scholarly journals Integrated Medicine for Chemotherapy-Induced Peripheral Neuropathy

2021 ◽  
Vol 22 (17) ◽  
pp. 9257
Author(s):  
Chih-Hung Tsai ◽  
Yuan-Ho Lin ◽  
Yung-Sheng Li ◽  
Trung-Loc Ho ◽  
Le Huynh Hoai Thuong ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Peripheral Neuropathy ◽  
Recent Progress ◽  
Therapeutic Strategy ◽  
Treatment Strategies ◽  
Common Side Effect ◽  
Integrated Medicine ◽  
Effective Prevention ◽  
Effective Strategies ◽  
Prevention And Treatment

Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of typical chemotherapeutics among cancer survivors. Despite the recent progress, the effective prevention and treatment strategies for CIPN remain limited. Better understanding of the pathogenesis of CIPN may provide new niches for developing a new ideal therapeutic strategy. This review summarizes the current understanding of CIPN and current recommendations along with completed/active clinical trials and aims to foster translational research to improve the development of effective strategies for managing CIPN.

scholarly journals A review of potential pharmacological treatments of COVID-19: an evidence-based perspective

2020 ◽  
Vol 9 (11) ◽  
pp. 1757
Author(s):  
Vikas Kumar ◽  
Gyan Vardhan ◽  
Kalpana Tiwari ◽  
Puneet Dhamija
Keyword(s):  
Clinical Trials ◽  
Treatment Strategies ◽  
Treatment Protocols ◽  
Effective Prevention ◽  
Safety Issues ◽  
Therapeutic Drugs ◽  
Drug Actions ◽  
Drug Regimens ◽  
Repurposed Drugs ◽  
Tract Infections

Coronaviruses (CoVs) typically manifest as mild to severe respiratory tract infections. No drug is approved by US food and drug administration (FDA) for the treatment of patients with coronaviruses infection. With growing COVID-19 pandemic globally, need of hour is to work on potential prophylactic and therapeutic drugs to prevent local and community transmission. A literature search for eligible studies published till March 2020 was conducted in the PubMed, Medline, EMBASE, OVID, and Google Scholar databases by two reviewers. Therapeutic efficacy and safety of different drug regimens targeting treatment pathway acting against corona virus-2019 (COVID-19) were reviewed. Possible mechanism of actions of these potential repurposed drugs against COVID-19 were reviewed to develop effective prevention and treatment strategies. Many potential pharmacological therapies are being studied in various clinical trials. No FDA-approved repurposed drugs have shown safety and efficacy in randomized controlled trials for patients with COVID-19. Vaccines are under development and only few vaccines are under clinical evaluation. This review highlights potential drug actions against COVID-19 and their safety issues. It could help researchers and physicians to use these potential agents judiciously in clinical trials as well as in treatment protocols.

scholarly journals Analysis SARS-CoV-2 Genomes of G20 Areas on Phylogeny Tree, t-SNE based on Machine Learning

2020 ◽  
Author(s):  
Renyang Liu ◽  
Mu Qiao ◽  
Alima ◽  
Jeffrey Zheng ◽  
Wei Zhou
Keyword(s):  
Public Health ◽  
Machine Learning ◽  
Phylogenetic Tree ◽  
Treatment Strategies ◽  
Gene Sequences ◽  
Effective Prevention ◽  
Multiple Resources ◽  
The World ◽  
Prevention And Treatment ◽  
Epidemiological Characteristics

Abstract The new coronavirus disease (COVID-19) broke out earlier in Wuhan, and the plague spread rapidly from multiple resources of different countries. COVID-19 has caused millions of diagnosed people worldwide, causing many deaths and posing a severe threat to public health in countries around the world. Facing this urgent situation, in-depth research on the emerging SARS-CoV-2 to understand the related pathogenic mechanism and epidemiological characteristics is urgent. This type of activity would be useful to determine its origin to formulate effective prevention and treatment strategies for affected patients.This paper adopts t-SNE based on machine learning to draw a phylogenetic tree from collected genomic sequences to analyze G20 countries’ samples. The phylogenetic tree of the generating mechanism was described, and intermediate results were illustrated. The results of this research showed that viruses in many countries have similar or similar relationships among the gene sequences.

scholarly journals CRISPR to the Rescue: Advances in Gene Editing for the FMR1 Gene

