PATHWAYS INTO A SCIENTIFIC ELITE: THE SOCIAL ORIGINS, SCHOOLING AND UNIVERSITIES OF FELLOWS OF THE ROYAL SOCIETY BORN FROM 1900

We report on continuing research on the British scientific elite, intended to illustrate a proposed new approach to elite studies, and based on prosopographical data on Fellows of the Royal Society born from 1900. We extend analyses previously reported of Fellows’ social origins and secondary schooling so as to take their university careers into account. The composite term ‘Oxbridge’ is called into question, as Cambridge appears historically to have been far more productive of members of the scientific elite than Oxford. However, Fellows from more advantaged class backgrounds do have a clearly higher probability than others of having attended Cambridge, Oxford or London, rather than universities outside of ‘the golden triangle’ – an outcome only partially mediated through private schooling. The ‘long arm’ of family of origin is thus apparent, although private schooling has been more important in helping Fellows from managerial rather than from professional families to gain entry to an elite university. Family influences on Fellows’ fields of research also remain, even though a further major factor is the universities they attended. A ‘royal road’ into the scientific elite, which Fellows from higher professional and managerial families have the highest probability of having followed, can be identified: that leading from private schooling to both undergraduate and postgraduate study at Cambridge. But the most common pathway, taken by 20% of all Fellows, is that leading from state schooling to undergraduate and graduate study at universities outside of the golden triangle. Fellows from higher professional, but not managerial, families show a distinctively high probability of having avoided this pathway; but it is that most common for Fellows of all less advantaged class origins. The case of the British scientific elite would suggest that detailed and disaggregated analyses of processes of elite formation can show these to be much more diverse than has often been supposed.

Virtual screening, pharmacokinetics, and molecular dynamics simulations studies to identify potent approved drugs for Chlamydia trachomatis treatment

Background The most frequent bacterial sexually transmitted disease is Chlamydia trachomatis (STD). In 2010, the Centers for Disease Control and Prevention (CDC) received 1.3 million reports of cases (CDC). Human chlamydial infections are linked to a variety of clinical symptoms. Inclusion (IncA) membranes are a promising drug target for the treatment of Chlamydia trachomatis. In the present study, molecular docking, ADMET, golden triangle, and molecular dynamics (MD) simulation studies were performed on a series of salicylidene acylhydrazides derivatives against Chlamydia trachomatis. Three types of docking software with different algorithms were used to screen the potential candidate against Chlamydia trachomatis. Results The results obtained from the docking analysis succeeded in screening nine novel hit compounds with high affinity to IncA membranes. Then, pharmacokinetics properties were calculated to spot out the drug-likeness of the selected compounds. Also, golden triangles were performed on the selected compounds. Compounds outside the golden triangle indicate that they would have clearance problems. Out of the nine novel hits drugs, four compounds pass the golden triangle screening and virtually all the quality assurance tests proposed by the model and were used for further analysis. One-ns molecular dynamics simulations on the docked complex of compound 44 (one of the highly active selected compounds of the dataset) aided in the further exploration of the binding interactions. Some crucial residues such as Ser111, Gln114, Asn107, Leu142, Gly144, Gln143, Lys104, Tyr149, Phe108, Phe145, and Arg146 were identified. Conventional and carbon–hydrogen bond interactions with amino residues Arg146, Asn107, Phe145, and Ser111 were critical for the binding of inclusion (IncA) membranes inhibitors. Conclusion Outcomes of the study can further be exploited to develop potent inclusion (IncA) membranes inhibitors.

