Throughout the text we have discussed the necessity of sound and comprehensive medical benefit-risk assessment of digital health tools and have introduced the 10 Toxicities: privacy, security, misinformation, charlatanism, cybersecurity, overdiagnosis, cyberchondria, medical device deregulation, and user error. To many, these hazards appear new, evolving, and, possibly, overstated. The truth is, however, that there is preexisting precedent and numerous examples for all of them. This chapter presents five mitigations for these toxicities including awareness and education, a new regulatory paradigm, professionalism and workforce development, and new models of collaboration between health care and law enforcement. Fortunately, it is not too late to get ahead of the hazards of digital health and ensure optimized benefits and minimized risks.