Voice Biomarkers as Possible Indicators of Cognitive Aging

There is emerging evidence that measures of voice prosody are related to diagnoses of Alzheimer’s Disease and Related Disorders. The goal of this study was to examine whether voice prosody measures (pitch, pulse, voice breaks, jitter, shimmer, and amplitude) are also related to individual differences in normal cognitive aging. Data are from the Midlife in the United States Wave 2 (M2) and Wave 3 (M3) for 2693 participants (ages 42-92 at M3) who completed the M2 and M3 Brief Test of Adult Cognition by Telephone (BTACT) and had M3 voice recordings. Voice variables were measured from cognitive interviews using three cognitive tests and averaged to create a composite for each voice variable. Voice prosody was related to age, sex, education, and health, which were included as covariates. Older adults, men, and those with more health conditions had higher jitter and shimmer. Older adults, women, and those with higher education and better health had more voice breaks. Hierarchical regression models, controlling for the covariates, examined the voice composites as predictors of each cognitive measure at M3 and change over 9 years from M2 to M3. As hypothesized, higher jitter predicted lower performance and greater decline on memory, category fluency, and attention. Contrary to predictions, a lower number of voice breaks predicted worse performance and greater declines on all cognitive tests. The results suggest that voice biomarkers are related to cognitive performance and decline, and they may offer a promising approach for identifying early signs of cognitive impairment or dementia.

Cognition Moderates the Relationship Between Hearing and Mobility in Cognitively Normal Older Adults

Recent data has shown a consistent but modest association between hearing impairment and poor mobility; both are strongly associated with cognition. Cognitive function may moderate the relationship between hearing and mobility. We analyzed 601 cognitively normal older participants from the Baltimore Longitudinal Study of Aging who had concurrent data on cognition (attention, executive function, sensorimotor function), hearing (pure-tone average, PTA), and mobility (6-meter gait speed, 400-meter time). We performed multivariable-adjusted linear regression to test two-way interactions between each cognitive measure and PTA. There were significant PTA interactions with all cognitive measures on 400-meter time. There was a significant interaction between PTA and sensorimotor function on 6-meter gait speed. Among cognitively normal older adults, poorer hearing is more strongly associated with poor mobility in those with low cognition, especially sensorimotor function. Future studies are needed to understand how cognition may moderate the relationship of hearing impairment with mobility decline over time.

Developing an Ontology Evaluation Methodology: Cognitive Measure of Quality

<p>Ontologies are formal specifications of shared conceptualizations of a domain. Important applications of ontologies include distributed knowledge based systems, such as the semantic web, and the evaluation of modelling languages, e.g. for business process or conceptual modelling. These applications require formal ontologies of good quality. In this thesis, we present a multi-method ontology evaluation methodology, which consists of two techniques (sentence verification task and recall) based on principles of cognitive psychology, to test how well a specification of a formal ontology corresponds to the ontology users' conceptualization of a domain. Two experiments were conducted, each evaluating the SUMO ontology and WordNet with an experimental technique, as demonstrations of the multi-method evaluation methodology. We also tested the applicability of the two evaluation techniques by conducting a replication study for each. The replication studies obtained findings that point towards the same direction as the original studies, although no significance was achieved. Overall, the evaluation using the multi-method methodology suggests that neither of the two ontologies we examined is a good specification of the conceptualization of the domain. Both the terminology and the structure of the ontologies, may benefit from improvement.</p>

Developing an Ontology Evaluation Methodology: Cognitive Measure of Quality

<p>Ontologies are formal specifications of shared conceptualizations of a domain. Important applications of ontologies include distributed knowledge based systems, such as the semantic web, and the evaluation of modelling languages, e.g. for business process or conceptual modelling. These applications require formal ontologies of good quality. In this thesis, we present a multi-method ontology evaluation methodology, which consists of two techniques (sentence verification task and recall) based on principles of cognitive psychology, to test how well a specification of a formal ontology corresponds to the ontology users' conceptualization of a domain. Two experiments were conducted, each evaluating the SUMO ontology and WordNet with an experimental technique, as demonstrations of the multi-method evaluation methodology. We also tested the applicability of the two evaluation techniques by conducting a replication study for each. The replication studies obtained findings that point towards the same direction as the original studies, although no significance was achieved. Overall, the evaluation using the multi-method methodology suggests that neither of the two ontologies we examined is a good specification of the conceptualization of the domain. Both the terminology and the structure of the ontologies, may benefit from improvement.</p>

A Cognitive Measure of Entrepreneurial Alertness

Alertness is a foundational concept in current understandings of the spotting and exploitation of entrepreneurial opportunities. Yet, despite being identified as a key theoretical construct of individual entrepreneurs, its cognitive features are not fully described in the literature. And as a result, the existing instruments for measuring this cognitive feature of entrepreneurs do not fully reflect the broad nature of this concept. In this study, the cognitive theoretical basis of alertness is reviewed and a new scale, which better reflects the broader cognitive features of entrepreneurial alertness, is presented. This may assist the validity of future empirical studies that involve entrepreneurial alertness.