2019 ◽  
Vol 9 (1) ◽  
pp. 17 ◽  
Author(s):  
Carolyn Yrigollen ◽  
Beverly Davidson
Keyword(s):  
Clinical Trials ◽  
Fragile X Syndrome ◽  
Gene Editing ◽  
Therapeutic Strategy ◽  
Therapeutic Potential ◽  
Fragile X ◽  
Genetic Disorders ◽  
Treatment Strategies ◽  
Gene Pathway ◽  
Ataxia Syndrome

Gene-editing using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) is promising as a potential therapeutic strategy for many genetic disorders. CRISPR-based therapies are already being assessed in clinical trials, and evaluation of this technology in Fragile X syndrome has been performed by a number of groups. The findings from these studies and the advancement of CRISPR-based technologies are insightful as the field continues towards treatments and cures of Fragile X-Associated Disorders (FXADs). In this review, we summarize reports using CRISPR-editing strategies to target Fragile X syndrome (FXS) molecular dysregulation, and highlight how differences in FXS and Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) might alter treatment strategies for each syndrome. We discuss the various modifications and evolutions of the CRISPR toolkit that expand its therapeutic potential, and other considerations for moving these strategies from bench to bedside. The rapidly growing field of CRISPR therapeutics is providing a myriad of approaches to target a gene, pathway, or transcript for modification. As cures for FXADs have remained elusive, CRISPR opens new avenues to pursue.

Lactoferrin ameliorates pathological cardiac hypertrophy related to mitochondrial quality control in aged mice

2021 ◽  
Author(s):  
Lishan Huang ◽  
Ruiyu Chen ◽  
Libin Liu ◽  
Yu Zhou ◽  
Zhou Chen
Keyword(s):  
Quality Control ◽  
Cardiovascular Diseases ◽  
Cardiac Hypertrophy ◽  
Myocardial Hypertrophy ◽  
Treatment Strategies ◽  
The Elderly ◽  
Mitochondrial Quality Control ◽  
Effective Prevention ◽  
Pathological Cardiac Hypertrophy ◽  
Prevention And Treatment

Pathological myocardial hypertrophy, which lacks effective prevention and treatment strategies, makes the elderly susceptible to various cardiovascular diseases. Based on the beneficial attributes of lactoferrin in aging-related diseases, we aimed...

scholarly journals Neuroprotection in Stroke: Past, Present, and Future

2014 ◽  
Vol 2014 ◽  
pp. 1-17 ◽  
Author(s):  
Arshad Majid
Keyword(s):  
Clinical Trials ◽  
Brain Tissue ◽  
Recent Progress ◽  
Medical Condition ◽  
Treatment Strategies ◽  
Novel Therapies ◽  
Neuroprotective Agents ◽  
Key Points ◽  
Serious Injury ◽  
The Brain

Stroke is a devastating medical condition, killing millions of people each year and causing serious injury to many more. Despite advances in treatment, there is still little that can be done to prevent stroke-related brain damage. The concept of neuroprotection is a source of considerable interest in the search for novel therapies that have the potential to preserve brain tissue and improve overall outcome. Key points of intervention have been identified in many of the processes that are the source of damage to the brain after stroke, and numerous treatment strategies designed to exploit them have been developed. In this review, potential targets of neuroprotection in stroke are discussed, as well as the various treatments that have been targeted against them. In addition, a summary of recent progress in clinical trials of neuroprotective agents in stroke is provided.

scholarly journals Natural Supplements for COVID19—Background, Rationale, and Clinical Trials

2021 ◽  
Vol 26 ◽  
pp. 2515690X2110368
Author(s):  
Melody Hermel ◽  
Megan Sweeney ◽  
Yu-Ming Ni ◽  
Robert Bonakdar ◽  
Douglas Triffon ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Potential Benefit ◽  
Viral Infections ◽  
Scientific Evidence ◽  
Biomedical Literature ◽  
Treatment Modalities ◽  
Controversial Issues ◽  
Effective Prevention ◽  
Prevention And Treatment ◽  
Current Guidelines

Worldwide, the turmoil of the SARS-CoV-2 (COVID-19) pandemic has generated a burst of research efforts in search of effective prevention and treatment modalities. Current recommendations on natural supplements arise from mostly anecdotal evidence in other viral infections and expert opinion, and many clinical trials are ongoing. Here the authors review the evidence and rationale for the use of natural supplements for prevention and treatment of COVID-19, including those with potential benefit and those with potential harms. Specifically, the authors review probiotics, dietary patterns, micronutrients, antioxidants, polyphenols, melatonin, and cannabinoids. Authors critically evaluated and summarized the biomedical literature published in peer-reviewed journals, preprint servers, and current guidelines recommended by expert scientific governing bodies. Ongoing and future trials registered on clinicaltrials.gov were also recorded, appraised, and considered in conjunction with the literature findings. In light of the controversial issues surrounding the manufacturing and marketing of natural supplements and limited scientific evidence available, the authors assessed the available data and present this review to equip clinicians with the necessary information regarding the evidence for and potential harms of usage to promote open discussions with patients who are considering dietary supplements to prevent and treat COVID-19.

