Self-reference Network-Related Interactions During the Process of Cognitive Impairment in the Early Stages of Alzheimer’s Disease

Background: Normal establishment of cognition occurs after forming a sensation to stimuli from internal or external cues, in which self-reference processing may be partially involved. However, self-reference processing has been less studied in the Alzheimer’s disease (AD) field within the self-reference network (SRN) and has instead been investigated within the default-mode network (DMN). Differences between these networks have been proven in the last decade, while ultra-early diagnoses have increased. Therefore, investigation of the altered pattern of SRN is significantly important, especially in the early stages of AD.Methods: A total of 65 individuals, including 43 with mild cognitive impairment (MCI) and 22 cognitively normal individuals, participated in this study. The SRN, dorsal attention network (DAN), and salience network (SN) were constructed with resting-state functional magnetic resonance imaging (fMRI), and voxel-based analysis of variance (ANOVA) was used to explore significant regions of network interactions. Finally, the correlation between the network interactions and clinical characteristics was analyzed.Results: We discovered four interactions among the three networks, with the SRN showing different distributions in the left and right hemispheres from the DAN and SN and modulated interactions between them. Group differences in the interactions that were impaired in MCI patients indicated that the degree of damage was most severe in the SRN, least severe in the SN, and intermediate in the DAN. The two SRN-related interactions showed positive effects on the executive and memory performances of MCI patients with no overlap with the clinical assessments performed in this study.Conclusion: This study is the first and primary evidence of SRN interactions related to MCI patients’ functional performance. The influence of the SRN in the ultra-early stages of AD is nonnegligible. There are still many unknowns regarding the contribution of the SRN in AD progression, and we strongly recommend future research in this area.

IMPLEMENTATION OF MULTICULTURAL EDUCATION PROCESS IN ISLAMIC INSTITUTE OF FATTAHUL MULUK PAPUA

This paper examines in depth the implementation of the multicultural education process at IAIN Fattahul Muluk Papua at conceptual and institutional levels. This type of research is qualitative research, the approach used in this research is a multidisciplinary approach with pedagogical, psychological, and sociological approaches. Data sources consist of primary data and secondary data. Data collection techniques through observation, interviews, documentation, literature search and Focus Group Discussion (FGD). The research instrument, namely, the researcher as a key instrument by using the observation theme guide, interview and documentation reference. Processing and data analysis with a model that is condensation Miles and Huberman, data presentation, conclusion and verification. Testing the validity of the data, namely triangulation techniques, checking the correctness of the information, discussing and consulting data, and extending research time. Based on the explanation above, it can be concluded that the implementation of the cultivation of multicultural education values at IAIN Fattahul Muluk Papua through the first conceptual level is realized through planning and formulating the vision, mission, and objectives of IAIN Fattahul Muluk Papua, the second institutional level is implemented through content integration. education in the curriculum) and the internalization of values in learning carried out by stages (a) transforming multicultural values; (b) multicultural value transaction and (c) the application of transinternalization of multicultural values. The three operational levels include curriculum design that is designed based on multicultural values that are applied through the formal curriculum and hidden curriculum (not included in the curriculum) which is unwritten, not programmatically planned but its existence is influential in the application of multicultural education. The four architectural levels are realized through the formation of an adequate and complete multicultural-based physical environment.

Limits on expectation-based processing: Use of grammatical aspect for co-reference in L2

This study examines the use of discourse-level information to create expectations about reference in real-time processing, testing whether patterns previously observed among native speakers of English generalize to nonnative speakers. Findings from a visual-world eye-tracking experiment show that native (L1; N = 53) but not nonnative (L2; N = 52) listeners’ proactive coreference expectations are modulated by grammatical aspect in transfer-of-possession events. Results from an offline judgment task show these L2 participants did not differ from L1 speakers in their interpretation of aspect marking on transfer-of-possession predicates in English, indicating it is not lack of linguistic knowledge but utilization of this knowledge in real-time processing that distinguishes the groups. English proficiency, although varying substantially within the L2 group, did not modulate L2 listeners’ use of grammatical aspect for reference processing. These findings contribute to the broader endeavor of delineating the role of prediction in human language processing in general, and in the processing of discourse-level information among L2 users in particular.

Moral emotions when reading quotidian circumstances in contexts of violence: an fMRI study

The increase of violence in Mexico and consequent suffering during the last decades is evident, but its effects over feelings and moral judgments remain uncertain. We used journalistic news showing real-life situations to investigate the effects of facing violence over the experience of four moral emotions which represent powerful impulses for social actions in situations of suffering linked to violence: Negative Compassion, Positive Compassion, Schadenfreude, and Indignation. We evaluate brain activation by using functional magnetic resonance imaging (fMRI) during three cognitive conditions: reading, introspection, and resting. When reading the news, only Indignation-evoking stimuli elicited salient brain activations in the posterior cerebellum, and temporal and parietal cortical regions, whose functions are related to anger experiences and processing of socially relevant circumstances. When introspecting the emotional experience, cerebellar, frontal, parietal, and occipital activations related to self-focused experiences were observed for all emotions. When resting after facing the stimuli, only the Negative Compassion emotion elicited brain activations in the posterior cingulate cortex and precuneus related to emotional self-reference processing; thus, negative compassion may produce more perdurable cognitive-affective effects related to sadness while perceiving suffering in others. Our results may suggest different emotional-based social decisions to face suffering and violence and to motivate pro-social actions in the collectivistic Mexican culture.

Magnetotelluric Imaging of the Zhangzhou Basin Geothermal Zone, Southeastern China

The geothermal zone of southeast China, which is one of the country’s known geothermal zones, contains significant natural geothermal resources. To understand the formation of geothermal resources, a magnetotelluric (MT) investigation with a site spacing of 1–2 km was carried out around the Zhangzhou Basin. The recorded MT data were processed by robust time series and remote reference processing techniques. The data analysis results revealed that two-dimensional (2-D) modeling can be used to approximately determine the electrical structure. The joint inversions of TE and TM modes have been performed after distortion decomposition. In the inversion models, a low resistivity cap of 200–800 m thickness was observed, which represented the blanketing sediments composed of Quaternary and volcanic rocks of the late Jurassic period. The presence of high resistivity above a depth of 20 km indicates the granites are widely developed in the upper and middle crust. MT measurements have revealed some deep-seated high conductive zones, which were inferred to be partially melting at depth of 8–17 km, which is likely to be reason behind the formation of higher-temperature hot springs. The results also show that there is a shallower Moho, which indicates that the heat from the upper mantle may have a big contribution to the surface heat flow. Fractures-controlled meteoric fluid circulation is the most likely explanation for the hot springs.

Cross-linguistic activation of implicit causality biases in Korean learners of English

This study investigates how the strength of referential biases associated with implicit vs explicit causality predicates in Korean affects Korean-speaking learners’ reference choices in English. Sentence-completion experiments with Korean (Experiment 1a) and English (1b) native speakers showed that Korean speakers referred to the subject more following predicates with explicit vs implicit causality marking, whereas English speakers showed no difference in referential bias for the English translation correspondents of these predicates, which did not contain explicit causality marking. In Experiment 2, Korean learners of English completed an English sentence-completion task, either preceded or followed by a translation task, to test whether strength of referential bias in Korean would affect their referential choices in English. After factoring in individual differences in cross-linguistic associations, results provided evidence that cross-language activation at the word level affects reference processing at a discourse level, with the predicted effect somewhat enhanced by translation priming.