A Pan-Cancer Census of Dominant Tumor Immune Archetypes

SUMMARYCancers display significant heterogeneity with respect to tissue of origin, driver mutations and other features of the surrounding tissue. It is likely that persistent tumors differentially engage inherent patterns–here ‘Archetypes’–of the immune system, to both benefit from a tumor immune microenvironment (TIME) and to disengage tumor-targeting. To discover dominant immune system archetypes, the Immunoprofiler Initiative (IPI) processed 364 individual tumors across 12 cancer types using standardized protocols. Computational clustering of flow cytometry and transcriptomic data obtained from cell sub compartments uncovered archetypes that exist across indications. These Immune composition-based archetypes differentiate tumors based upon unique immune and tumor gene-expression patterns. Archetypes discovered this way also tie closely to well-established classifications of tumor biology. The IPI resource provides a template for understanding cancer immunity as a collection of dominant patterns of immune infiltration and provides a rational path forward to learn how to modulate these patterns to improve therapy.

Decarbonization Pathways of Worldwide Energy Systems – Definition and Modeling of Archetypes

This paper includes an approach to summarize energy systems of countries worldwide in energy system archetypes. These archetypes are generated by a clustering algorithm and modeled in an energy system optimization model by standardized rules. The results show that archetypes provide an opportunity to compare decarbonization pathways of different countries on a global level. Furthermore, they can be used to simplify data collection and elaborate the potential of new technologies in different energy systems. <br>

Decarbonization Pathways of Worldwide Energy Systems – Definition and Modeling of Archetypes

This paper includes an approach to summarize energy systems of countries worldwide in energy system archetypes. These archetypes are generated by a clustering algorithm and modeled in an energy system optimization model by standardized rules. The results show that archetypes provide an opportunity to compare decarbonization pathways of different countries on a global level. Furthermore, they can be used to simplify data collection and elaborate the potential of new technologies in different energy systems. <br>

The Multiple Impacts of the COVID-19: A Qualitative Perspective

The world has been highly impacted by the COVID-19 as the virus has spread to all continents &ndash; about 200 countries in total. The latest update claims about 4,000,000 confirmed cases and about 300,000 confirmed deaths owing to the COVID-19 pandemic. This probably makes the COVID-19 as the most dangerous contagious disease in the era 2000s. Apart from massive publications on this topic, there is no available qualitative analysis that describes the dynamic spreads of the COVID-19 and its impacts on healthcare and the economy. Through the system archetypes analysis, this paper explains that the dynamic spread of the COVID-19 consists of the limits to growth and the success to successful structures. The limits to growth elucidates that more symptomatic and asymptomatic patients owing to infected droplets may be bounded by self-healing and isolated treatments. The success to successful structure explains that once the COVID-19 affects the economy through the lockdown, there will be a limited fund to support the government aids and the aggregate demand. In overall, this paper gives readers simplified holistic insights into understanding the dynamic spread of the COVID-19.

A 10-Year Radar-Based Climatology of Mesoscale Convective System Archetypes and Derechos in Poland

In this study, a 10-yr (2008–17) radar-based mesoscale convective system (MCS) and derecho climatology for Poland is presented. This is one of the first attempts of a European country to investigate morphological and precipitation archetypes of MCSs as prior studies were mostly based on satellite data. Despite its ubiquity and significance for society, economy, agriculture, and water availability, little is known about the climatological aspects of MCSs over central Europe. Our results indicate that MCSs are not rare in Poland as an annual mean of 77 MCSs and 49 days with MCS can be depicted for Poland. Their lifetime ranges typically from 3 to 6 h, with initiation time around the afternoon hours (1200–1400 UTC) and dissipation stage in the evening (1900–2000 UTC). The most frequent morphological type of MCSs is a broken line (58% of cases), then areal/cluster (25%), and then quasi-linear convective systems (QLCS; 17%), which are usually associated with a bow echo (72% of QLCS). QLCS are the feature with the longest life cycle. Among precipitation archetypes of linear MCSs, trailing stratiform (73%) and parallel stratiform (25%) are the most common. MCSs are usually observed from April to September, with a peak in mid-July. A majority of MCSs travels from the west, southwest, and south sectors. A total of 16 derecho events were identified (1.5% of all MCS and 9.1% of all QLCS); the majority of them were produced by a warm-season QLCS, whereas only 4 were produced by cold-season narrow cold-frontal rainbands. Warm-season derechos produced a bigger impact than did cold-season events, even though their damage paths were shorter.

New and renewable energy resources in the Indonesian electricity sector: a systems thinking approach

Purpose The purpose of this paper is to apply a systems thinking methodology to analyse Indonesia’s new and renewable energy (NRE) electricity sector to describe the complex interrelations between its actors and variables, identify the systemic patterns and formulate recommendations for the policymakers. Design/methodology/approach Systems thinking methodology is used to observe the NRE electricity system and compile the corresponding data into a meaningful diagram to describe and recommend solutions for the sector’s issues. Causal loop diagram is used as the main method in this study with a deeper analysis of system archetypes to uncover the system behaviour. Soft system methodology and critical system heuristic are used partially to clarify the system boundaries, cultivate the perspective of the involved actors and problem categorization. Findings A comprehensive diagram is developed to present interrelation between all the components within the NRE electricity sector in Indonesia and the expected impact of any act or change to the entire system. Based on the causal interrelations between variables, typical systemic patterns or archetypes are used to identify unproductive patterns towards achieving the NRE electricity sector objectives. Originality/value The findings provide an initial outlook on the variables and systemic patterns within the system as a critical consideration in the decision-making process and policy development for the NRE electricity sector.