scholarly journals A Phylodynamic Workflow to Rapidly Gain Insights into the Dispersal History and Dynamics of SARS-CoV-2 Lineages

2020 ◽  
Author(s):  
Simon Dellicour ◽  
Keith Durkin ◽  
Samuel L Hong ◽  
Bert Vanmechelen ◽  
Joan Martí-Carreras ◽  
...  
Keyword(s):  
Real Time ◽  
Gold Standard ◽  
Scientific Community ◽  
Virus Transmission ◽  
Genetic Data ◽  
Genomic Sequences ◽  
Proof Of Concept ◽  
Practical Limitation ◽  
Intervention Measures ◽  
The Impact

Abstract Since the start of the COVID-19 pandemic, an unprecedented number of genomic sequences of SARS-CoV-2 have been generated and shared with the scientific community. The unparalleled volume of available genetic data presents a unique opportunity to gain real-time insights into the virus transmission during the pandemic, but also a daunting computational hurdle if analyzed with gold-standard phylogeographic approaches. To tackle this practical limitation, we here describe and apply a rapid analytical pipeline to analyze the spatiotemporal dispersal history and dynamics of SARS-CoV-2 lineages. As a proof of concept, we focus on the Belgian epidemic, which has had one of the highest spatial densities of available SARS-CoV-2 genomes. Our pipeline has the potential to be quickly applied to other countries or regions, with key benefits in complementing epidemiological analyses in assessing the impact of intervention measures or their progressive easement.

scholarly journals A phylodynamic workflow to rapidly gain insights into the dispersal history and dynamics of SARS-CoV-2 lineages

2020 ◽  
Author(s):  
Simon Dellicour ◽  
Keith Durkin ◽  
Samuel L. Hong ◽  
Bert Vanmechelen ◽  
Joan Martí-Carreras ◽  
...  
Keyword(s):  
Virus Transmission ◽  
Global Scale ◽  
Spatial Density ◽  
Spatially Explicit ◽  
Long Distance ◽  
Intervention Measures ◽  
Dispersal Velocity ◽  
Dispersal Events ◽  
The Impact ◽  
Multiple Transmission

Since the start of the COVID-19 pandemic, an unprecedented number of genomic sequences of the causative virus (SARS-CoV-2) have been generated and shared with the scientific community. The unparalleled volume of available genetic data presents a unique opportunity to gain real-time insights into the virus transmission during the pandemic, but also a daunting computational hurdle if analysed with gold-standard phylogeographic approaches. We here describe and apply an analytical pipeline that is a compromise between fast and rigorous analytical steps. As a proof of concept, we focus on the Belgium epidemic, with one of the highest spatial density of available SARS-CoV-2 genomes. At the global scale, our analyses confirm the importance of external introduction events in establishing multiple transmission chains in the country. At the country scale, our spatially-explicit phylogeographic analyses highlight that the national lockdown had a relatively low impact on both the lineage dispersal velocity and the long-distance dispersal events within Belgium. Our pipeline has the potential to be quickly applied to other countries or regions, with key benefits in complementing epidemiological analyses in assessing the impact of intervention measures or their progressive easement.

scholarly journals COVID-19 Spread in India: Dynamics, Modeling, and Future Projections

2020 ◽  
Author(s):  
Rajesh Ranjan
Keyword(s):  
Regional Analysis ◽  
Virus Transmission ◽  
Reliable Estimate ◽  
Dynamics Modeling ◽  
Future Projections ◽  
Intervention Measures ◽  
True Number ◽  
Geographical Regions ◽  
Large Virus ◽  
The Impact

