Decitabine combined regimen in the therapy of Blastic plasmacytoid dendritic cell neoplasm: case report

We enrolled a patient diagnosed with blastic plasmacytoid dendritic cell neoplasm (BPDCN) . We have found that TET2, KRAS and BRAF may be involved in the development of the disease, and the combination therapy of Decitabine (DAC) and Arsenic acid (ASO) may be effective for BPDCN harboring the TET2 mutations.

Breast Cancer Disease and Arsenic: “Geological Behavior (GBR) as Key “

Geology may appear remote from human health. However, rocks are the fundamental building blocks of the Earth’s surface, full of important minerals and chemical elements. Rock weathering and alteration products not only form our soils to support our crops but provide essential elements to build biology. Some heavy metals are carcinogenic, and some only affect the body’s ability to produce red and white cells. In fact, any heavy metal affects any part of the body due to our geological behavior (GBR). For example, a heavy metal may not cause any side effects by contact with the skin, even when swallowed, and may not cause serious harm, but inhaling the vapor of that heavy, toxic metal can cause severe damage to the lungs. Some heavy and quasi metals are more toxic, and some forms of heavy metal compounds are even more dangerous than other forms. Toxic and hazardous heavy metals like arsenic, lead, mercury, zinc, chromium and iron are found in a variety of personal care products, e.g., lipstick, whitening toothpaste, eyeliner and nail color. We use the Anodic Stripping voltammetry (ASV) method for arsenic detection, utilizing the PDV6000 + analyzer (Manufactured B3 Electronics, Perth Australia) configured with a solid gold electrode for total as analyses. Sample Preparation: Spot urine samples were collected from most of the participants from 1 January 2018 to 30 March 2020 after face to face interviews. Women with missing information on adjustment variable(s) were included in the analysis in a separate category for adjustment. Results: Our studies were focus in describing the mean Urinary Arsenic levels (u As) residents of in the central zones of Shiraz, Fasa, Abadeh, Jahrom and Marvdasht to compare the effect of diet such as consuming canned or frozen foods, Consume rice daily, smoking habits and lifestyle on the incidence of Breast. Conclusion: Cancer with arsenic compounds has been reported in many parts of the world. The disease affects all organs of the body, and every year many victims of cancer suffer from severe symptoms and even death. Arsenic compounds are present in the human body and environment in an inorganic and organic form. Inorganic arsenic includes arsenite and arsenic, can also be presented in the environment in the form of methyl (monthly arsenic acid and dimethyl arsenic acid). Arsenic, especially inorganic arsenic, is well absorbed through the gastrointestinal tract rivers (80% -90%) and will be scattered throughout the body. It is often metabolized by methylation and excreted mainly in the urine. Methylation of inorganic arsenic compounds is said to undergo a detoxification process.

Arsenates of Divalent Metals Comprising Arsenic Acid—An Update

Divalent metal oxidoarsenates(V) with compositions M(H2AsO4)2(H3AsO4)2 (M = Mg, Mn, Co, Ni), M(HAsO4)(H3AsO4)(H2O)0.5 (M = Mn, Cd) and Zn(HAsO4)(H3AsO4) were obtained from solutions containing an excess of arsenic acid. Single crystal X-ray diffraction revealed isotypism of the M(H2AsO4)2(H3AsO4)2 (M = Mg, Mn, Co, Ni) structures with the known Cu and Zn members of this series whereas M(HAsO4)(H3AsO4)(H2O)0.5 (M = Mn, Cd) and Zn(HAsO4)(H3AsO4) crystallize in novel structure types. The two isotypic M(HAsO4)(H3AsO4)(H2O)0.5 (M = Mn, Cd) structures are closely related with that of Zn(HAsO4)(H3AsO4). Both comprise undulating centrosymmetric 1[MO4/2O2/1] chains that share corners with HAsO42− tetrahedra and H3AsO4 tetrahedra to build up layers extending along (001). Intermediate water molecules (occupancy 0.5) link adjacent layers in the water-containing compound whereas the linkage in the Zn-compound is mediated by weak hydrogen bonding interactions between the layers. Results of a quantitative comparison between all known structures of the M(H2XO4)2(H3XO4)2 (M = Mg, Mn, Co, Ni, Cu, Zn; X = P, As) series as well as between the two M(HAsO4)(H3AsO4)(H2O)0.5 (M = Mn, Cd) structures are presented.

Anion Inhibition Profile of the β-Carbonic Anhydrase from the Opportunist Pathogenic Fungus Malassezia Restricta Involved in Dandruff and Seborrheic Dermatitis

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, which catalyze the crucial physiological CO2 hydration/dehydration reaction (CO2 + H2O ⇌ HCO3− + H+) balancing the equilibrium between CO2, H2CO3, HCO3− and CO32−. It has been demonstrated that their selective inhibition alters the equilibrium of the metabolites above affecting the biosynthesis and energy metabolism of the organism. In this context, our interest has been focalized on the fungus Malassezia restricta, which may trigger dandruff and seborrheic dermatitis altering the complex bacterial and fungal equilibrium of the human scalp. We investigated a rather large number of inorganic metal-complexing anions (a well-known class of CA inhibitors) for their interaction with the β-CA (MreCA) encoded by the M. restricta genome. The results were compared with those obtained for the two human ?-CA isoforms (hCAI and hCAII) and the β-CA from Malassezia globosa. The most effective MreCA inhibitors were diethyldithiocarbamate, sulfamide, phenyl arsenic acid, stannate, tellurate, tetraborate, selenocyanate, trithiocarbonate, and bicarbonate. The different KI values obtained for the four proteins investigated might be attributed to the architectural features of their catalytic site. The anion inhibition profile is essential for better understanding the inhibition/catalytic mechanisms of these enzymes and for designing novel types of inhibitors, which may have clinical applications for the management of dandruff and seborrheic dermatitis.