Ellagic acid production by solid-state fermentation influenced by the inert solid supports

Ellagic acid and ellagitannins are defense phytochemicals and dietary polyphenols found in fruits and nuts and implicated with strong antioxidant, anticancer and antiatherosclerotic biological properties. Unfortunately, there are few reports on the bioconversion studies from ellagitannins to ellagic acid. The objective of the present work was to use of partially purified ellagitannins from pomegranate peels as inducers for production of ellagic acid by Aspergillus niger GH1 in solid-state fermentation on inert supports (perlite, polyurethane foam and nylon fiber). For total pomegranate polyphenols (TPP), two methodologies were compared. Higher recovery of TTP (70 g kg-1 peel) in a short time (2 h) were obtained by filtering through a muslin cloth followed by centrifugation at 3000 rpm for 15 min. Production of ellagic acid and ellagitannase enzyme were evaluated. Maximum ellagic acid production (231.22 mg g-1 TPP) at 24 h cultivation with an ellagitannase activity of 3213 U L-1 was obtained when using polyurethane foam as inert support. Polyurethane foam was the best solid support to produce high yields of ellagic acid production.

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Exploring the Degradation of Gallotannins Catalyzed by Tannase Produced by Aspergillus niger GH1 for Ellagic Acid Production in Submerged and Solid-State Fermentation

Applied Biochemistry and Biotechnology ◽

10.1007/s12010-017-2663-5 ◽

2017 ◽

Vol 185 (2) ◽

pp. 476-483 ◽

Cited By ~ 3

Author(s):

Mónica L. Chávez-González ◽

Sylvain Guyot ◽

Raul Rodríguez-Herrera ◽

Arely Prado-Barragán ◽

Cristóbal N. Aguilar

Keyword(s):

Solid State ◽

Aspergillus Niger ◽

Solid State Fermentation ◽

Ellagic Acid ◽

Acid Production ◽

Aspergillus Niger Gh1

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Ellagic acid production by Aspergillus niger in solid state fermentation of pomegranate residues

Journal of Industrial Microbiology & Biotechnology ◽

10.1007/s10295-008-0309-x ◽

2008 ◽

Vol 35 (6) ◽

pp. 507-513 ◽

Cited By ~ 66

Author(s):

Armando Robledo ◽

Antonio Aguilera-Carbó ◽

Raúl Rodriguez ◽

José Luis Martinez ◽

Yolanda Garza ◽

...

Keyword(s):

Solid State ◽

Aspergillus Niger ◽

Solid State Fermentation ◽

Ellagic Acid ◽

Acid Production

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Clavulanic Acid Production by Streptomyces clavuligerus using Solid State Fermentation on Polyurethane Foam

Trends in Renewable Energy ◽

10.17737/tre.2016.2.1.0018 ◽

2016 ◽

pp. 2-12

Author(s):

Hui Wang ◽

Hongzhang Chen

Keyword(s):

Solid State ◽

Clavulanic Acid ◽

Polyurethane Foam ◽

Solid State Fermentation ◽

Acid Production ◽

Streptomyces Clavuligerus

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On-line monitoring of Aspergillus niger GH1 growth in a bioprocess for the production of ellagic acid and ellagitannase by solid-state fermentation

Bioresource Technology ◽

10.1016/j.biortech.2017.09.115 ◽

2018 ◽

Vol 247 ◽

pp. 412-418 ◽

Cited By ~ 3

Author(s):

Pedro Aguilar-Zárate ◽

Jorge E. Wong-Paz ◽

Luis V. Rodríguez-Duran ◽

Juan Buenrostro-Figueroa ◽

Mariela Michel ◽

...

Keyword(s):

Solid State ◽

Aspergillus Niger ◽

Solid State Fermentation ◽

Ellagic Acid ◽

On Line ◽

Aspergillus Niger Gh1

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The Molecular Diversity Scope of Urazole in the Synthesis of Organic Compounds

Current Organic Synthesis ◽

10.2174/1570179416666190925162215 ◽

2019 ◽

Vol 16 (7) ◽

pp. 953-967 ◽

Cited By ~ 1

Author(s):

Ghodsi M. Ziarani ◽

Fatemeh Mohajer ◽

Razieh Moradi ◽

Parisa Mofatehnia

Keyword(s):

Biological Activities ◽

Biological Properties ◽

Biologically Active ◽

Microtubule Assembly ◽

Heterocyclic Molecules ◽

Biological Perspective ◽

Highly Active ◽

Anti Inflammatory ◽

High Yields ◽

Short Time

Background: As a matter of fact, nitrogen as a hetero atom among other atoms has had an important role in active biological compounds. Since heterocyclic molecules with nitrogen are highly demanded due to biological properties, 4-phenylurazole as a compound containing nitrogen might be important in the multicomponent reaction used in agrochemicals, and pharmaceuticals. Considering the case of fused derivatives “pyrazolourazoles” which are highly applicable because of their application for analgesic, antibacterial, anti-inflammatory and antidiabetic activities as HSP-72 induction inhibitors (I and III) and novel microtubule assembly inhibitors. It should be mentioned that spiro-pyrazole also has biological activities like cytotoxic, antimicrobial, anticonvulsant, antifungal, anticancer, anti-inflammatory, and cardiotonic activities. Objective: Urazole has been used in many heterocyclic compounds which are valuable in organic syntheses. This review disclosed the advances in the use of urazole as the starting material in the synthesis of various biologically active molecules from 2006 to 2019. Conclusion: Compounds of urazole (1,2,4-triazolidine-3,5-dione) are the most important molecules which are highly active from the biological perspective in the pharmaceuticals as well as polymers. In summary, many protocols for preparations of the urazole derivatives from various substrates in multi-component reactions have been reported from different aromatic and aliphatic groups which have had carbonyl groups in their structures. It is noted that several catalysts have been synthesized to afford applicable molecules with urazole scaffolds. In some papers, being environmentally friendly, short time reactions and high yields are highlighted in the protocols. There is a room to synthesize new catalysts and perform new reactions by manipulating urazole to produce biologically active compounds, even producing chiral urazole component as many groups of chiral urazole compounds are important from biological perspective.

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