scholarly journals Frequency of endemic goiter and indicators of pituitary-thyroid profile in Arctic children

2021 ◽  
Vol 38 (4) ◽  
pp. 18-24
Author(s):  
S. A. Evseeva ◽  
T. E. Burtseva ◽  
T. M. Klimova ◽  
N. A. Danilov ◽  
V. G. Chasnyk ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Children And Adolescents ◽  
Preventive Measures ◽  
Endemic Goiter ◽  
Thyroid Stimulating Hormone ◽  
Free Thyroxine ◽  
The Arctic ◽  
Population Groups ◽  
Arctic Regions ◽  
Thyroid Profile

Objective. Analysis of the frequency of endemic goiter and indicators of the pituitary-thyroid profile in children aged 10-18 years living in the Arctic regions of Yakutia. Materials and methods. The study was conducted among children and adolescents of the Arctic regions of Yakutia (Bulunsky, Anabarsky, Allaikhovsky, Nizhnekolymsky, Verkhnekolymsky district) during field medical expeditions in 20182020. A total of 392 children aged 1018 years were examined. Results. In 30 % of the examined children, an increase in the thyroid gland was observed, which was accompanied by elevated levels of free thyroxine. In 3 % of children, an increase in the level of thyroid-stimulating hormone was detected against the background of reduced or normal levels of free thyroxine. Conclusions. As for the prevalence of cases of endemic goiter, the Arctic regions of Yakutia are the areas of severe goiter endemia. The results obtained justify the need for additional scientific studies to assess the degree of iodine availability (by the concentration of iodine in the urine) in different population groups and real implementation of the strategy of mass preventive measures.

scholarly journals A genome-wide association study of thyroid stimulating hormone and free thyroxine in Danish children and adolescents

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0174204 ◽  
Author(s):  
Tenna Ruest Haarmark Nielsen ◽  
Emil Vincent Rosenbaum Appel ◽  
Mathilde Svendstrup ◽  
Johanne Dam Ohrt ◽  
Maria Dahl ◽  
...  
Keyword(s):  
Association Study ◽  
Children And Adolescents ◽  
Genome Wide Association Study ◽  
Thyroid Stimulating Hormone ◽  
Free Thyroxine ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome ◽  
Stimulating Hormone

The Canadian Sledge Dogs of the Eastern and Western Arctic

Polar Record ◽  
1937 ◽  
Vol 2 (13) ◽  
pp. 59-68 ◽  
Author(s):  
S. Hadwen
Keyword(s):  
Preventive Measures ◽  
Good Condition ◽  
The Arctic ◽  
The North ◽  
Arctic Regions ◽  
Arctic Exploration ◽  
Western Arctic ◽  
Time Of Year ◽  
Working Out ◽  
Better Than

In reading of Arctic exploration one is struck with the ill-fate which has often beset the dogs accompanying the explorers. Recently Baashuus-Jessen (1935) has carefully studied the accounts of many of these important expeditions and, according to this author, the lack of proper food containing right amounts of fat, minerals and vitamins was the principal cause of nervous diseases and malnutrition in the animals. In the Arctic and Antarctic regions, nevertheless, some most successful journeys have been accomplished with the aid of dogs. Unfortunately, it should be added that though the explorers reached their goals, it was often at the expense of their animals. Without doubt, also, when a stage is reached where dogs have to be sacrificed to feed the living, the latter are not in much better condition than those which were killed. Personally I should like to see or hear of an expedition, to one of the Poles or to some other place difficult of access, where all the dogs would return in good condition, to show the world what could be done with proper food and management. This article has been written for the Institute in the hope that the information about sledge-dogs may be of some assistance to those about to undertake expeditions in the Arctic regions. In this connection I should like to say that no other domesticated animal can withstand the hardships of the north better than the dog. He can follow man wherever he goes, and I have wondered why he is not more used, for instance, in mountaineering at the lower levels. The dog, being a native animal, winters well if he is properly fed, and should be at his best when the days begin to lengthen, which is just the time of year long journeys are undertaken. I will conclude by hoping that some of our young men will make a study of this matter: first of all by getting a thorough understanding of the mechanical laws involved in traction and harnessing; secondly, in working out balanced rations with the food available in the different countries where the dogs are to be driven, and also by making a study of hygiene and of preventive measures against disease and parasites; and lastly, by getting some actual practice in dog driving.

scholarly journals Evaluation of thyroid profile for renal dysfunction in dairy cows

2020 ◽  
pp. 92-101
Author(s):  
N. Vovkotrub ◽  
A. Melnyk ◽  
V. Bezukh ◽  
M. Tyshkivskii
Keyword(s):  
Thyroid Gland ◽  
Functional State ◽  
Metabolic Diseases ◽  
Thyroid Stimulating Hormone ◽  
Pathological Process ◽  
Control Group ◽  
Metabolic Products ◽  
Simultaneous Decrease ◽  
Thyroid Profile ◽  
Toxic Goiter

