An Occupancy Mapping Method Based on K-Nearest Neighbours

OctoMap is an efficient probabilistic mapping framework to build occupancy maps from point clouds, representing 3D environments with cubic nodes in the octree. However, the map update policy in OctoMap has limitations. All the nodes containing points will be assigned with the same probability regardless of the points being noise, and the probability of one such node can only be increased with a single measurement. In addition, potentially occupied nodes with points inside but traversed by rays cast from the sensor to endpoints will be marked as free. To overcome these limitations in OctoMap, the current work presents a mapping method using the context of neighbouring points to update nodes containing points, with occupancy information of a point represented by the average distance from a point to its k-Nearest Neighbours. A relationship between the distance and the change in probability is defined with the Cumulative Density Function of average distances, potentially decreasing the probability of a node despite points being present inside. Experiments are conducted on 20 data sets to compare the proposed method with OctoMap. Results show that our method can achieve up to 10% improvement over the optimal performance of OctoMap.

Spatial Probabilistic Mapping of Metabolite Ensembles in Mass Spectrometry Imaging

Mass spectrometry imaging (MSI) vows to enable simultaneous spatially-resolved investigation of hundreds of metabolites in tissue sections, but it still relies on poorly defined ion images for data interpretation. Here, we outline moleculaR, a computational framework in R, that introduces systematic probabilistic mapping and point-for-point statistical testing of metabolites in tissue to MSI. Beyond statistics, moleculaR allows for arithmetic operations within the same MS image and thereby, for instance, analysis and visualization of complex scores like the adenylate energy charge ([ATP]+0.5*[ADP])/ ([ATP]+[ADP]+[AMP]). moleculaR also enables collective molecular projections, for example of all potassium versus all sodium adducts for spatially-resolved investigation of ion milieus, or for surveys of lipid pathways or other user-defined biomolecular ensembles.

Spatial Probabilistic Mapping of Metabolite Ensembles in Mass Spectrometry Imaging

Mass spectrometry imaging (MSI) vows to enable simultaneous spatially-resolved investigation of hundreds of metabolites in tissue sections, but it still relies on poorly defined ion images for data interpretation. Here, we outline moleculaR, a computational framework (https://github.com/CeMOS-Mannheim/moleculaR) that introduces probabilistic mapping and point-for-point statistical testing of metabolites in tissue. It enables collective molecular projections and consequently spatially-resolved investigation of ion milieus, lipid pathways or user-defined biomolecular ensembles within the same image.

Disrupted state transition learning as a computational marker of compulsivity

Background Disorders involving compulsivity, fear, and anxiety are linked to beliefs that the world is less predictable. We lack a mechanistic explanation for how such beliefs arise. Here, we test a hypothesis that in people with compulsivity, fear, and anxiety, learning a probabilistic mapping between actions and environmental states is compromised. Methods In Study 1 (n = 174), we designed a novel online task that isolated state transition learning from other facets of learning and planning. To determine whether this impairment is due to learning that is too fast or too slow, we estimated state transition learning rates by fitting computational models to two independent datasets, which tested learning in environments in which state transitions were either stable (Study 2: n = 1413) or changing (Study 3: n = 192). Results Study 1 established that individuals with higher levels of compulsivity are more likely to demonstrate an impairment in state transition learning. Preliminary evidence here linked this impairment to a common factor comprising compulsivity and fear. Studies 2 and 3 showed that compulsivity is associated with learning that is too fast when it should be slow (i.e. when state transition are stable) and too slow when it should be fast (i.e. when state transitions change). Conclusions Together, these findings indicate that compulsivity is associated with a dysregulation of state transition learning, wherein the rate of learning is not well adapted to the task environment. Thus, dysregulated state transition learning might provide a key target for therapeutic intervention in compulsivity.

Outlier Detection in Wellness Data using Probabilistic Mapped Mean-Shift Algorithms

In this paper, the Probabilistic Mapped Mean-Shift Algorithm is proposed to detect anomalous data in public datasets and local hospital children’s wellness clinic databases. The proposed framework consists of two main parts. First, the Probabilistic Mapping step consists of k-NN instance acquisition, data distribution calculation, and data point reposition. Truncated Gaussian Distribution (TGD) was used for controlling the boundary of the mapped points. Second, the Outlier Detection step consists of outlier score calculation and outlier selection. Experimental results show that the proposed algorithm outperformed the existing algorithms with real-world benchmark datasets and a Children’s Wellness Clinic dataset (CWD). Outlier detection accuracy obtained from the proposed algorithm based on Wellness, Stamps, Arrhythmia, Pima, and Parkinson datasets was 93%, 94%, 80%, 75%, and 72%, respectively.