Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI

Several techniques are under development for image-guidance in particle therapy. Positron (β+) emission tomography (PET) is in use since many years, because accelerated ions generate positron-emitting isotopes by nuclear fragmentation in the human body. In heavy ion therapy, a major part of the PET signals is produced by β+-emitters generated via projectile fragmentation. A much higher intensity for the PET signal can be obtained using β+-radioactive beams directly for treatment. This idea has always been hampered by the low intensity of the secondary beams, produced by fragmentation of the primary, stable beams. With the intensity upgrade of the SIS-18 synchrotron and the isotopic separation with the fragment separator FRS in the FAIR-phase-0 in Darmstadt, it is now possible to reach radioactive ion beams with sufficient intensity to treat a tumor in small animals. This was the motivation of the BARB (Biomedical Applications of Radioactive ion Beams) experiment that is ongoing at GSI in Darmstadt. This paper will present the plans and instruments developed by the BARB collaboration for testing the use of radioactive beams in cancer therapy.

Yttrium Oxide Freeze-Casts: Target Materials for Radioactive Ion Beams

Highly porous yttrium oxide is fabricated as ion beam target material in order to produce radioactive ion beams via the Isotope Separation On Line (ISOL) method. Freeze casting allows the formation of an aligned pore structure in these target materials to improve the isotope release. Aqueous suspensions containing a solid loading of 10, 15, and 20 vol% were solidified with a unidirectional freeze-casting setup. The pore size and pore structure of the yttrium oxide freeze-casts are highly affected by the amount of solid loading. The porosity ranges from 72 to 84% and the crosslinking between the aligned channels increases with increasing solid loading. Thermal aging of the final target materials shows that an operation temperature of 1400 °C for 96 h has no significant effect on the microstructure. Thermo-mechanical calculation results, based on a FLUKA simulation, are compared to measured compressive strength and forecast the mechanical integrity of the target materials during operation. Even though they were developed for the particular purpose of the production of short-lived radioactive isotopes, the yttria freeze-cast scaffolds can serve multiple other purposes, such as catalyst support frameworks or high-temperature fume filters.

Proof of Concept Experience in the SPES Experiment: First Solutions for Potentiometers Replacement in System Maintenance

SPES (Selective Production of Exotic Species) is a large facility, currently under advanced construction at the INFN-LNL (Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro) for the production of Radioactive Ion Beams (RIBs). Coordinated efforts are being dedicated to the development and upgrading of both the accelerator complex and the up-to-date experimental set-ups. This paper describes a work of upgrading as far as the inspection and maintenance of the system is concerned, and it deals with human-centered design methods to reduce the time spent in the radioactive environment of the facility during ordinary maintenance operations and to simplify them, also considering stress conditions of the operator and the mandatory wearable radiation protection devices (such as tracksuit, gloves, oxygen tank mask) which make simple operations difficult.

Production and Separation of Radioactive Ion Beams

Radioactive nuclei play an important role in many astrophysical scenarios,from the Big-Bang Nucleo-synthesis to the standard solar model, from quiescent burning to the most explosive events that can occur in our universe. A huge effort has been made for more than thirty years to construct facilities able to deliver beams of radioactive nuclei with increasing intensity and better quality. This contribution revises the different mechanisms and the separation techniques employed for the production of Radioactive Ion Beams.