Sonolysis is emerging as an effective advanced technology for destruction of organic pollutants in wastewater. The focus of this study is to investigate the potential of enhancing the sonochemical destruction of aqueous organics. Increasing the contaminant destruction rate will reduce the reaction time, and possibly reduce the cost of treatment. For this purpose, the effect of H2O2 and/or silica in the presence of ultrasound is examined for destruction of 2-chlorophenol (2-CP). The effect of silica dosage (1, 5, 10, and 20 g/L), peroxide dosage (50, 75, and 100 mg/L), and pH (3,7,and 11) is examined. Low solution pH provided higher destruction of 2-CP. The presence of peroxide or silica enhanced the destruction of 2-CP. The optimum silica dosage was 5 g/L. 100 mg/L of peroxide and 5 g/L of silica present together enhanced 2-CP sonolytic destruction by a factor of approximately 2 as compared to 2-CP destruction with ultrasound only.