A Phylodynamic Workflow to Rapidly Gain Insights into the Dispersal History and Dynamics of SARS-CoV-2 Lineages

Since the start of the COVID-19 pandemic, an unprecedented number of genomic sequences of SARS-CoV-2 have been generated and shared with the scientific community. The unparalleled volume of available genetic data presents a unique opportunity to gain real-time insights into the virus transmission during the pandemic, but also a daunting computational hurdle if analyzed with gold-standard phylogeographic approaches. To tackle this practical limitation, we here describe and apply a rapid analytical pipeline to analyze the spatiotemporal dispersal history and dynamics of SARS-CoV-2 lineages. As a proof of concept, we focus on the Belgian epidemic, which has had one of the highest spatial densities of available SARS-CoV-2 genomes. Our pipeline has the potential to be quickly applied to other countries or regions, with key benefits in complementing epidemiological analyses in assessing the impact of intervention measures or their progressive easement.

The Advancement of Altruism as a Criterion of Moral Validity

Jürgen Habermas’s discourse ethics is a method of intersubjective argumentation conceived to test the validity of moral norms on the basis of their universalizability. As some scholars have argued, Habermas’s proposal is problematic in that the process of argumentation is always affected by the circumstances of inequality and unfairness that pervade communal life and, therefore, it cannot be as inclusive and egalitarian as it needs to be in order to function effectively. In this paper, I argue that the solutions proposed by these scholars, namely, the improvement of social conditions and the pluralization of the process of argumentation, cannot by themselves resolve the practical limitation Habermas’s method presents. As an alternative, I adopt Philip Kitcher’s approach to ethics according to which the establishment of moral norms is oriented not to the resolution of disagreements but to the restitution of healthy relationships among individuals. On the basis of this alternative conception, I propose the addition to Habermas’s principle of universalization of a supplemental criterion of moral justification—one that makes the validity of norms dependent upon their potential to foster altruism.

Laser-range-finder localization based fuzzy control for mobile robots

Purpose Based on laser-range-finder (LRF) sensing, the control design of location and orientation stabilization for the mobile robot is investigated. However, the practical limitation of the LRF sensing is usually ignored in the control design, which leads to incorrect localization and unexpected control results. The purpose of this study is to design the fuzzy controller subject to the practical limitation on the LRF-based localization for a differentially driven wheeled mobile robot. Design/methodology/approach First, the Takagi–Sugeno (T-S) fuzzy model is derived from the polar kinematic model of a differentially driven mobile robot. Then, the fuzzy controller is designed to the derived T-S fuzzy kinematic model in accordance with the Lyapunov stabilization theorem. The derived Lyapunov stabilization conditions for the fuzzy control design are expressed as the linear matrix inequality (LMI) form and effectively solved by LMI tools. The practical limitation on the LRF-based localization is also expressed as the LMI form and simultaneously solved with the control design. Finding The location and posture stabilization experiments are carried out on a mobile robot with LRF-based localization to prove the effectiveness of the proposed T-S fuzzy model-based control design. Furthermore, the ground truth experiment evaluates the accuracy of LRF-based localization. Originality/value The contribution of this study is to develop the fuzzy control law for a differentially driven wheeled mobile robot under the practical limitation on LRF-based localization. The proposed control design can be applied to other robots with practical limitations on the sensors.

Study of Relationship of Release Parameters and Practical Influential Factors in Mechanics Models of the Distance of Shot Putting

It is a controversial topic that the reference relationship between ideal distance of the shot putting and practical training. This paper analyzes the optimal release angle and its practical limitation of ideal model, by principles of mechanics, building mathematical model by deduce of mathematics and physics and according to the practical features of Kinesiology. The results demonstrate, the optimal release angle can only act as the quantitative index for teaching and training, not the optimal results of training and competition. During the teaching and training, according to the reality, relating to self-feature of athletes, use the reasonable parameters, so as to benefit for technology and training in order to improve the grades of athletes.