Chronic pathological process in kidney saffect the hypothalamic-pituitary-thyroid system and peripheral metabolism of thyroid hormones. Pathological blood components, which accumulate due to intoxication of metabolic products, the uremic toxins, can affect the metabolism of T3 - and T4 -hormones. In cows on the Ukraine territory such thyroid diseases as hypothyroidism, less often hyperthyroidism, endemic and sporadic goiter, diffuse toxic goiter, tumors were detected, changes in the functional state of the thyroid gland with ketosis, osteodystrophy, hepatodystrophy, polymorbidic pathology were described. Metabolic diseases, which are based on impaired absorption of certain macro-and micronutrients, determine the functional activity of the thyroid gland. The data presented in the article indicate the develop of latent nephropathy in cows during the early milking period with the background of reduced energy supply, which was reflected in the disorders of filtration, excretory and concentration capacity of renal structures with a probable decrease the urea (p<0.001) and creatinine to 3982.4±414.4 μmol/l in urine, a decrease in the value of concentration indices – CI and FCU in 1.7 and 1.4 times, respectively, compared with animals in the control group, the development of hypostenuria with a decrease in relative urinary density to 1.022±0.004 kg/m3 (p<0,01) and selective proteinuria with a probable increase in the protein/creatinine ratio in 3.14 times compared with the cows of the control group. The disorders of the renal functional state was accompanied by changes in the thyroid profile in cows, which was characterized by a probable increase the T3 hormone level to 4.12±0.55 nmol/l (p<0.05) with a simultaneous decrease in thyroxine to 74.2±13,0 nmol/l (p<0,05) on the background of high values of TSH in blood serum (666.8±51.9 nMO/ml). Key words: nephropathy, highly productive cows, thyroid gland, thyroxine, triiodothyronine, thyroid-stimulating hormone.

Iodine deficiency diseases in children and adolescents (plenary lecture)

2019 ◽  
Vol 43 (3) ◽  
pp. 3-7 ◽  
Author(s):  
E. P. Kasatkina
Keyword(s):  
Thyroid Gland ◽  
Adverse Effects ◽  
Children And Adolescents ◽  
Human Health ◽  
Iodine Deficiency ◽  
Functional Activity ◽  
Endemic Goiter ◽  
Plenary Lecture ◽  
Long Time ◽  
Deficiency Diseases

The main consequence of iodine deficiency in the environment is the development of goiter in people living in iodine-deficient regions (endemic goiter). In this regard, for a long time it was considered that goiter is the only manifestation of this condition. It has now been proven that, in addition to goiter, iodine deficiency also has other adverse effects on human health. In 1983, the term "endemic goiter" was replaced by the term  "iodine deficiency diseases" (IDD). These diseases are caused by a decrease in the functional activity of the thyroid gland in response to iodine deficiency.

scholarly journals Clinical-laboratory and instrument indices of the thyroid gland state after surgical treatment of tumors of the chiasmatic-cellar region

2010 ◽  
Vol 9 (4) ◽  
pp. 59-62
Author(s):  
Ya. A. Kan ◽  
M. G. Zhestikova ◽  
S. M. Bryzgalina ◽  
N. P. Shakhvorost
Keyword(s):  
Surgical Treatment ◽  
Thyroid Gland ◽  
Thyroid Hormones ◽  
Operative Treatment ◽  
Autoimmune Thyroiditis ◽  
Clinical Laboratory ◽  
Thyroid Stimulating Hormone ◽  
Free Thyroxine ◽  
Secondary Hypothyroidism ◽  
Cellular Area

Hypopituitarism is often developed in the result of operative treatment of tumours in chiasmal-cellular area. One of frequent indications of hypophysis’ deficit is decreasing of product of thyroid-stimulating hormone (TSH) that leads to deficit of thyroid hormones. Most patients, who had been operated in terms of tumours of chiasmal-cellular area, have normal volume and structure of thyroid gland in the background of decreased level of free thyroxine and absence of increasing of level of TSH on the principle of feedback, it indicates to the secondary character of destruction of thyroid gland. Patients operated in terms of craniopharyngioma and somatoprolactinoma more often have secondary hypothyroidism. A high per cent of fibrotic changes of tissue of thyroid gland in patients operated in terms of prolactinoma is explain by autoimmune thyroiditis in anamnesis.

scholarly journals Acute effects on the thyroid gland after non-directed radiation therapy in children and adolescents

2013 ◽  
Vol 13 (3) ◽  
pp. 310-316 ◽  
Author(s):  
C. C. Bonato ◽  
H. B. Dias ◽  
M. da S. Alves ◽  
L. O. Duarte ◽  
T. M. Dias ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Thyroid Gland ◽  
Children And Adolescents ◽  
Thyroid Volume ◽  
Thyroid Stimulating Hormone ◽  
Planning System ◽  
Acute Injury ◽  
Follicular Epithelium ◽  
Treatment Planning System ◽  
Thyroid Peroxidase

AbstractBackgroundDuring radiation therapy, unwanted scatter to healthy tissues outside the target field may occur. Children and adolescents are more sensitive to radiation injury, and the thyroid gland is particularly susceptible to these effects.PurposeTo assess acute changes in thyroid function and volume in children and adolescents undergoing radiotherapy for a variety of non-thyroid cancers.Materials and MethodsThirty-one children and adolescents underwent radiation therapy of various body areas in which the thyroid was not included. Thyroid-stimulating hormone (TSH), thyroxine (T4), free thyroxine (fT4), triiodothyronine (T3), anti-thyroperoxidase antibodies and thyroglobulin were measured before, on the last day and at 1 and 3 months after the end of radiotherapy. Ultrasound scans were taken and 6- and 24-hour 131I uptake was measured before and after treatment. The scattered dose to the thyroid region was estimated with a treatment planning system or measured with thermoluminescent dosimeters.ResultsThe median radiation dose scattered to the thyroid was 296·6 cGy (IQR 16·7–1,709·0). Levels of TSH (p = 0·575), T4 (p = 0·950), fT4 (p = 0·510), T3 (p = 0·842), thyroglobulin (p = 0·620) and anti-thyroid peroxidase antibodies (p = 0·546) were statistically similar at all four time points. There were no differences between pre- and post-radiotherapy thyroid volume and 131I uptake (p = 0·692 and 0·92, respectively).ConclusionMore sensitive methods may be required to ascertain whether acute injury to the follicular epithelium occurs with lower radiation doses scattered to the thyroid.

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