Delayed Anticipatory Muscle Activation in Rotator Cuff Tendinopathy

Background: Previous research investigating rotator cuff (RC) tendinopathy has usually focused on pathoanatomy. The pathologic response to anticipatory postural adjustments (APAs) has not yet been investigated. Purpose/Hypothesis: To explore changes in APAs as detected by pre-emptive activation of shoulder muscles during ball catching. It was hypothesized that anticipatory muscle activation (AMA) would be present in the unaffected shoulder but delayed or absent in the affected shoulder in patients with RC tendinopathy. Study Design: Controlled laboratory study. Methods: This study included 21 RC tendinopathy patients with a mean age of 49.5 years. Patients were required to grab a ball embedded with an electromyography sensor when it dropped on their hand, and surface electromyography signals were recorded from the infraspinatus, upper trapezius, anterior deltoid, and biceps. The trials utilized 2 balls, weighing 200 g and 500 g. Each ball was used in 2 trials, 1 involving a number count preceding the ball drop (predictable) and the other involving a sudden drop (unpredictable). The onsets of AMA between the affected and unaffected limbs were compared. Results: Regardless of the experimental condition, significantly delayed AMA onsets were identified in all investigated muscles of the affected side compared with those of the unaffected side, except for the biceps muscle in the 500-g predictable trial. For the infraspinatus, the mean onset time in the 200-g predictable trial was –141.0 ± 60.2 ms on the affected side and –211.9 ± 67.1 ms on the unaffected side ( P < .001); in the 200-g unpredictable trial this value was –139.5 ± 54.9 ms on the affected side and –199.5 ± 56.2 ms on the unaffected side ( P < .001). Conclusion: Delayed AMA was observed in the affected shoulder compared with the unaffected shoulder in patients with RC tendinopathy, not only in the RC muscle but also in the periscapular and upper arm muscles. This may indicate that central hypoexcitability is partly responsible. Clinical Relevance: The basis for RC tendinopathy treatment should not be limited to the tendon pathoanatomy. Delayed AMA around the shoulder joint could provide insight into potential mechanisms related to the central nervous system.

Arctic Sea Ice’s Amplification as a Complement to Anthropogenic Global Warming

Climate Change is a widely debated scientific subject and Anthropogenic Global Warming is its main cause. Nevertheless, several authors have indicated solar activity and Atlantic Multi-decadal Oscillation variations may also influence Climate Change. This article considers the amplification of solar radiation’s and Atlantic Multi-decadal Oscillation’s variations, via sea ice cover albedo feedbacks in the Arctic regions, providing a conceptual advance in the application of Arctic Amplification for modelling historical climate change. A 1-dimensional physical model, using sunspot number count and Atlantic Multi-decadal Oscillation index as inputs, can simulate the average global temperature’s anomaly and the Arctic Sea Ice Extension for the past eight centuries. This model represents an innovative progress in understanding how existing studies on Arctic sea ice’s albedo feedbacks can help complementing the Anthropogenic Global Warming models, thus helping to define more precise models for future climate change.

Did Sgr cause the vertical waves in the solar neighbourhood?

ABSTRACT The vertical distribution of stars in the solar neighbourhood is not in equilibrium but contains a wave signature in both density and velocity space originating from a perturbation. With the discovery of the phase-space spiral in Gaia data release (DR) 2, determining the origin of this perturbation has become even more urgent. We develop and test a fast method for calculating the perturbation from a passing satellite on the vertical component of a part of a disc galaxy. This fast method allows us to test a large variety of possible perturbations to the vertical disc very quickly. We apply our method to the range of possible perturbations to the solar neighbourhood stemming from the recent passage of the Sagittarius dwarf galaxy (Sgr), varying its mass, mass profile, and present-day position within their observational uncertainties, and its orbit within different realistic models for the Milky Way’s gravitational potential. We find that we are unable to reproduce the observed asymmetry in the vertical number counts and its concomitant breathing mode in velocity space for any plausible combination of Sgr and Milky Way properties. In all cases, either the amplitude or the perturbation wavelength of the number-count asymmetry and of the oscillations in the mean vertical velocity produced by the passage of Sgr are in large disagreement with the observations from Gaia DR2. We conclude that Sgr cannot have caused the observed oscillations in the vertical disc or the Gaia phase-space spiral.