AbstractCOVID-19 is an extremely infectious disease with a relatively large virus incubation period in the affected people who may be asymptomatic. Therefore, to reduce the transmission of this pathogen, several countries have taken many intervention measures. In this paper, we show that the impact of these measures in India is different from several other countries. It is shown that an early lockdown in late March 2020 changed the initial exponential growth curve of COVID-19 to a linear one, but a surge in the number of cases from late April 2020 brought India back to a quadratic trajectory. A regional analysis shows the disparate impact of the intervention in different states. It is further shown that the number of reported infections correlates with the number of tests, and therefore regions with limited diagnostics resources may not have a realistic estimate of the virus spread. This insufficiency of diagnostic test data is also reflected in an increasing positivity rate for India nearly 2.5 months after the lockdown, inconsistent with the trends observed for other geographical regions. Nonetheless, future projections are made using different epidemiological models based on the available data, and a comparative study is presented. In the absence of a reliable estimate of the true number of infections, these projections will have a limited accuracy: with that limitation, the most optimistic prediction suggests a continuing virus transmission through September 2020.

scholarly journals On the review of electronic technologies applied to implantable medical devices

2021 ◽  
Author(s):  
Ronny García-Ramírez ◽  
Gabriel Madrigal-Boza ◽  
Edgar Solera-Bolaños ◽  
Muhammad Ali Siddiqi ◽  
Christos Strydis ◽  
...  
Keyword(s):  
Medical Devices ◽  
Scientific Community ◽  
Heterogeneous Systems ◽  
Point Of View ◽  
Proof Of Concept ◽  
Implantable Medical Devices ◽  
Heart Arrhythmia ◽  
Sql Database ◽  
The Impact ◽  
Electronic Technologies

The development of electronic implantable medical devices (IMD) has been increasing over the years, targeting very diverse applications and implementing different technologies. The impact of IMDs in the treatment of different ailments like Parkinson’s disease, hearing impairment, heart arrhythmia, and chronic pain, among many others, has been notorious and inspired their exploration to treat other health problems. Even when there is great interest in the scientific community for the exploration and development of IMDs, no standards are ruling its development. This lack of standardization is the reason why the analysis of the tendencies of this area from the technical point of view becomes complex. The analysis of the tendencies in the development of IMD devices required the exploration of diverse sources, which describe heterogeneous systems using very different approaches and methodologies for similar problems. In this paper an open SQL database intended for collecting information from IMD publications is presented; at this point, more than 200 published works are feed in the database covering a period from 1974 to 2018. This database is extensible and enables researchers to find trends and explore the development of IMDs from a broader perspective. We also used this database as a proof of concept to explore some general trends in the design of  IMDs based on the included works.

The impact of real-time continuous glucose monitoring on metabolic control in children with type 1 diabetes

2020 ◽  
Author(s):  
Ruxandra Calapod Ioana ◽  
Irina Bojoga ◽  
Duta Simona Gabriela ◽  
Ana-Maria Stancu ◽  
Amalia Arhire ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Real Time ◽  
Metabolic Control ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring ◽  
The Impact

THE IMPACT OF TV ADVERTISING ON VIRAL: ANALYSIS USING REAL-TIME AD RATINGS

2019 ◽  
Vol 2019 ◽  
pp. 790-791
Author(s):  
Cunhyeong Ci ◽  
◽  
Hyo-Gyoo Kim ◽  
Seungbae Park ◽  
Heebok Lee
Keyword(s):  
Real Time ◽  
Tv Advertising ◽  
The Impact

778-P: The Impact of Self-Management Blood Glucose (SMBG) Real-Time Decision Support on Glycemic Control in Adult with T1D in China

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 778-P
Author(s):  
ZIYU LIU ◽  
CHAOFAN WANG ◽  
XUEYING ZHENG ◽  
SIHUI LUO ◽  
DAIZHI YANG ◽  
...  
Keyword(s):  
Decision Support ◽  
Blood Glucose ◽  
Glycemic Control ◽  
Real Time ◽  
Self Management ◽  
The Impact

45. Education at distance: Broadcasting ECG rounds to Southeastern Ontario (BESO Project). An innovative approach for teaching electrocardiography

