A “School Of Clinical Ethics”: Clinical Ethics Education for Clinicians and Philosophy Students

"The presentation intends to present and illustrate an experience of teaching clinical ethics realized with a group of clinicians and philosophy students and held at the Philosophy Department of the University of Trento, Italy (Spring 2013 and Spring 2015). The class was intended to train clinicians and students to the main concepts of clinical ethics and to a specific methodology to approach clinical matters with ethical and philosophical tools. The class offered a space and time of listening, confronting, debating and learning. The opportunity to dialogue and to reflect, starting form clinical cases presented by clinicians and to realize an ethical analysis of them, combining languages and competences, resulted extremely relevant for clinicians, for students involved and for the teachers themselves. It represented – as well – a first and previous step to start some action-research in specific clinical units, as the local Intensive Care Unit, the Transplantation Coordination Unit and the Mountain Medicine and Ethics Lab. "

The CDC HIV Outbreak Coordination Unit: Developing a Standardized, Collaborative Approach to HIV Outbreak Assessment and Response

The Centers for Disease Control and Prevention (CDC) and state, territorial, and local health departments have expanded efforts to detect and respond to HIV clusters and outbreaks in the United States. In July 2017, CDC created the HIV Outbreak Coordination Unit (OCU) to ensure consistent and collaborative assessment of requests from health departments for consultation or support on possible HIV clusters and outbreaks of elevated concern. The HIV OCU is a multidisciplinary, cross-organization functional unit within CDC’s Division of HIV/AIDS Prevention. HIV OCU members have expertise in areas such as outbreak detection and investigation, prevention, laboratory services, surveillance and epidemiology, policy, communication, and operations. HIV OCU discussions facilitate problem solving, coordination, and situational awareness. Between HIV OCU meetings, designated CDC staff members communicate regularly with health departments to provide support and assessment. During July 2017–December 2019, the HIV OCU reviewed 31 possible HIV clusters and outbreaks (ie, events) in 22 states that were detected by CDC, health departments, or local partners; 17 events involved HIV transmission associated with injection drug use, and other events typically involved sexual transmission or overall increases in HIV diagnoses. CDC supported health departments remotely or on site with planning and prioritization; data collection, management, and analysis; communications; laboratory support; multistate coordination; and expansion of HIV prevention services. The HIV OCU has augmented CDC’s support of HIV cluster and outbreak assessment and response at health departments and had important internal organizational benefits. Health departments may benefit from developing or strengthening similar units to coordinate detection and response efforts within and across public health agencies and advance the national Ending the HIV Epidemic initiative.

RooT37 – CUTA’s TRA Tool in Response to a Changing Threat Landscape

In this chapter the authors discuss the establishment of the Belgian ‘Coordination Unit for Threat Analysis’ (CUTA), its remits and fields of competence and how its scope was widened in the last few years because of changes in the threat landscape of problematic radicalization, extremism and terrorism and the changing tactics of the Belgian government to tackle them. In the second part of this chapter the authors elaborate on ‘RooT37’, a risk assessment tool that was tailor-made by CUTA to address its newly assigned tasks in the framework of the revised Belgian Action Plan on Radicalism. The tool takes several risk indicators into account to aid CUTA’s experts in making structured professional judgments about threats and risks posed by monitored individuals, and semi-automatically produces a threat level. Furthermore, it provides CUTA’s support agencies with clues for further investigation based on discovered information gaps through the assessment. Finally, it also points out opportunities for coordinated intervention by partner services to reduce the risk posed by monitored individuals. Certain characteristics of the methodology of the tool are described in more detail, as well as its advantages and some challenges for the future.

Kynurenine-PARP 1 link mediated by microRNA 210 may be dysregulated in pulmonary hypertension

