scholarly journals Identifying Possible Hepatic Fibrosis of Hepatitis B Origin Using Non-invasive Markers: A Case-control Study in the South West Region of Cameroon

2019 ◽  
pp. 1-12
Author(s):  
Kukwah Anthony Tufon ◽  
Henry Dilonga Meriki ◽  
Kwenti Emmanuel Tebit ◽  
Teuwafeu Denis Georges ◽  
Nyeke James Tony ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Hepatitis B ◽  
Hepatic Fibrosis ◽  
Case Control Study ◽  
Case Control ◽  
Non Invasive ◽  
West Region ◽  
South West ◽  
Control Study ◽  
South West Region

Aim: HBV infection is known to cause liver fibrosis as well as some extrahepatic manifestations. We aimed at assessing hematological changes and identifying possible hepatic fibrosis of Hepatitis B origin using non-invasive markers (NIMs). Study Design: A hospital-based Case-control study Place and Duration of Study: Conducted at the Buea Regional Hospital, South West Region of Cameroon from February 2016 to December 2017 Methods: We enrolled HBV infected treatment naïve patients and “healthy” controls. All participants were subjected to alanine aminotransferase (ALT) and aspartate aminotransferase (AST) measurement, Full blood count (FBC), HBsAg, anti-HBc, HIV and HCV tests. Aspartate-platelet ratio index (APRI), fibrosis based on 4 factors (FIB-4), age-platelet index (API) and AST/ALT ratio (AAR) were generated from the test results. A questionnaire was administered to collect demographic data, alcohol consumption and history of liver/kidney disease or metabolic syndrome. Results: A total of 202 cases and 202 controls were enrolled. Hematocrit (HCT) was significantly higher (p<0.001) in cases than controls. The controls had significantly higher mean values for platelet (p=0.005), neutrophil (p=0.032) and number of individuals with AST/ALT ratio (AAR) ≥1. Liver fibrosis was significantly associated with cases than controls based on APRI (OR:6.06, CI:3.59-10.24), FIB-4 (OR:5.35, CI:2.75-10.39) and API (OR:8.02, CI:1.81-35.55). Among the HBV infected cases, 69 (34.2%), 36(17.8%) and 8(4.0%) had results indicative of fibrosis from at least 2, at least 3 and all 4 NIMs respectively. AAR detected possible fibrosis in 136 HBV infected cases of which up to 77 (56.6%) were not detected as fibrosis by the other NIMs. Conclusion: HBV infection affects neutrophil percentage, HCT, PLT, APRI, FIB-4 and API in our study population. AAR did not prove to be a reliable NIM. Using at least 3 NIMs for HBV infected patients can significantly scale up their reliability for determining liver fibrosis in clinical practice.

scholarly journals Use of Non-Invasive Parameters of Non-Alcoholic Steatohepatitis and Liver Fibrosis in Daily Practice - An Exploratory Case-Control Study

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e111551 ◽  
Author(s):  
Karel Dvorak ◽  
Jan Stritesky ◽  
Jaromir Petrtyl ◽  
Libor Vitek ◽  
Renata Sroubkova ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Case Control Study ◽  
Daily Practice ◽  
Case Control ◽  
Non Invasive ◽  
Alcoholic Steatohepatitis ◽  
Control Study

scholarly journals Hepatitis B virus pre-S deletion mutations are a risk factor for hepatocellular carcinoma: a matched nested case–control study

2008 ◽  
Vol 89 (11) ◽  
pp. 2882-2890 ◽  
Author(s):  
Zhong-Liao Fang ◽  
Caroline A. Sabin ◽  
Bai-Qing Dong ◽  
Shao-Chao Wei ◽  
Qin-Yan Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Factor ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Case Control Study ◽  
Case Control ◽  
Deletion Mutations ◽  
B Virus ◽  
Nested Case Control ◽  
Control Study

A matched nested case–control study of 33 paired cases and controls was conducted, based on a study cohort in Long An county, Guangxi, China, to determine whether infection with hepatitis B virus (HBV) with pre-S deletions is independently associated with the development of hepatocellular carcinoma (HCC), without the confounding effects of basal core promoter (BCP) double mutations. The prevalence of pre-S deletions was significantly higher in HCC (45.5 %, 15 of 33) than the controls (18.2 %, 6 of 33) (P<0.01), under the control of the influence of BCP double mutations. Most of the pre-S deletions occurred in, or involved, the 5′ half of the pre-S2 region and the difference between HCC (93.3 %, 14 of 15) and controls (66.7 %, four of six) was significant for this region (P=0.015). There was no significant difference in pre-S deletions between the BCP mutant group and BCP wild-type group (P>0.05), nor was the prevalence of pre-S deletions significantly different between genotypes B and C (P>0.1). These results suggest that pre-S deletions constitute an independent risk factor for HCC and their emergence and effect are independent of BCP mutations. The 5′ terminus of pre-S2 is the favoured site for the deletion mutations, especially in HCC cases. Further prospective studies are required to confirm the role of these mutations in the development of HCC.

Inverse relationship between hepatic steatosis and hepatitis B viremia: Results of a large case-control study

2017 ◽  
Vol 25 (1) ◽  
pp. 97-104 ◽  
Author(s):  
R. W. H. Hui ◽  
W.-K. Seto ◽  
K.-S. Cheung ◽  
L.-Y. Mak ◽  
K. S. H. Liu ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Hepatic Steatosis ◽  
Inverse Relationship ◽  
Case Control Study ◽  
Case Control ◽  
Control Study ◽  
Large Case

Nutritional factors and pancreatic cancer: A case-control study from South-West Poland

1991 ◽  
Vol 48 (3) ◽  
pp. 390-394 ◽  
Author(s):  
W. Zatonski ◽  
K. Przewozniak ◽  
G. R. Howe ◽  
P. Maisonneuve ◽  
A. M. Walker ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Nutritional Factors ◽  
South West ◽  
Control Study

Acceptance of a new non-invasive fetal monitoring system and attitude for telemedicine approaches in obstetrics: a case–control study

2018 ◽  
Vol 298 (6) ◽  
pp. 1085-1093 ◽  
Author(s):  
Katharina Schramm ◽  
Florian Lapert ◽  
Juliane Nees ◽  
Carlijn Lempersz ◽  
S. Guid Oei ◽  
...  
Keyword(s):  
Monitoring System ◽  
Case Control Study ◽  
Fetal Monitoring ◽  
Case Control ◽  
Non Invasive ◽  
Control Study
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