scholarly journals International Journal of Pharmaceuticals Analysis

2013 ◽  

1981 ◽  
Vol 14 (13) ◽  
pp. 1013-1030 ◽  
Author(s):  
Jeri Roth ◽  
Rao S. Rapaka ◽  
Vadlamani K. Prasad


2010 ◽  
Vol 64 (3) ◽  
Author(s):  
Robert Skibiński ◽  
Łukasz Komsta ◽  
Marta Grech-Baran ◽  
Anna Gumieniczek

AbstractThe LBOZ criterion is an interesting approach for quantifying selectivity during spectrophotometric analysis by measuring the relative uncertainty increase caused by spectral overlapping. Unfortunately, no reference values for pharmaceuticals analysis in the UV region exist. The current paper presents an estimation of the LBOZ distribution as a random variable for binary and ternary drug mixtures. The estimation was done on a representative group of 170 diverse drug-like compounds. Results of the estimation were fitted to the beta and the Johnson distributions. The obtained parameters can be used to examine the “significance” of the spectral overlap by finding the p-value, interpreted as a chance to obtain higher uncertainty increase among the drugs.



2018 ◽  
Vol 15 (1) ◽  
pp. 63-72
Author(s):  
Baghdad Science Journal

Four electrodes were synthesized based on molecularly imprinted polymers (MIPs). Two MIPs were prepared by using the diclofenac sodium (DFS) as the template, 2-hydroxy ethyl metha acrylate(2-HEMA) and 2-vinyl pyridine(2-VP) as monomers as well as divinyl benzene and benzoyl peroxide as cross linker and initiator respectively. The same composition used for prepared non-imprinted polymers (NIPs) but without the template (diclofenac sodium). To prepared the membranes electrodes used different plasticizers in PVC matrix such as: tris(2-ethyl hexyl) phosphate (TEHP), tri butyl phosphate (TBP), bis(2-ethyl hexyl) adipate (BEHA) and tritolyl phosphate (TTP). The characteristics studied the slop, detection limit, life time and linearity range of DFS–MIPs electrodes. The results were obtained from selectivity measurements on amino acids showed good response as well as pharmaceuticals analysis.



2020 ◽  
Vol 16 ◽  
Author(s):  
Burcu Dogan Topal ◽  
Ceren Elif Sener ◽  
Basak Kaya ◽  
Sibel Aysıl Ozkan

: Electrochemical analysis offers a number of important advantages such as providing information on pharmaceuticals analysis and their in vivo redox processes, and pharmacological activity. The interest in developing electrochemical sensing devices for use in clinical assays is growing rapidly. Metallic nanoparticles can be synthesized and modified with various chemical functional groups, which allow them to be conjugated with antibodies, ligands, and drugs of interest. In this article, the novel developments to enhance of the performance of sensor modified with metal nanoparticles of pharmaceuticals were reviewed. A discussion of the properties of metal nanostructures and their application in drug analysis is presented. Their application as modifier agent in determining low levels of drugs in pharmaceutical dosage forms and biological samples are discussed. It has been found that the electrocatalytic effect of the electrode, sensitivity and selectivity were increased using various working electrodes modified with nano-sized metal, metal oxide and metal / metal oxide particles.





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