An Automatic Approach for Individual HU-Based Characterization of Lungs in COVID-19 Patients

The ongoing COVID-19 pandemic currently involves millions of people worldwide. Radiology plays an important role in the diagnosis and management of patients, and chest computed tomography (CT) is the most widely used imaging modality. An automatic method to characterize the lungs of COVID-19 patients based on individually optimized Hounsfield unit (HU) thresholds was developed and implemented. Lungs were considered as composed of three components—aerated, intermediate, and consolidated. Three methods based on analytic fit (Gaussian) and maximum gradient search (using polynomial and original data fits) were implemented. The methods were applied to a population of 166 patients scanned during the first wave of the pandemic. Preliminarily, the impact of the inter-scanner variability of the HU-density calibration curve was investigated. Results showed that inter-scanner variability was negligible. The median values of individual thresholds th1 (between aerated and intermediate components) were −768, −780, and −798 HU for the three methods, respectively. A significantly lower median value for th2 (between intermediate and consolidated components) was found for the maximum gradient on the data (−34 HU) compared to the other two methods (−114 and −87 HU). The maximum gradient on the data method was applied to quantify the three components in our population—the aerated, intermediate, and consolidation components showed median values of 793 ± 499 cc, 914 ± 291 cc, and 126 ± 111 cc, respectively, while the median value of the first peak was −853 ± 56 HU.

APPLICATION OF THE SPH EQUIVALENCE TECHNIQUE TO THE CABRI FULL CORE IN NON-FUNDAMENTAL MODE

We developed a SPH equivalence technique in non-fundamental mode condition between a CABRI full-core model solved with the method of characteristics (MOC) in 2D and a simplified full-core model solved with the simplified P3 (SP3) method, linear anisotropic sources and discretized with Raviart-Thomas finite elements over a pure Cartesian mesh. The MOC and SP3 calculations are performed with DRAGON5 and DONJON5 codes, respectively. A three-parameter database is generated by DRAGON5 and is interpolated in DONJON5 as a function of the core condition. An objective function is set as the root mean square (RMS) error (MOC-SP3 discrepancy) on absorption distribution and leakage rates defined over the macro-geometry in DONJON5. Our algorithm is a quasi-Newtonian gradient search based on the Limited memory Broyden-Fletcher-Goldfarb-Shanno (LBFGS) method. Numerical results are presented with Hafnium bars withdrawn or inserted.