Background The aims of the present study were to determine the alterations in mRNA and miR expressions and their role in signaling pathways, to correlate their levels with the severity of PH, and to investigate the relationship between those alterations and serum levels of apelin, kynurenine, and endocan in PH. Methods The study included 32 treatment-naive patients with precapillary PH and 55 controls. All subjects underwent RHC. Total RNA was isolated and cDNAs for mRNA and miR were synthesized. mRNA expressions of HIF-1α, HIF-2α, STAT 3, FGF-2, FGFR-1, PARP 1 and miR expressions of miR-210, miR-130a, miR-424, miR-204, and miR-223 were determined. Concentrations of kynurenine, apelin, and endocan were analyzed. Results HIF-2α, STAT 3, and FGF-2 were increased; miR-210 and miR-130a were increased; miR-223 and miR-204 were decreased. Apelin and kynurenine concentrations were decreased. There were positive correlations: HIF-2α-miR-424: r=0.474, p=0.011; APLN-miR-424: r=0.385, p=0.030; kynurenine-miR-210: r=0.551, p=0.004; STAT 3- PVR: r=0.478, p=0.006; miR-210- RAP: r=0.536, p=0.07; kynurenine-RAP: r=0.409, p=0.022. There were negative correlations: PARP 1-miR-210: r=−0.561, p=0.007; PARP 1- RAP: r=−0.424, p=0.27. miR-130a (OR= 1.257, p=0.016) and APLN (OR= 0.223, p=0.004) were independent risk factors for PH. Conclusions We report: 1) novel relationship between the kynurenine and PARP 1 signaling pathways that could be mediated by miR-210, 2) relationship between the apelin and HIF-2α signaling pathways that could be mediated by miR-424, 3) reduced levels of apelin and elevated levels of miR-130a are associated with PH, 4) elevated levels of STAT 3, miR-210, and kynurenine, and reduced levels of PARP 1 correlate with more severe hemodynamics. Funding Acknowledgement Type of funding source: Other. Main funding source(s): Pamukkale University Scientific Research Projects Coordination Unit

Heavy metal adsorption using structurally preorganized adsorbent

The adsorbent had two types of functional groups and six binding sites in one coordination unit. The presence of the amide group shows good anti-interference to alkali metals and alkali soil metals.

Structure, magnetic anisotropy and relaxation behavior of seven-coordinate Co(ii) single-ion magnets perturbed by counter-anions

A series of mononuclear seven-coordinate complexes with the same coordination unit [Co(BPA-TPA)]2+ (BPA-TPA = pentapyidyldiamine) display the different slow magnetic relaxation processes perturbed by the variation of the counter anions.

A avaliação institucional em uma coordenadoria regional de educação

<p>O artigo é um recorte de pesquisa e analisa o processo da avaliação institucional em uma Coordenadoria Regional de Educação, buscando identificar a ocorrência, ou não, de mudanças durante e após a realização da avaliação diagnóstica instituída pelo Sistema Estadual de Avaliação Participativa, para a rede estadual de ensino gaúcha. As análises tiveram como fontes o banco de dados do sistema on-line da avaliação institucional, observação em formações realizadas para a implementação da política e entrevista com responsáveis pela elaboração do diagnóstico. Pode-se afirmar que, na instância analisada, os objetivos do sistema de avaliação e a dinâmica prevista para sua realização foram observados e mantidos, gerando conhecimentos e aprendizagens com potencial para qualificar as práticas institucionais.</p><p>Avaliação Institucional, Coordenadoria Regional de Educação, Participação, Sistema Estadual de Avaliação Participativa.</p><p> </p><p>La evaluación institucional en uma coordinadora regional de educación</p><p>El artículo es un recorte de investigación y analiza el proceso de evaluación institucional en una Coordinadora Regional de Educación, buscando identificar la ocurrencia - o no -, de cambios durante y después de realizarse la evaluación diagnóstica instituida por el Sistema Estadual de Evaluación Participativa, para la red estadual de enseñanza del estado de Rio Grande do Sul. Las fuentes de los análisis fueron el banco de datos del sistema on-line de la evaluación institucional, observación en formaciones realizadas para implementar la política y entrevista con los responsables por la elaboración del diagnóstico. Se puede afirmar que, en la instancia analizada, los objetivos del sistema de evaluación y la dinámica prevista para su realización se observaron y mantuvieron, generando conocimientos y aprendizajes con potencial para cualificar las prácticas institucionales.</p><p>Evaluación Institucional, Coordinadora Regional de Educación, Participación, Sistema Estadual de Evaluación Participativa.</p><p> </p><p>Institutional assessment of a regional coordination unit of education</p><p>The article analyzes findings from a broader research on the institutional assessment process of a Regional Coordination Unit of Education. It aims to identify if changes occurred during and after the completion of the diagnostic evaluation implemented by the State System of Participatory Evaluation for the state schools of Rio Grande do Sul. The sources of analysis were the online institutional assessment database, observations during trainings for the implementation of the policy, and interviews with people responsible for preparing the diagnosis. The results have shown that the assessment system objectives, as well as the dynamics involved in its completion, were observed and maintained, generating knowledge and learning able to qualify institutional practices.</p><p>Institutional Assessment, Regional Coordination Unit of Education, Participation, State System of Participatory Evaluation.</p>