scholarly journals Acute Polyarticular Gout due to Chronic Kidney Disease

2021 ◽  
pp. 666-669
Author(s):  
K. Arvind Natarajan ◽  
P. Saravanan
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Uric Acid ◽  
Pain Relief ◽  
Bone Destruction ◽  
Great Toe ◽  
Crystal Deposition ◽  
Fluid Analysis ◽  
Progression Of Disease ◽  
Renal Function Tests

Gout is a crystal deposition disorder that typically presents as an acute flare of the first metatarso-phalangeal joint of the great toe. Rarely gout can present as an acute poly-articular disease with involvement of multiple joints. Evaluation of patients with poly-articular arthropathy with appropriate investigations like uric acid levels, renal function tests and synovial fluid analysis helps in the early diagnosis of poly-articular gout. Immediate treatment with urate lowering agents during the acute flare provides immediate pain relief and prevents progression of disease & bone destruction.

scholarly journals The Correlation Between Lipid Profile and Renal Function Tests in Patients with Cardiovascular Disease

2020 ◽  
pp. 51-59
Author(s):  
Hardi Rafat Baqi ◽  
Shkar Rzgar K. Rostam
Keyword(s):  
Cardiovascular Disease ◽  
Renal Function ◽  
Uric Acid ◽  
Regression Analysis ◽  
Statistical Analysis ◽  
Linear Regression ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Renal Function Tests ◽  
Statistical Analysis Methods

Cardiovascular disease patients frequently suffer from the incidence of renal dysfunctions, the prevalence of the correlation, however, remains ambiguous. This study aims to see how CVD and renal function are related to the subjected group of patients suffer from symptoms of CVD. The method recruited for this objective was using of serum lipid profile test as a marker for evaluating the CVD and making correlations to the blood urea, serum uric acid, and serum creatinine levels as markers for assessing renal function on 159 individuals with CVD symptoms in Erbil city. Two statistical analysis methods (The linear regression and Pearson’s correlation) were employed for determining the existence from a lack of relationship between them. The results showed a statistically significant correlation p<0.05 by both methods between the renal function markers and TC. The UA was correlated to TG, LDL-C, and VLDL-C p<0.05 by regression analysis. The SCr was correlated to TG and LDL-C p<0.05 by both methods, and to VLDL by regression analysis. According to the outcome of the current study both lipid profile and renal function markers are correlated in mostly a statistically significant manner. Yet, the results are not conclusive, further studies are needed in this area for indemnify the irrefutable evidence concerning this relation.

scholarly journals Cystatin C is a Better Marker of Renal Dysfunction in Hypertensive Pregnancies

2016 ◽  
Vol 20 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Rajeev Ranjan ◽  
Anjana Singh
Keyword(s):  
Renal Function ◽  
Uric Acid ◽  
Serum Creatinine ◽  
Renal Dysfunction ◽  
Cystatin C ◽  
Normal Pregnancy ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Function Tests ◽  
Renal Function Tests

ABSTRACT Background Glomerular endotheliosis is an essential component in the pathophysiology of gestational hypertension (GH) and preeclampsia (PE) which results in renal dysfunction. This is not always detected by routine renal function tests, such as serum creatinine, urea, and uric acid. Cystatin C, an endogenous cysteine protease inhibitor, is completely absorbed by renal tubules and has been shown to be an ideal marker of glomerular filtration rate (GFR), which needs to be evaluated in assessing renal dysfunction occurring in GH and PE. Aims The present study is designed to evaluate serum cystatin C levels in normal pregnancy, GH, and PE and compare its efficacy with traditional renal function tests. Materials and methods In this prospective cross-sectional study, 75 subjects enrolled, comprised of 25 subjects each of normal pregnancy, GH, and PE. Serum cystatin C, blood urea, serum creatinine, serum uric acid, and urinary protein/creatinine ratio were estimated in all subjects prior to delivery. Results All renal parameters including cystatin C were significantly raised in GH and PE compared with control group. However, only serum cystatin C level (and no other renal parameters) was significantly higher in PE group compared with GH group. Area under the curve for cystatin C was maximum (0.917) compared with other parameters. Cystatin C had a higher sensitivity and specificity than other conventional markers. Conclusion Serum cystatin C is a better marker of renal dysfunction in hypertensive pregnancies. How to cite this article Singh A, Gupta M, Ranjan R, Saini V, Gupta SK. Cystatin C is a Better Marker of Renal Dysfunction in Hypertensive Pregnancies. Indian J Med Biochem 2016; 20(1):21-27.

scholarly journals A REVIEW ON THE EFFECT OF FEBUXOSTAT IN CHRONIC KIDNEY PATIENTS, IT’S SIGNIFICANCE IN eGFR, URIC ACID AND ALBUMINURIA.

