Design and Development of Lanyard Printing Machine

A Lanyard is an essential part of preparing any company or Organization’s office supplies or stationery. As an ID card holder, Lanyard provides identity and respectability to different organizations. While a simple lanyard is surely practical, a printed and specialized one will undoubtfully leave an enduring effect. To get attractive, brand-relevant satin lanyards to give your company just the right kind of exposure it needs and if employees are participating in conferences and exhibitions, wearing a branded lanyard will help them increase brand awareness. The work involved the design, development, and testing of a Lanyard Printing machine which overcomes the drawback of existing costly printing machines. The design and developmental stages include the gear and chain drive along with the rack and pinion method and their generation mechanisms. Details of a simple, sturdy, and efficient gear and chain unit, financially beneficial to laborers and producers are considered. The unit can print about 80 impressions per minute compared to 30 impressions per minute of existing machines.

Synthesis and Preliminary Biological Evaluation of Two Fluoroolefin Analogs of Largazole Inspired by the Structural Similarity of the Side Chain Unit in Psammaplin A

Largazole, isolated from a marine Cyanobacterium of the genus Symploca, is a potent and selective Class I HDAC (histone deacetylation enzymes) inhibitor. This natural 16-membered macrocyclic depsipeptide features an interesting side chain unit, namely 3-hydroxy-7-mercaptohept-4-enoic acid, which occurs in many other natural sulfur-containing HDAC inhibitors. Notably, one similar fragment, where the amide moiety replaces the trans alkene moiety, appears in Psammaplin A, another marine natural product with potent HDAC inhibitory activities. Inspired by such a structural similarity, we hypothesized the fluoroolefin moiety would mimic both the alkene moiety in Largazole and the amide moiety in Psammaplin A, and thus designed and synthesized two novel fluoro olefin analogs of Largazole. The preliminary biological assays showed that the fluoro analogs possessed comparable Class I HDAC inhibitory effects, indicating that this kind of modification on the side chain of Largazole was tolerable.

Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1)

The first total synthesis of vercopeptin (1), an inhibitor of hypoxia-inducible factor 1 (HIF-1), was achieved via condensation of the depsipeptide core and the polyketide side chain unit.

A combined molecular dynamics simulation and experimental method to study the compatibility between elastomers and resins

Chain/unit level non-bond energy can predict chain/chain level compatibility through MD simulation.

A neptunium(v)-mediated interwoven transuranium-rotaxane network incorporating a mechanically interlocked [c2]daisy chain unit

A combination of an NpV center and a cucurbituril-based pseudorotaxane ligand generates the first transuranium-rotaxane complex, NRCP-1, which has a mechanically-interlocked [c2]daisy chain unit.

New serinolic amino-s-triazines by chemoselective amination of cyanuric chloride and their (pro)diastereomerism in restricted rotational phenomena

The highly chemoselective preparation of new elaborated N-unsymmetrically substituted chlorodiamino-s-triazines and melamines, seen as building-blocks for iterative synthesis, is reported. It consisted of amination of cyanuric chloride with commercial C-2-substituted 2-aminopropane-1,3-diols (“serinols”), playing the role as “open-chain” unit and enantiopure (1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diols (“p-nitrophenylserinols”) based amino-1,3-dioxanes (“closed-chain” unit). Issued from the restricted rotation about C(s-triazine)-N(exocyclic) partial double bonds, seen as axes of (pro)diastereomerism, a global four-component rotational equilibrium involving the title compounds is discussed based on DFT computation and (VT) NMR data. Depending on π-deficiency of the s-triazine core, an (un)synchronised deblocking of the generated rotational diastereomers was observed. They are discussed as influence of intra-vs. intermolecular NH...OH (dynamic) interactions occurring in the “open-chain” unit and the anancomeric, axial vs. equatorial, amino-anchorage of the “closed-chain” unit.