Histories of peyotism in the United States tend to treat it as deeply rooted and universally embraced in indigenous communities. This chapter reminds us that this was not always the case. During its period of rapid growth, from around 1910 to 1940, peyotism was an evangelical religion in most Native American communities and was met with a great deal of resistance. The peyotists were often young men with ties outside of the community, and their practices challenged traditional hierarchies, traditional practices, and older power-brokers in their communities. In some cases, those who opposed peyotism in Native American communities adopted the same language as the missionaries and the Indian Agents in decrying the spread of peyotism, and in at least one case, (on the Navajo reservation in 1940), this prompted the tribal government to ban peyote on the reservation. The ban passed even with the opposition of the U.S. government, which by 1940 supported the rights of peyotists to practice their religion.