A groundbreaking set of potent ideas, concepts, and methodological tools—developed over years of research and advocacy—are discussed in this chapter. The chapter provides an integral in-depth analysis of health paradigms, explaining the conceptual and technical limitations of conventional epidemiology and public health. It describes and illustrates the main theoretical and methodological ruptures and new categories needed to go beyond the Cartesian logic and its knowledge illusions. It analyzes five central breaks with the cognitive pillars of empirical epidemiology: lineal causality, external conjunction, empirical quantitative and qualitative analysis, empirical socio-epidemiological stratification, and Cartesian health geography. Examples are provided to facilitate useful reflections about research, postgraduate teaching, and health agency. The chapter also highlights some key elements for working toward a new framework for practice and ethos—one necessary to transform the notions of health prevention and promotion, to move beyond conventional conceptions, to leave our institutional comfort zones, and to reaffirm a critical scientific philosophy and rescue potent concepts of the wisdom of ‘others,” moving from passive vertical bureaucratic surveillance to active, community-based critical health monitoring.