“COMPARATIVE STUDY OF EFFICACY OF TOPICAL SILICONE GELAND INTRALESIONAL TRIAMCINOLONE IN TREATMENT OF KELOID”

INTRODUCTION: Keloid is a common wound healing disorder encountered in post surgery, burn and even minor injury such as ear piercing. The greatest morbidity in treatment of keloid is its high chances of recurrence post surgery. It creates a great challenge in the management of keloid. Following any trauma and surgery, the wound healing generally takes place and is completed by 6-12 months. In some patients this process is delayed and extends beyond 1 year and the excess scar formation occurs. AIMS AND OBJECTIVES: There are different modalities for the treatment of keloid. None of these modalities provides 100% efcacy in managing lesions. Different modalities have highly varying efcacy among themselves. So the objective of this study is to compare the efcacy of Intralesional Triamcinolone and topical silicon gel in management of keloid. METHODOLOGY: Sixty patients of keloid attending the outpatient Department of Surgery, Darbhanga Medical College and Hospital, Laheriasarai; Darbhanga, Bihar, constituted the source of data for a period of 2 years from January 2019 to December 2020. This study included two different treatment regimens with 30 patients in each group. RESULTS AND ANALYSIS: the students constituted the maximum number of cases i.e 38.3 % followed by housewife 30.0% ,farmers 18.3%, labouerer 6.7%, others 6.7%. respectively. however the occupation in the prevalence of disease is not signicant (p value >0.05). In majority of patients the duration of lesion was between 1 and 2 years (65 %) followed by <1 years (23.33%). Minimum number of patients were in >2 years (11.67 %) of duration. The range of duration of lesions was 6 months to 2.5 years. SUMMARYAND CONCLUSION: The both modalities of treatment was more effective in treating smaller size and shorter duration of lesion than massive keloids. Thus keloids are more common in female , over the prestrernal region and mostly present in third decade of life. Both Intralesional Triamcinolone and Topical silicon gel are effective in treating keloid with minimal side effective. Relatively better responses was seen with using Intralesional Trimacinolone than silicon gel. But silicon gel had advantage that it can used by patient itself and lesser frequency of hospital visits for administration.

Effect of Wood Fiber on the Strength of Calcareous Sand Rapidly Seeped by Colloidal Silica

Silica nano-particles are suspended in the colloidal silica and can be induced to gradually gel after the PH value changes. Thus colloidal silica can be utilized to rapidly seep through loose calcareous sand, and the silicon gel is gradually formed to bond sand particles. However, based on observation by scanning electron microscope(SEM), there are a lot of microcracks in the silica gel, which reduces the strength of the sand-gel composite. Therefore, in order to suppress crack growth, wood fibers are dispersed in the colloidal silica which still can seep through calcareous sand. 18 silicon-gel stabilized sand samples were prepared for tri-axial tests, where the concentration of colloidal silica is 20%, and wood fiber concentrations are 0%, 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, respectively. The results show that:(1) there exists an optimum ratio of wood fiber to colloidal silica, that is, as the concentration of wood fiber increases, the strength represented by the peak value of deviator stress rises first and then falls; (2) there are opposite trends between the two strength parameters, internal friction angle and cohesion, that is, when the wood fiber concentration is 0.04%, the cohesion reaches the maximum value and the internal friction angle reaches the minimum value; (3) The photos by SEM show that, there are wood fibers on the inner wall of the crack in the silica gel, which may reduce the extent of crack propagation and contribute to the strength of stabilized sand samples.

Characterization and lymphocyte proliferation activity of an oligosaccharide degraded from Astragalus polysaccharide

An Astragalus oligosaccharide (AOS) degraded from Astragalus polysaccharide (APS) and purified by membrane dialysis and silicon gel chromatography is studied in this paper.