Removing the giants and learning from the crowd: A new SZ power spectrum method and revised Compton y-map analysis

The Sunyaev-Zeldovich (SZ) effect provides a powerful cosmological probe, which traditionally is approached independently as cluster number count (CNC) or power spectrum (PS) analysis. Here, we devise a new method for analysing the y-map by introducing the survey completeness function, conventionally only used in the CNC analysis, in the yy-PS modeling. This provides a systematic method, based mainly on SZ observables, for obtaining two complementary y-maps, one incorporating detected/resolved clusters and the other relying only on diffuse/unresolved SZ contributions. We use the catalogue of clusters obtained in the Planck CNC analysis to define the completeness function linking these two y-maps. The split depends on the chosen signal-to-noise detection threshold, which we vary in our discussion. We carefully propagate the effect of completeness cuts on the non-Gaussian error contributions in the yy-PS analysis, highlighting the benefits of masking massive clusters. Our analysis of the Planck yy-PS for the unresolved component yields a mass bias of b = 0.15 ± 0.04, consistent with the standard value (b ≈ 0.2), in comparison to b = 0.4 ± 0.05 for the total yy-PS. We find indications for this drift being driven by the CIB-tSZ cross correlation, which dominantly originates from clusters in the resolved component of the y-map. Another possible explanation is the presence of a mass-dependent bias, which has been theoretically motivated and can be quantified with our novel method. We furthermore find first hints for the presence of the 2-halo terms in the yy-PS. Finally, the proposed method provides a new framework for combining the complementary information of the CNC and PS analyses in upcoming SZ surveys.

Ameliorative effect of recombinant human lactoferrin on the premature ovarian failure in rats after cyclophosphamide treatments

This study investigated the effect of recombinant human lactoferrin (rhLF) on the premature ovarian failure (POF) of rats. After cyclophosphamide treatments, the POF rats were divided into the following groups: normal control group (NC), low-dose group (LD), medium-dose group (MD) and high-dose group (HD) of rhLF. After drug administrations, the ovarian indexes and hormonal levels were detected. After follicle number count, the proliferation and apoptosis were analyzed with the expressions of genes related with oogenesis, reactive oxygen species (ROS) production and apoptosis detected, followed by the calculation of oxidative stress and protein expressions. After 4-hydroperoxy cyclophosphamide (4-HC) treatments, the effect of rhLF on the proliferation, ROS production and gene expressions of primary rat granulosa cells (GCs) cultured in vitro were detected. After mating, the fertilities of POF rats were recorded. The result showed that the rhLF administrations up-regulated the ovarian index with the number of developing follicles increased and the decreases of hormonal levels conferred. The Ki-67 intensities of the MD and HD groups were up-regulated with the Tunnel intensities decreased. The rhLF treatments significantly promoted the expression of oogenesis, antioxidant and anti-apoptosis related genes. The expression of Bax and Caspase 3 were decreased with the expression of Bcl-2 up-regulated after rhLF administrations. The in vitro treatments of rhLF effectively conferred the toxicity of 4-HC on primary rat GCs. The fertility assessment showed the rhLF treatments up-regulated the offspring’s’ folliculogenesis, which confirmed the ameliorative role of rhLF on the POF damages via the inhibition of ROS production in GCs.

Inferring the properties of the sources of reionization using the morphological spectra of the ionized regions

ABSTRACT High-redshift 21-cm observations will provide crucial insights into the physical processes of the Epoch of Reionization. Next-generation interferometers such as the Square Kilometer Array will have enough sensitivity to directly image the 21-cm fluctuations and trace the evolution of the ionizing fronts. In this work, we develop an inferential approach to recover the sources and IGM properties of the process of reionization using the number and, in particular, the morphological pattern spectra of the ionized regions extracted from realistic mock observations. To do so, we extend the Markov Chain Monte Carlo analysis tool 21cmmc by including these 21-cm tomographic statistics and compare this method to only using the power spectrum. We demonstrate that the evolution of the number-count and morphology of the ionized regions as a function of redshift provides independent information to disentangle multiple reionization scenarios because it probes the average ionizing budget per baryon. Although less precise, we find that constraints inferred using 21-cm tomographic statistics are more robust to the presence of contaminants such as foreground residuals. This work highlights that combining power spectrum and tomographic analyses more accurately recovers the astrophysics of reionization.