scholarly journals Analysis SARS-CoV-2 Genomes of G20 Areas on Phylogeny Tree, t-SNE based on Machine Learning

2021 ◽  
Author(s):  
Renyang Liu ◽  
Mu Qiao ◽  
Alima ◽  
Jeffrey Zheng ◽  
Wei Zhou
Keyword(s):  
Public Health ◽  
Machine Learning ◽  
Phylogenetic Tree ◽  
Treatment Strategies ◽  
Gene Sequences ◽  
Effective Prevention ◽  
Multiple Resources ◽  
The World ◽  
Prevention And Treatment ◽  
Epidemiological Characteristics

Abstract The new coronavirus disease (COVID-19) broke out earlier in Wuhan, and the plague spread rapidly from multiple resources of different countries. COVID-19 has caused millions of diagnosed people worldwide, causing many deaths and posing a severe threat to public health in countries around the world. Facing this urgent situation, in-depth research on the emerging SARS-CoV-2 to understand the related pathogenic mechanism and epidemiological characteristics is urgent. This type of activity would be useful to determine its origin to formulate effective prevention and treatment strategies for affected patients.This paper adopts t-SNE based on machine learning to draw a phylogenetic tree from collected genomic sequences to analyze G20 countries’ samples. The phylogenetic tree of the generating mechanism was described, and intermediate results were illustrated. The results of this research showed that viruses in many countries have similar or similar relationships among the gene sequences.

Assessment of dysgeusia and taste identification in patients undergoing chemotherapy for breast cancer.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e21668-e21668
Author(s):  
Sayaka Kuba ◽  
Rie Fujiyama ◽  
Kosho Yamanouchi ◽  
Chika Sakimura ◽  
Toshiko Hatachi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oral Cavity ◽  
Side Effect ◽  
Cranial Nerve ◽  
Common Side Effect ◽  
Normal Range ◽  
Effective Prevention ◽  
Basic Taste ◽  
Significant Difference ◽  
Prevention And Treatment

e21668 Background: Dysgeusia is a common side effect of chemotherapy (CT) and often impacts negatively on QOL. This study analyzed the prevalence of gustatory test abnormalities in breast cancer (BC) patients undergoing CT. Methods: We enrolled 33 BC patients who were undergoing CT (26 adjuvant CT and 7 CT for advanced BC) and conducted 2 gustatory tests on CT day. In the test of sensitivity using the instillation method (IM), 4 basic taste stimuli (sweet, salty, sour, and bitter) at 5 concentrations were applied to the entire oral cavity. For the electrogustometry method (EM), we measured the amount of current for perception of metallic tastes, examining the front two thirds of the tongue (cranial nerve VII) and the back third of the tongue (cranial nerve IX). We compared awareness of dysgeusia with results of the 2 gustatory tests. Results: Median CT duration was 83 days (12–1,353). Fifteen (45%) patients had awareness of dysgeusia (Grade 1: 11, Grade 2: 4). IM revealed 8 (24%) patients with abnormalities, 7 in a single taste species and 1 in 3 taste species. EM revealed 20 (61%) patients withabnormalities, 7 in the cranial nerve VII and 20 in the cranial nerve IX innervation area. All patients with abnormalities in the cranial nerve VII innervation area also had abnormalities in the cranial nerve IX innervation area. Among 15 patients with awareness of dysgeusia, there were 5 (33%) IM abnormalities and 12 (80%) EM abnormalities (4 in the cranial nerve VII and 12 in the cranial nerve IX innervation area). Among 18 patients without awareness of dysgeusia, there were 3 (16%) IM abnormalities and 8 (44%) EM abnormalities (3 in the cranial nerve VII and 8 in the cranial nerve IX nerve innervation area). Patients with IM abnormalities had a higher frequency of abnormalities in the cranial nerve VII innervation area than the normal range (50% and 12%, respectively; p = 0.04); there was no significant difference in the cranial nerve IX innervation area. Conclusions: Nearly half of the patients reporteddysgeusia, but most of these could correctly identify the four basic tastes. Further studies to clarify the discrepancy between subjective and objective observations could lead to effective prevention and treatment of dysgeusia.

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