scholarly journals Co-Administration of Crude Ethanolic Leaf Extract of Ageratum conyzoides ameliorates Nigerian Bonnylight Crude Oil-Induced Erythrocyte Haemolysis in Female Wistar Rats

2017 ◽  
Vol 12 (03) ◽  
pp. 73-77
Author(s):  
Ita, S. O ◽  
Nya, M. E
Keyword(s):  
Crude Oil ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Ageratum Conyzoides ◽  
Female Wistar Rats ◽  
Ethanolic Leaf Extract ◽  
Erythrocyte Haemolysis

scholarly journals Antidiarrheal Activity of Dissotis multiflora (Sm) Triana (Melastomataceae) Leaf Extract in Wistar Rats and Subacute Toxicity Evaluation

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Alian Désiré Afagnigni ◽  
Maximilienne Ascension Nyegue ◽  
Chantal Florentine Ndoye Foe ◽  
Youchahou Njankouo Ndam ◽  
Frédéric Nico Njayou ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Leaf Extract ◽  
Shigella Flexneri ◽  
Female Rats ◽  
Male Rats ◽  
Dependent Manner ◽  
Subacute Toxicity ◽  
Antidiarrheal Activity ◽  
Dose Dependent ◽  
Ethanolic Leaf Extract

The present work was undertaken to evaluate antidiarrheal activity of ethanolic leaf extract of Dissotis multiflora (Sm) Triana (D. multiflora) on Shigella flexneri-induced diarrhea in Wistar rats and its subacute toxicity. Diarrhea was induced by oral administration of 1.2 × 109 cells/mL S. flexneri to rats. Antidiarrheal activity was investigated in rats with the doses of 111.42 mg/kg, 222.84 mg/kg, and 445.68 mg/kg. The level of biochemical parameters was assessed and organs histology examined by 14 days’ subacute toxicity. S. flexneri stool load decreased significantly in dose-dependent manner. The level of ALT increased (p<0.05) in male rats treated with the dose of 445.68 mg/kg while creatinine level increased in rats treated with both doses. In female rats, a significant decrease (p<0.05) of the level of AST and creatinine was noted in rats treated with the dose of 222.84 mg/kg of D. multiflora. Histological exams of kidney and liver of treated rats showed architectural modifications at the dose of 445.68 mg/kg. This finding suggests that D. multiflora leaf extract is efficient against diarrhea caused by S. flexneri but the treatment with doses lower than 222.84 mg/kg is recommended while further study is required to define the exact efficient nontoxic dose.

scholarly journals Reproductive Function Evaluation in Female Wistar Rats Treated with Aqueous leaf Extract of Cissusaralioides

2019 ◽  
Vol 16 (04) ◽  
pp. 857-864
Author(s):  
Bartholomew Chukwuebuka Nwogueze ◽  
Anthony Emeka Ojieh ◽  
Richard Nduka Ossai ◽  
ChidinmaNwanneamaka Eke
Keyword(s):  
Wistar Rats ◽  
Leaf Extract ◽  
Reproductive Function ◽  
Function Evaluation ◽  
Eastern Region ◽  
Body Weight Reduction ◽  
Therapeutic Benefits ◽  
The Family ◽  
Female Wistar Rats ◽  
Aqueous Leaf Extract

ABSTRACT: Background: Medicinal plants are increasingly getting recognition. Cissus aralioides is a lofty climber belonging to the family of Vitaceae and widely distributed in South-Eastern region of Nigeria. Varied therapeutic benefits as well as well health harming effects have been reported about the plant. This study evaluated the effects of aqueous extract of Cissus aralioides leaf on reproductive functions in female Wistar rats.Methods: 72 adult female Wistar rats weighing between 110-180/g were used for the study. The animals were randomly grouped into 6 groups of twelve rats each (n=12). Groups 1 and 2 served as control while groups 3 to 6 were the experimental groups and were administered (100/mg, 200/mg, 300/mg and 500/mg)/kg of the extract respectively for 4 weeks. At the end of the experiment, blood samples were collected and centrifuged to obtain the serum for biochemical analysis for Follicle Stimulating Hormone (FSH), Estrogen and Luteinizing Hormone (LH). Data were analyzed using the SPSS package and expressed as mean± SEM and ANOVA.Results: There was significant body weight reduction across groups administered with the extract. Also, there were significant decrease in estrogen level in groups that received 300/mg/kg and 500/mg/kg when compared with the control groups, a similar decrease was not observed with LH and FSH across the groups.Conclusion: Observations from this study shows that aqueous leaf extract of Cissus aralioides decreases circulating levels of estrogen in female Wistar rats.

scholarly journals Effect of Crude Ethanolic Leaf Extract of Rauwolfia Vomitoria on the Fetal Lungs of Wistar Rats

2014 ◽  
Vol 5 (1) ◽  
pp. 1-7
Author(s):  
Mokutima Eluwa ◽  
Kenneth Osim ◽  
Moses Ekong ◽  
Theresa Ekanem ◽  
Amabe Akpantah ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Leaf Extract ◽  
Fetal Lungs ◽  
Ethanolic Leaf Extract ◽  
Rauwolfia Vomitoria
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