Galaxy clusters as intrinsic alignment tracers: present and future

ABSTRACT Galaxies and clusters embedded in the large-scale structure of the Universe are observed to align in preferential directions. Galaxy alignment has been established as a potential probe for cosmological information, but the application of cluster alignments for these purposes remains unexplored. Clusters are observed to have a higher alignment amplitude than galaxies, but because galaxies are much more numerous, the trade-off in detectability between the two signals remains unclear. We present forecasts comparing cluster and galaxy alignments for two extragalactic survey set-ups: a currently available low-redshift survey (Sloan Digital Sky Survey, SDSS) and an upcoming higher redshift survey (Legacy Survey of Space and Time, LSST). For SDSS, we rely on the publicly available redmapper catalogue to describe the cluster sample. For LSST, we perform estimations of the expected number counts while we extrapolate the alignment measurements from SDSS. Clusters in SDSS have typically higher alignment signal-to-noise ratio (S/N) than galaxies. For LSST, the cluster alignment signals quickly wash out with redshift due to a relatively low number count and a decreasing alignment amplitude. Nevertheless, a potential strong suit of clusters is in their interplay with weak lensing: intrinsic alignments can be more easily isolated for clusters than for galaxies. The S/N of cluster alignment can in general be improved by isolating close pairs along the line of sight.

Searching for cross-correlation between stochastic gravitational-wave background and galaxy number counts

ABSTRACT Advanced Laser Interferometer Gravitational-Wave Observatory (LIGO) and Advanced Virgo have recently published the upper limit measurement of persistent directional stochastic gravitational-wave background (SGWB) based on data from their first and second observing runs. In this paper, we investigate whether a correlation exists between this maximal likelihood SGWB map and the electromagnetic (EM) tracers of matter structure in the Universe, such as galaxy number counts. The method we develop will improve the sensitivity of future searches for anisotropy in the SGWB and expand the use of SGWB anisotropy to probe the formation of structure in the Universe. In order to compute the cross-correlation, we used the spherical harmonic decomposition of SGWB in multiple frequency bands and converted them into pixel-based sky maps in healpix basis. For the EM part, we use the Sloan Digital Sky Survey alaxy catalogue and form healpix sky maps of galaxy number counts at the same angular resolution as the SGWB maps. We compute the pixel-based coherence between these SGWB and galaxy count maps. After evaluating our results in different SGWB frequency bands and in different galaxy redshift bins, we conclude that the coherence between the SGWB and galaxy number count maps is dominated by the null measurement noise in the SGWB maps, and therefore not statistically significant. We expect the results of this analysis to be significantly improved by using the more sensitive upcoming SGWB measurements based on the third observing run of Advanced LIGO and Advanced Virgo.

Maxakalí has suppletion, numerals and associatives but no plurals

The Maxakalí language lacks additive plurals (akin to dog-s) on nouns, but has associative plurals, and a large set of suppletive verbs that indicate whether the internal argument is plural or not. Although it has no plural marking, Maxakalí distinguishes between count nouns and mass nouns. The former can be followed by numerals, while the latter must be coerced or occur with container words. Only count nouns can be distinguished between singular and plural with verbal number. Mass nouns always require plural verbal number. Count nouns are compatible with words like ‘many’ indicating cardinality, while mass nouns are compatible with words like ‘big’ for volume. Granulated substances have variable behavior, depending on whether treated as a whole or as several individuated items. Numerals in Maxakalí show an unusual pattern, whereby 1–3 are treated as unaccusative verbs, and 4 and up, being loanwords, are treated as unergative verbs.