this new parameter towards early signs of renal disease in patients suffering from prolonged RA requiring potential nephrotoxic therapy. Methods: The present study was a cross sectional observational type of study conducted in the department of medicine Mathura Das Mathur Hospital,    Dr. S.N. Medical College, Jodhpur. A total of 50 subjects that fulfilled the inclusion and exclusion criteria were enrolled in the study after informed and written consent. As per methodology complete blood count, ESR, liver function test, kidney function test, cystatin-c, urine complete, 24 hours urine creatinine, USG abdomen for kidney size were performed. Results: cystatin–C level below 0.95 mg/dl was considered normal. 19 patients have normal and 31 patients have abnormal more than 0.95 mg/dl. Conclusion: In conclusion, as compared to serum creatinine, the determination of serum cystatin C is comparably simple, but by far more sensitive for the diagnosis of incipient renal damage in RA, and therefore valuable for clinical screening particularly in cases with prolonged antirheumatic treatment. Keywords: Cystatin C, RA, KFT

scholarly journals Neutrophil-to-lymphocyte ratio exhibits the different correlation with psychiatric symptoms in the different status of antipsychotic therapy in schizophrenia: a large-scale retrospective cross-sectional study.

2020 ◽  
Author(s):  
Hong Shen ◽  
Xia Zhou ◽  
Xiaolan Wang ◽  
Rui Li ◽  
Ying Xiao ◽  
...  
Keyword(s):  
Disease Severity ◽  
Psychiatric Symptoms ◽  
Cross Sectional Study ◽  
Small Sample ◽  
Neutrophil To Lymphocyte Ratio ◽  
Confounding Factors ◽  
Sectional Study ◽  
Antipsychotic Therapy ◽  
Cross Sectional ◽  
Lymphocyte Ratio

Abstract Background There are some conflicting results regarding the neutrophil-to-lymphocyte ratio (NLR) and the severity of disease in patients with schizophrenia. Inconsistent findings among the studies might be caused by several limitations, such as, heterogeneous patient populations lacking stratification by antipsychotic therapy, small sample sizes lacking statistical power, ignoring multicollinearity between NLR and other related factors, and lack of controlling for potential confounding factors. In this study, we evaluated the possible correlation between NLR and disease severity as manifested in clinical scores in patients with schizophrenia. In particular, NLR is correlated with discrepant psychiatric symptoms in the different status of antipsychotic medication administration. Methods This was a cross-sectional study conducted in our hospital. We identified inpatients with schizophrenia between July 12, 2018 and March 27, 2019 and who had NLR, Clinical Global Impression Severity scale (CGIS) and Brief Psychiatric Rating Scale (BPRS) scores. Results The records of 1144 identified patients (32.4% male, 76.6% with NLR ≤ 1.98, and 10.8% drug-free patients) were analyzed. Multivariate logistic regression showed that NLR was positively associated with worse psychiatric symptoms, both the CGIS score (moderately ill: OR: 63.578, p = 0.011; severely ill: OR: 53.617, p = 0.015) and the BPRS total score (moderately ill: OR: 4.049, p = 0.055; severely ill: OR: 4.312, p = 0.045). In the drug-therapy subgroup, there was a negative correlation between NLR and severe negative symptoms (severely ill: OR: 0.850, p = 0.018) after controlling for potential confounding factors. Conclusions The study is the first to confirm the hypothesis that NLR is independently associated with severe psychopathology in schizophrenia. There is the different correlation between NLR and psychiatric symptoms in the different status of antipsychotic therapy. Therefore, NLR is not appropriate to be an inflammatory biomarker for assessment of disease severity, but provide potential mechanistic insights on specific pathological cellular processes, as well be a potential target to improve the course of the psychotic disorder.

scholarly journals Severity-dependent variations of the neutrophil to lymphocyte ratio (NLR) in peripheral vestibular vertigo

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Andi Kurnia Bintang ◽  
Eva Iin Magasingan
Keyword(s):  
Inflammatory Marker ◽  
Cost Effective ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Neutrophil To Lymphocyte Ratio ◽  
University Teaching ◽  
Cross Sectional ◽  
Lymphocyte Ratio ◽  
Significant Difference ◽  
Vestibular Vertigo

Abstract Background Peripheral vestibular vertigo is a common cause of vertigo especially in the elderly. The neutrophil to lymphocyte ratio (NLR) is a rapid and cost-effective inflammatory marker that has been assessed previously in peripheral vestibular disorders. However, its relation to the severity of peripheral vertigo has not been previously investigated. The aim of this study is to assess the levels of NLR in peripheral vestibular vertigo of various severity categories. This was a cross-sectional study at the Wahidin Sudirohusodo Hospital and Hasanuddin University Teaching Hospital in Makassar. The NLR was measured among subjects with periphel vestibular vertigo with severity categorised using the Dizziness Handicap Inventory (DHI) questionnaire. Results A total of 39 participants with peripheral vestibular vertigo were recruited. A statistically significant difference was found (p = 0.002, Kruskal–Wallis ANOVA) between the mean NLR for the mild, moderate, and severe DHI categories were 2.47 ± 1.66, 2.64 ± 0.96, and 5.15 ± 2.59 respectively. Conclusion A significant difference in the NLR was found between the three different vertigo severity groups, wherein NLR values rise with increase in vertigo severity. This warrants further exploration on the role of inflammatory biomarkers in vertigo pathophysiology and clinical assessment.

scholarly journals SPECTRUM OF PANCYTOPENIA

2016 ◽  
Vol 23 (05) ◽  
pp. 620-626
Author(s):  
Tariq Hameed Rehmani Rehmani ◽  
Mizna Arif ◽  
Sajjad Heraid ◽  
Sarah Arif ◽  
Rabia Ahmad ◽  
...  
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Megaloblastic Anemia ◽  
Clinical History ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Male Predominance ◽  
Medical College ◽  
Study Setting

Pancytopenia refers to a reduction in all the three cellular elements of blood.Pancytopenia is a common but important hematological problem encountered in routineclinical Practice. It may be a presenting feature of many underlying serious and life threateningillnesses. Objective: Present study was planned to appraise various clinico- etiologicalfactors underlining Pancytopenia. Study Design: Cross-sectional study. Setting: HematologyDepartment of Allama Iqbal Medical College/ Jinnah Hospital Lahore (AIMC&JHL). Period:July 2011 to Jun 2015. Materials and Methods: Two hundred and forty four patients withPancytopenia were included in the study. Complete blood count, bone marrow aspirations andtrephine biopsies were performed after clinical history and physical exam. Data were analyzedby using SPSS 20.0 version. Results: Out of total 244 Pancytopenia cases, hypoplastic bonemarrow 66 (27.04%) and Megaloblastic anemia 49 (20.08%) were the most common etiologicalfactors with male predominance. Fever and pallor were striking presenting clinical features.Conclusion: We conclude that Pancytopenia is a common problem with an exhaustive listof differential diagnosis, some of which are easily treatable and reversible. Therefore earlydetection with optimal diagnostic approach to Pancytopenia is required for better managementof patients.

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