Assessment of the state of personal and situational anxiety and indicators of stress-implementing and stress-limiting systems of the organism as marker efficiency the antenatal preparation

As a result of research conducted on the basis of the State Institution «Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova NAMS of Ukraine», the issue of the transcranial electrostimulation introduction in preparation for partnership labor was shown. Purpose — to study the features of changes in the state of personal and situational anxiety, stress-implementing and stress-limiting systems of the body in healthy women depending on the method of prenatal training. Materials and methods. 120 somatically healthy women without severe extragenital and obstetric pathology with a physiological course of singleton pregnancy were examined. In the first group — 45 women set up for partner childbirth, the second group also included 45 patients who underwent a course of transcranial electrical stimulation (TES) of mesodiencephalic structures of the brain in comprehensive preparation for partner childbirth. The control group included 30 women who did not receive prenatal training, did not have individual support in childbirth and were tuned to traditional methods of pain relief as needed. Results. Following the results of the determination of pain rate in the dynamic of the TES procedure, a progressive growth of the pain tolerance threshold was recorded with the subsequent stabilization of this value after the 5th procedure of electrical stimulation. Methods of psychophysical preparation for childbirth using transcranial electrostimulation and partner support made it possible to reduce medical induced pain relief during childbirth, which is what the data we obtained indicate. Conclusions. The use of TES in complex prenatal preparation for partner labor allows to achieve and maintain a stable psycho-emotional adaptation of pregnant women and increases the tolerance of the consonant to labor pain without additional medication load, which helps to make more physiological course of labor. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local ethics committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: labor, prenatal preparation, transcranial electrostimulation, pain threshold, anesthesia, partnership labor.

Evaluation of the effectiveness of transcranial electrostimulation in treatment of neuropsychiatric disorders

Objectives: Evaluation of the effectiveness the method of transcranial electrostimulation in treatment of neuropsychiatric disorders with the use of a patches by the company “Aganyan”. Materials and methods: The study was a double-blind, randomized, placebo-controlled study, participated 106 patients with neuropsychiatric disorders. All participants in were divided into tables according to gender, age and diagnosis. Each subject was given the “Aganyan” patches and a special brochure, in which the method of application was indicated in detail. The wearable patch includes a flexible substrate, a binder an adhesive layer, with an electrode foil attached to it. Patients applied one patch behind each ear. The patches were applied for eight hours every third day for three months. To assess the effectiveness of therapy in patients the following tests were used: The Montreal Cognitive Assessment Scale; MMSE Scale: Concise Mental Status Scale; diaries of observation of the patient’s condition to identify side effects; special brochures in which the subjects independently indicated the effects of the “Aganyan” patches. Tests were performed before and after the use of the “Aganyan” patches. Results: When using the patches of the “Aganyan” company, none of the participants in the study had any side effects; According to the results of the Montreal test according to the criterion of memory and the MMSE test, the effectiveness of the patch was noted in patients with all clinical diagnoses. The greatest positive dynamics was revealed according to the results of the Montreal test according to the criterion of memory in patients with migraine (30%), insomnia (31%), vascular dementia (32%), and according to the results of the MMSE test in patients with diagnoses: cerebrovascular disease: consequences of a cerebral infarction brain (31%), vascular dementia (56%). Conclusion: The patches of “Aganyan” company have proven its effectiveness through electrical stimulation with low-intensity current in patients in different age groups with different clinical diagnoses.

Transcranial electrostimulation with special waveforms enhances upper-limb motor function in patients with chronic stroke: a pilot randomized controlled trial

Background Transcranial direct current stimulation (tDCS) and intermittent theta burst stimulation (iTBS) were both demonstrated to have therapeutic potentials to rapidly induce neuroplastic effects in various rehabilitation training regimens. Recently, we developed a novel transcranial electrostimulation device that can flexibly output an electrical current with combined tDCS and iTBS waveforms. However, limited studies have determined the therapeutic effects of this special waveform combination on clinical rehabilitation. Herein, we investigated brain stimulation effects of tDCS-iTBS on upper-limb motor function in chronic stroke patients. Methods Twenty-four subjects with a chronic stroke were randomly assigned to a real non-invasive brain stimulation (NIBS; who received the real tDCS + iTBS output) group or a sham NIBS (who received sham tDCS + iTBS output) group. All subjects underwent 18 treatment sessions of 1 h of a conventional rehabilitation program (3 days a week for 6 weeks), where a 20-min NIBS intervention was simultaneously applied during conventional rehabilitation. Outcome measures were assessed before and immediately after the intervention period: Fugl-Meyer Assessment-Upper Extremity (FMA-UE), Jebsen-Taylor Hand Function Test (JTT), and Finger-to-Nose Test (FNT). Results Both groups showed improvements in FMA-UE, JTT, and FNT scores after the 6-week rehabilitation program. Notably, the real NIBS group had greater improvements in the JTT (p = 0. 016) and FNT (p = 0. 037) scores than the sham NIBS group, as determined by the Mann–Whitney rank-sum test. Conclusions Patients who underwent the combined ipsilesional tDCS-iTBS stimulation with conventional rehabilitation exhibited greater impacts than did patients who underwent sham stimulation-conventional rehabilitation in statistically significant clinical responses of the total JTT time and FNT after the stroke. Preliminary results of upper-limb functional recovery suggest that tDCS-iTBS combined with a conventional rehabilitation intervention may be a promising strategy to enhance therapeutic benefits in future clinical settings. Trial registration: ClinicalTrials.gov Identifier: NCT04369235. Registered on 30 April 2020.

Application of therapeutic complex with cytoflavin pills, transcranial electrostimulation and magnetic-laser therapy in patients with vertebrobasilar insufficiency

An examination and treatment of 120 patients with circulatory failure in the vertebral-basilar basin was carried out. We studied the hemodynamic state of arterial and venous cerebral blood flow (ultrasound, magnetic resonance angiography, phlebography). We evaluated the dynamics of subjective and objective clinical, hemodynamic parameters before treatment and against the background of the combination therapy. The high efficiency of the influence of the treatment complex with the use of cytoflavin in tablets, transcranial electrical stimulation, magnetolaser effects on the dynamics of clinical and functional indicators, and a reduction in hospital stay in patients with circulatory failure in the WB has been shown to be highly effective.