The Relationship Between Central Auditory Tests and Neurocognitive Domains in Adults Living With HIV

Objective: Tests requiring central auditory processing, such as speech perception-in-noise, are simple, time efficient, and correlate with cognitive processing. These tests may be useful for tracking brain function. Doing this effectively requires information on which tests correlate with overall cognitive function and specific cognitive domains. This study evaluated the relationship between selected central auditory focused tests and cognitive domains in a cohort of normal hearing adults living with HIV and HIV– controls. The long-term aim is determining the relationships between auditory processing and neurocognitive domains and applying this to analyzing cognitive function in HIV and other neurocognitive disorders longitudinally.Method: Subjects were recruited from an ongoing study in Dar es Salaam, Tanzania. Central auditory measures included the Gap Detection Test (Gap), Hearing in Noise Test (HINT), and Triple Digit Test (TDT). Cognitive measures included variables from the Test of Variables of Attention (TOVA), Cogstate neurocognitive battery, and Kiswahili Montreal Cognitive Assessment (MoCA). The measures represented three cognitive domains: processing speed, learning, and working memory. Bootstrap resampling was used to calculate the mean and standard deviation of the proportion of variance explained by the individual central auditory tests for each cognitive measure. The association of cognitive measures with central auditory variables taking HIV status and age into account was determined using regression models.Results: Hearing in Noise Tests and TDT were significantly associated with Cogstate learning and working memory tests. Gap was not significantly associated with any cognitive measure with age in the model. TDT explained the largest mean proportion of variance and had the strongest relationship to the MoCA and Cogstate tasks. With age in the model, HIV status did not affect the relationship between central auditory tests and cognitive measures. Age was strongly associated with multiple cognitive tests.Conclusion: Central auditory tests were associated with measures of learning and working memory. Compared to the other central auditory tests, TDT was most strongly related to cognitive function. These findings expand on the association between auditory processing and cognitive domains seen in other studies and support evaluating these tests for tracking brain health in HIV and other neurocognitive disorders.

Cognitive and Central Vestibular Functions Correlate in People With Multiple Sclerosis

Background. Cognitive impairment is common, but poorly managed in people with multiple sclerosis (MS). Balance has been correlated with cognition in people with MS, potentially through shared utilization of central sensory integration pathways. Objective. This study characterized the relationship between central vestibular integration and cognition in people with MS through measurement of several clinical vestibular functions requiring central sensory integration and multiple cognitive domains. Methods. Forty people with MS and 20 controls completed a battery of vestibular and cognitive examinations targeting different central vestibular integration measures and different domains of cognition, respectively. Performance on these measures was compared between people with MS and controls, and then correlational analyses were undertaken between the vestibular and cognitive measures in the MS sample. Results. People with MS performed worse than controls on all vestibular and cognitive measures. There were consistent correlations between vestibular and cognitive measures in the MS sample. Factor analysis of vestibular functions yielded a single factor hypothesized to represent central vestibular integration that demonstrated a significant relationship with a composite cognitive measure in people with MS. Discussion. Our results suggest that vestibular and cognitive dysfunction may both arise from central sensory processing pathways in people with MS. This connection could be targeted through vestibular rehabilitation techniques that improve central sensory processing and both balance and cognition in people with MS.

The International Cognitive Ability Resource: A Free Cognitive Measure With Utility for Postsecondary Giftedness Research

Research on high-ability postsecondary students has increased in recent years; yet identifying such students can be challenging. The International Cognitive Ability Resource (ICAR) is an online, open-access tool designed to facilitate measurement of cognitive abilities in research. We evaluated whether the ICAR is appropriate to identify high-ability postsecondary students for research; high ability was classified by a General Ability Index score of 120 or higher on the WAIS-IV. In a sample of 97 students from a U.S. university (Mean age 22.47 years, Mean General Ability Index score 115.13) the 60-item ICAR demonstrated adequate diagnostic accuracy to identify high ability with three appropriate cut scores (33, 34, or 35 items correct out of 60). The 16-item ICAR had no appropriate cut scores but demonstrated validity as a brief cognitive ability measure that could be used to examine relations between intelligence and other variables. Findings suggest that the ICAR could be a useful open-source tool for research with high-ability college students