2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Jinsu Deena Jose ◽  
Mathew George ◽  
Lincy Joseph
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Uric Acid ◽  
Kidney Disease ◽  
Uric Acid Level ◽  
Acid Level ◽  
Oxidase Inhibitor ◽  
Xanthine Oxidase Inhibitor ◽  
Irreversible Reduction ◽  
Risk Of Progression

Chronic kidney disease is defined as the abnormality of the kidney structure or function for≥ 3 months and is associated with an irreversible reduction of the excretory and the endocrine functions of the kidney. An important risk factor for the development and progression of CKD is hyperuricemia. Hyperuricemia can occur as a result of the increased production or the reduced secretion of uric acid. Increased uric acid level is significantly associated with a greater decline in renal function and there is a higher risk of progression into kidney failure. Febuxostat is a nonpurine xanthine oxidase inhibitor for the treatment of hyperuricemia in patients with chronic kidney disease. It reduces serum uric acid concentrations by blocking the transformation of hypoxanthine to xanthine and xanthine to uric acid. Febuxostat is mainly metabolized in the liver and excreted through both urine and feces. Renal adjustment is also not required in CKD patients with mild to moderately reduced eGFR as it is metabolized mainly by glucuronidation and oxidation in the liver and well excreted by both urinary and fecal routes. Recent studies show that, in addition to lowering the uric acid level, febuxostat preserves the eGFR. Keywords:  Chronic kidney disease, hyperuricemia, febuxostat, eGFR

Uric Acid may predict post cardiac surgery renal function in patients with or without chronic kidney disease

2020 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Alsayed Alnahal ◽  
Mohamed Alanwer ◽  
Sameh Soliman ◽  
Mohamed Allam ◽  
Amir Abdelsayed
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Uric Acid ◽  
Cardiac Surgery ◽  
Kidney Disease ◽  
Post Cardiac Surgery

Effect of elevated serum uric acid on cisplatin-induced acute renal failure

2007 ◽  
Vol 292 (1) ◽  
pp. F116-F122 ◽  
Author(s):  
Carlos A. Roncal ◽  
Wei Mu ◽  
Byron Croker ◽  
Sirirat Reungjui ◽  
Xiaosen Ouyang ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Uric Acid ◽  
Renal Injury ◽  
Elevated Serum ◽  
Urate Oxidase ◽  
Crystal Formation ◽  
Tubular Injury ◽  
Crystal Deposition

Marked hyperuricemia is known to cause acute renal failure via intrarenal crystal deposition. However, recent studies suggest mild hyperuricemia may have vasoactive and proinflammatory effects independent of crystal formation. We therefore tested the hypothesis that mild hyperuricemia might exacerbate renal injury and dysfunction in a model of cisplatin-induced acute renal failure in the rat. Cisplatin was administered to normouricemic and hyperuricemic rats (the latter generated by administering the urate oxidase inhibitor, oxonic acid). Recombinant urate oxidase (rasburicase) was administered in a third group to assess the effect of lowering uric acid on outcomes. Other control groups include normal rats and hyperuricemic rats without cisplatin-induced injury. Cisplatin induced injury of the pars recta (S3) segment of the proximal tubule in association with a mild monocyte infiltration. Hyperuricemic rats showed significantly greater tubular injury and proliferation with significantly greater macrophage infiltration and increased expression of monocyte chemoattractant protein-1. However, renal function was not different between normouricemic and hyperuricemic rats with cisplatin injury. Treatment with rasburicase reversed the inflammatory changes and lessened tubular injury with an improvement in renal function (relative to the hyperuricemic group). No intrarenal crystals were observed in any groups. These data provide the first experimental evidence that uric acid, at concentrations that do not cause intrarenal crystal formation, may exacerbate renal injury in a model of acute renal failure. The mechanism may relate to a proinflammatory pathway involving chemokine expression with leukocyte infiltration.

scholarly journals A Retrospective Study on Sex Difference in Patients With Urolithiasis: Who Is More Vulnerable to Chronic Kidney Disease?

2021 ◽  
Author(s):  
Ching-Chia Li ◽  
Tsu-Ming Chien ◽  
Yen-Man Lu ◽  
Yii-Her Chou
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Uric Acid ◽  
Kidney Disease ◽  
Sex Difference ◽  
Potential Risk ◽  
Stone Disease ◽  
Public Health Issue ◽  
Carbonate Apatite ◽  
Uric Acid Stone

Abstract Background: Urolithiasis is considered a vital public health issue with a substantial burden on kidney function. Additionally, only few reports focused on the gender difference in patients with urolithiasis. Therefore, this study aimed to compare the clinical characteristics of sex difference and their potential risk for chronic kidney disease (CKD) in patients with urolithiasis.Methods: Patients diagnosed with stone disease from 2013 to 2018 were retrospectively reviewed and divided into two groups by gender. Clinical demographic characteristics, stone location, stone composition, urine chemistries, and renal function were investigated. Univariate and multivariate analyses were used to assess the relationship and potential risk of CKD between sex groups.Results: A total of 1,802 stones were included: 1,312 from men and 490 from women. Female patients had higher rate of hypertension, diabetes, and dyslipidemia. Male patients predominantly had calcium-containing stones, especially calcium oxalate stone, uric acid stone, and struvite stone. Carbonate apatite stone was more frequently found in women. Complex surgeries such as percutaneous nephrolithotomy (PCNL) and ureteroscopic lithotripsy (URSL) were more frequently performed in women than that in men. Multivariate analysis confirmed that age >60 years (odds ratios [ORs] = 6.36; 95% confidence interval [CI], 3.8–10.8), female sex (ORs = 5.31; 95% CI 3.3–8.4), uric acid stone (ORs = 3.55; 95% CI 2.0–6.4), hypertension (OR = 7.20; 95% CI 3.8–13.7), and diabetes (OR = 7.06; 95% CI 3.1–16.2) were independent predictors of poor prognoses in CKD.Conclusions: Gender is significantly associated with higher prevalence of CKD among patients with urolithiasis. Therefore, women with stone disease may need close renal function monitoring during follow-up.

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