Unravelling the Anticancer Mechanisms of Traditional Herbal Medicines with Metabolomics

Metabolite profiling of cancer cells presents many opportunities for anticancer drug discovery. The Chinese, Indian, and African flora, in particular, offers a diverse source of anticancer therapeutics as documented in traditional folklores. In-depth scientific information relating to mechanisms of action, quality control, and safety profile will promote their extensive usage in cancer therapy. Metabolomics may be a more holistic strategy to gain valuable insights into the anticancer mechanisms of action of plants but this has remained largely unexplored. This review, therefore, presents the available metabolomics studies on the anticancer effects of herbal medicines commonly used in Africa and Asia. In addition, we present some scientifically understudied ‘candidate plants’ for cancer metabolomics studies and highlight the relevance of metabolomics in addressing other challenges facing the drug development of anticancer herbs. Finally, we discussed the challenges of using metabolomics to uncover the underlying mechanisms of potential anticancer herbs and the progress made in this regard.

Extracting Summary Statistics of Rapid Numerical Sequences

We examine the ability of observers to extract summary statistics (such as the mean and the relative-variance) from rapid numerical sequences of two digit numbers presented at a rate of 4/s. In four experiments (total N = 100), we find that the participants show a remarkable ability to extract such summary statistics and that their precision in the estimation of the sequence-mean improves with the sequence-length (subject to individual differences). Using model selection for individual participants we find that, when only the sequence-average is estimated, most participants rely on a holistic process of frequency based estimation with a minority who rely on a (rule-based and capacity limited) mid-range strategy. When both the sequence-average and the relative variance are estimated, about half of the participants rely on these two strategies. Importantly, the holistic strategy appears more efficient in terms of its precision. We discuss implications for the domains of two pathways numerical processing and decision-making.

A Holistic Strategy for Successful Photovoltaic (PV) Implementation into Singapore’s Built Environment

Based on the findings from a recent study by the authors which examined factors affecting diffusion of photovoltaics (PV), while comprehensively considering the local PV and construction industry as well as characteristics of the built environment, this paper proposes a holistic strategy for PV implementation into Singapore’s built environment. It consists of (1) a multilevel mechanism framework, encompassing eleven mechanism categories of instruments and activities and (2) a general design framework including design principles, general project instructions and the main design guidelines. Relying on a survey conducted among PV experts on established mechanisms, the present study suggests that building codes (e.g., fire safety, structural safety, etc.) and initiatives and incentives related to PV/building-integrated photovoltaics (BIPV) should be the highest priority for authorities, followed by assessment of BIPV/PV properties, working toward social acceptance, conducting research projects and information exchange, and education and training activities. Considering all three pillars of sustainability, the design framework is based on the following interrelated design principles: (1) compatibility and coherence with the local context, (2) technical soundness, (3) economic viability, (4) user-centered design, (5) connecting with community and socio-cultural context, and (6) adaptability and flexibility. Despite Singapore’s scarcity of land, the established design guidelines cover a wide spectrum of solutions, including PV integration into both buildings and non-building structures. The synthesis of the two interconnected and inseparable frameworks aims to create an environment conducive to long-term widespread PV integration and stimulate the deployment of BIPV, which should help Singapore and other cities reduce their dependency on imported fossil fuels, while also making them more livable and enjoyable.

Extracting summary statistics of rapid numerical sequences

We examine the ability of observers to extract summary statistics (such as the mean and the relative-variance) from rapid numerical sequences (two digit numbers presented at a rate of 4/sec). In four experiments, we find that the participants show a remarkable ability to extract such summary statistics and that their precision in the estimation of the sequence-mean improves with the sequence-length (subject to individual differences). Using model selection for individual participants we find that, when they only estimate the sequence average, most participants rely on a holistic process of frequency based estimation and there is a minority who rely on a rule-based and capacity limited mid-range strategy. When both the sequence-average and the relative variance is estimated about half of the participants rely on these two strategies. Importantly, the holistic strategy appears more efficient in terms of its precision. We discuss implications for the domains of two pathways numerical processes and decision-making.

Conclusions

Good analysis must meet three conditions: it must ask questions that have policy relevance; it must build on a plausible set of assumptions about how the world works; and it must recognize the determining nature of context. These conditions inform the book’s proposal for a holistic strategy of conflict management and resolution based on a judicious combination of deterrence, reassurance, and diplomacy. The uncertainty about foreign policy motives makes analysis more difficult, but also creates opportunities for policymakers. To the extent they free themselves from simple mindsets regarding others’ motives and recognize their complexity, they will become increasingly sensitive to the need to understand what motives are at play in any given situation. They will further recognize the possibility of positively influencing the motives of their adversary by reassurance and diplomacy. These strategies have the potential to reduce hostility and pave the way for rapprochement or accommodation.