Strongly Correlated Electronic States in Aqueous Micellar Surfactant

Strongly correlated electronic states (SCES), that determine the anomalies of physicochemical properties, are well-known for solid materials at low temperatures. According to the mechanism of manifestation their existence can be assumed in biological cells with white spots, which makes us look into this challenging problem in detail. The paper presents its solution through a study of simple models of micellar solutions of ionic surfactants. The process of micelle formation with accompanying liquid-liquid phase transition makes us pay attention to possible anomalies of properties. Therefore the SCES of water micellar solution has been tested by compenstion and cooperative effects; and by small-angle, wide-angle X-ray, dynamic and chiral scattering of electromagnetic radiation. The solution water is represented by ensembles of small nano systems. Therefore, thermal (cavities for micelles 2-6 nm) and quantum (0.2-0.3 nm) fluctuations of water appear in the zone of concentration of micelle formation. Their energy is approximately equal to the H-bond. Contraction (expansion) of water H-bonds network of due to quantum fluctuations on a small scale correlates with the expansion (contraction) of the in the cavities in the micelles H-bonds network due to thermal fluctuations on a large scale. This phenomenon is caused by SСES.

Solubilization and thermodynamic properties of simvastatin in various micellar solutions of different non-ionic surfactants: Computational modeling and solubilization capacity

The aim of this work was to solubilize simvastatin (SIM) using different micellar solutions of various non-ionic surfactants such as Tween-80 (T80), Tween-20 (T20), Myrj-52 (M52), Myrj-59 (M59), Brij-35 (B35) and Brij-58 (B58). The solubility of SIM in water (H2O) and different micellar concentrations of T80, T20, M52, M59, B35 and B58 was determined at temperatures T = 300.2 K to 320.2 K under atmospheric pressure p = 0.1 MPa using saturation shake flask method. The experimental solubility data of SIM was regressed using van’t Hoff and Apelblat models. The solubility of SIM (mole fraction) was recorded highest in M59 (1.54 x 10−2) followed by M52 (6.56 x 10−3), B58 (5.52 x 10−3), B35 (3.97 x 10−3), T80 (1.68 x 10−3), T20 (1.16 x 10−3) [the concentration of surfactants was 20 mM in H2O in all cases] and H2O (1.94 x 10−6) at T = 320.2 K. The same results were also recorded at each temperature and each micellar concentration of T80, T20, M52, M59, B35 and B58. “Apparent thermodynamic analysis” showed endothermic and entropy-driven dissolution/solubilization of SIM in H2O and various micellar solutions of T80, T20, M52, M59, B35 and B58.