2007 ◽  
Vol 30 (4) ◽  
pp. 51 ◽  
Author(s):  
A. Baranchuk ◽  
G. Dagnone ◽  
P. Fowler ◽  
M. N. Harrison ◽  
L. Lisnevskaia ◽  
...  
Keyword(s):  
Health Care ◽  
Real Time ◽  
Digital Signal ◽  
Teaching Methodology ◽  
Care Providers ◽  
Long Distance ◽  
Medicine Clerkship ◽  
Time Problem ◽  
The Impact ◽  
Ecg Interpretation

Electrocardiography (ECG) interpretation is an essential skill for physicians as well as for many other health care professionals. Continuing education is necessary to maintain these skills. The process of teaching and learning ECG interpretation is complex and involves both deductive mechanisms and recognition of patterns for different clinical situations (“pattern recognition”). The successful methodologies of interactive sessions and real time problem based learning have never been evaluated with a long distance education model. To evaluate the efficacy of broadcasting ECG rounds to different hospitals in the Southeastern Ontario region; to perform qualitative research to determine the impact of this methodology in developing and maintaining skills in ECG interpretation. ECG rounds are held weekly at Kingston General Hospital and will be transmitted live to Napanee, Belleville, Oshawa, Peterborough and Brockville. The teaching methodology is based on real ECG cases. The audience is invited to analyze the ECG case and the coordinator will introduce comments to guide the case through the proper algorithm. Final interpretation will be achieved emphasizing the deductive process and the relevance of each case. An evaluation will be filled out by each participant at the end of each session. Videoconferencing works through a vast array of internet LANs, WANs, ISDN phone lines, routers, switches, firewalls and Codecs (Coder/Decoder) and bridges. A videoconference Codec takes the analog audio and video signal codes and compresses it into a digital signal and transmits that digital signal to another Codec where the signal is decompressed and retranslated back into analog video and audio. This compression and decompression allows large amounts of data to be transferred across a network at close to real time (384 kbps with 30 frames of video per second). Videoconferencing communication works on voice activation so whichever site is speaking has the floor and is seen by all the participating sites. A continuous presence mode allows each site to have the same visual and audio involvement as the host site. A bridged multipoint can connect between 8 and 12 sites simultaneously. This innovative methodology for teaching ECG will facilitate access to developing and maintaining skills in ECG interpretation for a large number of health care providers. Bertsch TF, Callas PW, Rubin A. Effectiveness of lectures attended via interactive video conferencing versus in-person in preparing third-year internal medicine clerkship students for clinical practice examinations. Teach Learn Med 2007; 19(1):4-8. Yellowlees PM, Hogarth M, Hilty DM. The importance of distributed broadband networks to academic biomedical research and education programs. Acad Psychaitry 2006;30:451-455

ON THE CLASSIFICATION OF DIGITAL TECHNOLOGIES IN CIVIL PROCESS

2019 ◽  
pp. 27-35
Author(s):  
Alexandr Neznamov
Keyword(s):  
Information Processing ◽  
Scientific Community ◽  
Digital Technologies ◽  
Significant Feature ◽  
Legal Proceedings ◽  
Civil Process ◽  
Civil Proceedings ◽  
Processing Information ◽  
The Impact

Digital technologies are no longer the future but are the present of civil proceedings. That is why any research in this direction seems to be relevant. At the same time, some of the fundamental problems remain unattended by the scientific community. One of these problems is the problem of classification of digital technologies in civil proceedings. On the basis of instrumental and genetic approaches to the understanding of digital technologies, it is concluded that their most significant feature is the ability to mediate the interaction of participants in legal proceedings with information; their differentiating feature is the function performed by a particular technology in the interaction with information. On this basis, it is proposed to distinguish the following groups of digital technologies in civil proceedings: a) technologies of recording, storing and displaying (reproducing) information, b) technologies of transferring information, c) technologies of processing information. A brief description is given to each of the groups. Presented classification could serve as a basis for a more systematic discussion of the impact of digital technologies on the essence of civil proceedings. Particularly, it is pointed out that issues of recording, storing, reproducing and transferring information are traditionally more «technological» for civil process, while issues of information processing are more conceptual.

