The necessity of Integrated Medicine to treat SARS-Cov-2/ COVID-19 patient: A case report

Psychological and psychosocial issues are more prominent issues of an individual in any disease, which could further deteriorate patients’ condition and hamper their quality of life. However, in treating SARS-CoV-2/COVID-19, those patients’ mental, social, and emotional aspects are still overlooked.

COVID-19 Telephone Consultation by Iranian Traditional Medicine as an Integrative medicine: Benefits and Challenges

The COVID-19 disease started in December 2019 in Wuhan, China, and spread across the world, including the Islamic Republic of Iran. Due to the high prevalence of this disease, it resulted in worry in many people and has led to several unnecessary visits to medical centers which may have increased the risk of infection. Preventive measures are necessary to control outbreaks and decrease disease burdens. Telemedicine such as telephone consultation is an efficient and safe platform to control disease in times of infectious epidemics by reducing the communication between people and the presence of non-infected people in medical centers. Iranian traditional medicine (ITM) as integrated medicine, is a collection of scientific principles and methods for the prevention and treatment of disease. The Nobaan’s telephone consultation system was set up by ITM specialists to provide consultations for COVID-19. A total of 43 ITM physicians have been consulting health seekers every day from 6:00 a.m. to 12:00 p.m. based on national guidelines for COVID-19 and a specialized guide from academic resources of ITM. From 18 March to 17 April 2020, the doctors received a total of 2778 calls and provided a total of 11221 minutes of consultation. In total, 50% of physicians answered more than 90% of the calls and the average length of each call was 4.5 minutes. Finally, it seems except few limitations compared with face to face patient visit, this newly consultation by ITM specialist may provide considerable help to prevent and manage COVID-19 outbreak in Iran.

The Dissemination and Practice of Primary Care Medicine by the Scholar-Gentry: A Study of Prescriptions of Local Botanicals for Emergency Use, a Medical Text of Koryŏ from the Thirteenth-Fourteenth Centuries

Prescriptions of Local Botanicals for Emergency Use (K. Hyang’yak Kugŭppang 鄕藥救急方) is the oldest medical text extant on the Korean Peninsula and known to have been compiled during the latter half of the Koryŏ 高麗 dynasty (918–1392 ce). The key value of this work lies in the dissemination and praxis of medical knowledge. First, the author used annotations in order to record Koryŏ people’s pronunciations of the names of medicinal ingredients and symptoms introduced in the main body of the text. In addition, he made use of actual empirical cases to enhance the persuasiveness of treatment methods and integrated medicine newly introduced from Song 宋 China (960–1279) into medicine familiarly used from before. Finally, he edited this text with a focus on important and simple yet efficacious treatment methods. The book continued to be used steadily following publication. It was additionally printed no fewer than twice by the government of the Chosŏn 朝鮮 dynasty (1392–1910), which ousted Koryŏ, with its clinical usefulness heightened through the supplementation of explanations on medicinal ingredients use in these processes. In particular, the quotation of sentences from Prescriptions for Emergency Use in medical texts published by the Chosŏn government implies that the utility of the medical knowledge in this work was amply acknowledged. The intended readership of the medical information in Prescriptions for Emergency Use was the not the general populace who lived in the Korean Peninsula in the thirteenth-fourteenth centuries. They not only lacked the financial means to pay physicians but also were illiterate, so that they could not even read medical texts. In order for this work to be effective, it was necessary for it to address those who could read medical texts and put their contents into practice. In the end, the author of this book assumed scholar-gentry equipped with academic knowledge as its readers and sought to provide medical information tailored to their level and to realize medical service through them. Through this work, it is possible to see in a very concrete and vivid manner how medical knowledge was disseminated and, furthermore, how medical knowledge thus disseminated was put to use in an era when medical resources were insufficient.

Integrated Medicine for Chemotherapy-Induced Peripheral Neuropathy

Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of typical chemotherapeutics among cancer survivors. Despite the recent progress, the effective prevention and treatment strategies for CIPN remain limited. Better understanding of the pathogenesis of CIPN may provide new niches for developing a new ideal therapeutic strategy. This review summarizes the current understanding of CIPN and current recommendations along with completed/active clinical trials and aims to foster translational research to improve the development of effective strategies for managing CIPN.

Efficacy of Integrated Traditional Chinese and Western Medicine for Treating COVID-19: A Systematic Review and Meta-Analysis of RCTs

Background: Integrated Chinese and Western medicine (integrated medicine) is routinely used in the treatment of coronavirus disease 2019 (COVID-19) in China. In this study, we undertook a systematic review and meta-analysis of published randomized controlled trials (RCTs) to evaluate the efficacy of integrated medicine therapy for patients with COVID-19.Methods: In this meta-analysis, we searched PubMed, Embase, Web of Science, SinoMed, China National Knowledge Infrastructure (CNKI), Chongqing VIP (CQVIP), and Wanfang databases from inception to April 12, 2021, to identify RCTs of integrated medicine in the treatment of COVID-19. The quality of RCTs was assessed by the Cochrane risk of bias tool. RevMan v5.3 and Stata software packages were used for statistical analysis.Results: Nineteen RCTs involving 1,853 patients met our inclusion criteria. Compared with patients treated by conventional Western medicine (CWM), patients treated by integrated medicine have a higher overall effective rate [RR = 1.17, 95% CI: (1.10, 1.26), p < 0.00001], fever disappearance rate [RR = 1.25, 95% CI: (1.04, 1.50), p = 0.02], fatigue disappearance rate [RR = 1.28, 95% CI: (1.00, 1.63), p = 0.05], and chest CT improvement rate [RR = 1.24, 95% CI: (1.14, 1.34), p < 00001]. Beneficial effects of the integrated medicine therapy were also seen in C-reactive protein (CRP) level [WMD = −4.14, 95% CI: (−6.38, −1.91), p = 0.0003] and white blood cell (WBC) count [WMD = 0.35, 95% CI: (0.11, 0.58), p = 0.004]. Subgroup analyses showed that, when the treatment time is <2 weeks, the effect of integrated medicine treatment is more obvious in improving the overall effective rate, clinical symptoms (fever, fatigue, and cough), the CRP level, and WBC count compared with that of the CWM treatment. For patients with severe and non-severe COVID-19, integrated medicine is more effective in improving fever and cough symptoms and WBC count than using CWM alone.Conclusion: The results of the current meta-analysis suggested that the integrated medicine can improve the clinical symptoms, chest CT and infection indicators of COVID-19 patients. Even if the treatment time is <2 weeks, the effect of integrated medicine in improving symptoms is more obvious compared with the treatment of CWM. However, the results should be interpreted cautiously due to the heterogeneity among the studies.