Dimensions of culinary tourism and hospitability in Golden Triangle of India

"ABSTRACT. Purpose: Delhi, Agra and Jaipur form the golden triangle of India. This tourist triangle is designed to up-sell in the market with lucrative offers. “Palace on Wheels” is a luxury train that runs on this route and is targeted for foreign clientele with its extravagance segment. These three destinations have their significance due to the presence of historical monuments and UNESCO world heritage sites i.e., Qutub Minar, India Gate, Tajmahal, and many more. These places also offer an enormous variety of food and beverage with warm hospitality to relieve the tired tourists. The gourmet dishes of Golden Triangle are a must to try as it dates to the traditional cooking combined with a spicy aroma and soothing beverages. The paper is structured to judge the culinary facet and warm hospitality of the Golden Triangle. The main objective is to find out the impact of traditional food in attracting travellers. It will also identify the food trail experiences in enhancing a niche segment of buyers for culinary tourism. Design/methodology/approach: The research is exploratory and draws on food and beverage culinary experience delivery in the Golden Triangle. The exploratory research will judge the effectiveness of food tours and the warm hospitality extended to food tourists. Findings: The research will examine how Culinary Tourism and Hospitality in the Golden Triangle of India can form a niche segment of food and beverage buyers. How it enhances the customer experience with hospitable conduct. The study will highlight the benefits of culinary tourism and hospitality. Practical implications: The paper recommends the concepts of food and beverage culinary tourism experience for creating a niche segment of buyers as well as attracting potential buyers with its approach. The research will synthesize the factors to improve customer interest in taking food and beverage tourism. Originality/value: The research sought to address the advantages of curating food and beverage tourists in the golden triangle of India. It will also address how food and beverage tours can influence culinary tourism. Keywords: Culinary tourism, hospitality, traditional food, secret recipes, niche segment. JEL Classification: L83, Z31 "

PROJECT RISK MANAGEMENT BASED ON A SET OF BEST PRACTICES

The purpose of this article is to present the process of risk management in project management. The analysis was based on a comparison of two best practices of IPMA and PRINCE. Risk management differs significantly between the two approaches, but it is up to the organization to choose its own management, monitoring and methodology tailored to the specific industry or sector. Risk management is an important aspect of the entire project life cycle and must be monitored throughout the project life cycle to protect not only the budget but all areas of the so-called "golden triangle". A very important aspect is the organization's awareness that risk management is everyone's responsibility, not just the project manager. This paper presents two different approaches to project risk management in two different methodologies.

CALCITE U-Pb DATING UNRAVELS THE AGE AND HYDROTHERMAL HISTORY OF THE GIANT SHUIYINDONG CARLIN-TYPE GOLD DEPOSIT IN THE GOLDEN TRIANGLE, SOUTH CHINA

The ages of Carlin-type gold deposits in the Golden Triangle of South China have long been questioned due to the general lack of minerals unequivocally linked to gold deposition that can be precisely dated using conventional radiogenic isotope techniques. Recent advances in U-Pb methods show that calcite can be used to constrain the ages of hydrothermal processes, but few studies have been applied to ore deposits. Herein, we show that this approach can be used to constrain the timing of hydrothermal activity that generated and overprinted the giant Shuiyindong Carlin-type gold deposit in the Golden Triangle. Three stages of calcite (Cal-1, Cal-2, and Cal-3) have been recognized in this deposit based on crosscutting relationships, cathodoluminescence colors, and chemical (U, Pb, and rare earth element [REE]) and isotope (C, O, Sr) compositions. Cal-1 is texturally associated with ore-stage jasperoid and disseminated Au-bearing arsenian pyrite in hydrothermally altered carbonate rocks, which suggests it is synmineralization. Cal-2 fills open spaces and has a distinct orange cathodoluminescence, suggesting that it precipitated during a second fluid pulse. Cal-1 and Cal-2 have similar carbonate rock-buffered chemical and isotopic compositions. Cal-3 occurs in veins that often contain realgar and/or orpiment and are chemically (low U, Pb, and REE) and isotopically (higher δ13C, lower δ18O and Sri values) distinct from Cal-1 and Cal-2, suggesting that it formed from a third fluid. U-Pb isotope analyses, by laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) for U-rich Cal-1 and Cal-2 and by LA-multicollector (MC)-ICP-MS for U-poor Cal-3, yield well-defined age constraints of 204.3 to 202.6, 191.9, and 139.3 to 137.1 Ma for Cal-1, Cal-2, and Cal-3, respectively. These new ages suggest that the Shuiyindong gold deposit formed in the late Triassic and was overprinted by hydrothermal events in the early Jurassic and early Cretaceous. Given the association of Cal-3 with orpiment and realgar, and previous geochronologic studies of several other major gold deposits in the Golden Triangle, we infer that the latest stage of calcite may be associated with an early Cretaceous regional gold metallogenic event. Combined with existing isotopic ages in the region, these new ages lead us to propose that Carlin-type gold deposits in the Golden Triangle formed during two metallogenic episodes in extensional settings, associated with the late Triassic Indochina orogeny and early Cretaceous paleo-Pacific plate subduction. This study shows that the calcite U-Pb method can be used to constrain the timing of Carlin-type gold deposits and successive hydrothermal events.