Optimisation and control of the inflow to a wastewater treatment plant using integrated modelling tools

1998 ◽  
Vol 37 (1) ◽  
pp. 347-354 ◽  
Author(s):  
Ole Mark ◽  
Claes Hernebring ◽  
Peter Magnusson
Keyword(s):  
Wastewater Treatment ◽  
Real Time ◽  
Wastewater Treatment Plant ◽  
Treatment Plant ◽  
Pilot Project ◽  
Integrated Modelling ◽  
Real Time Control ◽  
Sewer System ◽  
Time Control ◽  
The Impact

The present paper describes the Helsingborg Pilot Project, a part of the Technology Validation Project: “Integrated Wastewater” (TVP) under the EU Innovation Programme. The objective of the Helsingborg Pilot Project is to demonstrate implementation of integrated tools for the simulation of the sewer system and the wastewater treatment plant (WWTP), both in the analyses and the operational phases. The paper deals with the programme for investigating the impact of real time control (RTC) on the performance of the sewer system and wastewater treatment plant. As the project still is in a very early phase, this paper focuses on the modelling of the transport of pollutants and the evaluation of the effect on the sediment deposition pattern from the implementation of real time control in the sewer system.

scholarly journals Power Hardware-in-the-Loop-Based Performance Analysis of Different Converter Controllers for Fast Active Power Regulation in Low-Inertia Power Systems

Energies ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 3274
Author(s):  
Jose Rueda Torres ◽  
Zameer Ahmad ◽  
Nidarshan Veera Kumar ◽  
Elyas Rakhshani ◽  
Ebrahim Adabi ◽  
...  
Keyword(s):  
Performance Evaluation ◽  
Power Systems ◽  
Real Time ◽  
Control Strategies ◽  
Active Power ◽  
Power Electronic ◽  
Hardware In The Loop ◽  
Digital Controllers ◽  
Power Regulation ◽  
The Impact

Future electrical power systems will be dominated by power electronic converters, which are deployed for the integration of renewable power plants, responsive demand, and different types of storage systems. The stability of such systems will strongly depend on the control strategies attached to the converters. In this context, laboratory-scale setups are becoming the key tools for prototyping and evaluating the performance and robustness of different converter technologies and control strategies. The performance evaluation of control strategies for dynamic frequency support using fast active power regulation (FAPR) requires the urgent development of a suitable power hardware-in-the-loop (PHIL) setup. In this paper, the most prominent emerging types of FAPR are selected and studied: droop-based FAPR, droop derivative-based FAPR, and virtual synchronous power (VSP)-based FAPR. A novel setup for PHIL-based performance evaluation of these strategies is proposed. The setup combines the advanced modeling and simulation functions of a real-time digital simulation platform (RTDS), an external programmable unit to implement the studied FAPR control strategies as digital controllers, and actual hardware. The hardware setup consists of a grid emulator to recreate the dynamic response as seen from the interface bus of the grid side converter of a power electronic-interfaced device (e.g., type-IV wind turbines), and a mockup voltage source converter (VSC, i.e., a device under test (DUT)). The DUT is virtually interfaced to one high-voltage bus of the electromagnetic transient (EMT) representation of a variant of the IEEE 9 bus test system, which has been modified to consider an operating condition with 52% of the total supply provided by wind power generation. The selected and programmed FAPR strategies are applied to the DUT, with the ultimate goal of ascertaining its feasibility and effectiveness with respect to the pure software-based EMT representation performed in real time. Particularly, the time-varying response of the active power injection by each FAPR control strategy and the impact on the instantaneous frequency excursions occurring in the frequency containment periods are analyzed. The performed tests show the degree of improvements on both the rate-of-change-of-frequency (RoCoF) and the maximum frequency excursion (e.g., nadir).

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