Selective cadmium fluorescence probe based on bis-heterocyclic molecule and its imaging in cells

Fluorescence probes that selectively image cadmium are useful for detecting and tracking the amount of Cd2+ in cells and tissues. In this study, we designed and synthesized a novel Cd2+ fluorescence probe based on the pyridine-pyrimidine structure, 4-(methylsulfanyl)-6-(pyridin-2-yl)pyrimidin-2-amine (3), as a low-molecular-weight fluorescence probe for Cd2+. Compound 3 could successfully discriminate between Cd2+ and Zn2+ and exhibited a highly selective turn-on response toward Cd2+ over biologically related metal ions. The dissociation constant and detection limit of 5.4 x 10− 6 mol L− 1 and 4.4 × 10− 7 mol L− 1, respectively, were calculated using fluorescence titration experiments. Studies with closely related analogs showed that the bis-heterocyclic moiety of 3 acted as both a coordination site for Cd2+ and a fluorophore. Further, the methylsulfanyl group of compound 3 is essential for achieving selective and sensitive Cd2+ detection. Fluorescence microscopy studies using living cells revealed that the cell membrane permeability of compound 3 is sufficient to detect intracellular Cd2+. These results indicate that novel bis-heterocyclic molecule 3 has considerable potential as a fluorescence probe for Cd2+ in biological applications.

Small Heterocyclic Molecule as Multiscale Transistor: A Quantum Many-Body Approach

Weakly coupled molecular junctions are an active and important field of research due to their non-linear charge carrier transport. Herein, we investigate transport properties in a weakly coupled molecule, B2C2N2H6,...

Chalcone Derived Pyrazole Synthesis via One-pot and Two-pot Strategies

Pyrazole is an imperative heterocyclic molecule in the synthetic and medicinal fields. Pyrazole is stable compound that is particularly used in pharmaceutical applications (i.e., anticancer, antifungal, antiviral, antimicrobial and antioxidant) and electronic industries. This review depicted the synthesis of pyrazoles derivatives by employing chalcone derivatives as a starting material via one and two-pot strategies. The one-pot strategy is an exclusive method for chalcone cyclization and oxidation, while two-pot strategy is reported through the preparation of chalcone derivatives, i.e., pyrazoline, hydrazone and bromochalcone prior to the synthesis of pyrazole. One-pot strategy is frequently reported for pyrazole synthesis purposes due to unique, stable, reactive and well-known chalcone reactants having easy handing then two-pot strategy. This review is momentous in organic chemistry, especially synthesis related to pyrazole and drug industry.

Synthesis, Characterization and DFT Analysis of Benzimidazolylpyrazolylacrylonitrile

A novel heterocyclic molecule possessing two important scaffolds such as pyrazole and benzimidazole was synthesized and the structure of the same was corroborated based on analytical and spectroscopic techniques. The molecular structure of 6 was optimized; FMO energies associated properties were calculated. The hyperpolarizability (βtot) and electric dipole moment (μtot) of 6 were computed. When compared to urea, the β was 7.6 times superior, which validate the target 6 may serve as a candidate for NLO applications.

Crystal structure of 2,5-bis(4-methylpyridin-2-yl)pyrazine chloroform disolvate

The heterocyclic molecule in the title solvate, C16H14N4·2CHCl3, possesses inversion symmetry, with the inversion centre situated at the centre of the pyrazine ring. The outer pyridine rings are inclined to the central pyrazine ring by 4.89 (9)°. The compound crystallized as a chloroform disolvate with the solvent molecules linked to the title molecule by C—H...N hydrogen bonds. In the crystal, molecules are further linked by π–π interactions involving the pyrazine and pyridine rings of neighbouring molecules [inter-centroid distance = 3.5629 (12) Å; symmetry code:x,y + 1,z + 1].