MECHANOCHEMICAL MODIFICATION OF TRICLABENDAZOLE FOR THE PRODUCTION OF AN EFFECTIVE ANTI-FASCILOID DRUG

Continuing a series of studies to increase the solubility of the known substance triclabendazole (TСB), the technology of mechanochemical modification was used with a mixture of polymers-polyvinylpyrrolidone (PVP) and arabinogalactan (AG) with the addition of the known emulsifier – sodium dioctyl sulfosuccinate (SDN). In this case, solid dispersions (SD) of TCB compositions were obtained: TCB : PVP = 1: 9, TCB : PVP : AG = 1: 4.5: 4.5 and TCB : PVP : AG : SDN = 1: 4.5: 4.5: 0.1, which are easily loose powders that form stable suspensions in water when preparing working solutions for use in animals. A significant improvement in the solubility (almost 30 times) of the obtained SDs with the addition of SDN was established, which allows us to hope for their high antifascioid activity. Drugs can also be used for use by adding to animal feed. Currently, the drug is being tested in laboratory and industrial conditions. According to preliminary data, drugs with the addition of SDN are of interest and additional studies are required for implementation in veterinary practice.

Optimal Design of Alkaline–Surfactant–Polymer Flooding under Low Salinity Environment

This paper presents an optimal design of alkaline–surfactant–polymer (ASP) flooding and an experimental analysis on the effects of ASP components under low formation salinity, where the assignment of salinity gradients and various phase types are limited. The phase behavior and coreflooding tests confirmed the ASP formula is optimal, i.e., 1 wt % sodium carbonate (Na2CO3) as the alkaline, 1:4 weight ratio for linear alkylbenzene sulfonate (LAS) and dioctyl sulfosuccinate (DOSS) as a surfactant, 5 wt % diethylene glycol monobutyl ether (DGBE) as a co-solvent, and hydrolyzed polyacrylamide (HPAM) as a polymer. The salinity scan was used to determine that the optimum salinity was around 1.25 wt % NaCl and its solubilization ratio was favorable, i.e., approximately 21 mL/mL. The filtration ratio determines the polymer concentrations, i.e., 3000 or 3300 mg/L, with a reduced risk of plugging through pore throats. The coreflooding test confirmed the field applicability of the proposed ASP formula with an 86.2% recovery rate of residual oil after extensive waterflooding. The optimal design for ASP flooding successfully generated phase types through the modification of salinity and can be applicable to the low-salinity environment.

Electrochemical synthesis and characterizations of new nanocomposite electrodeposition on Co67Cr29W4 alloy substrate

In this study, galvanostatic electrodeposition techniques were employed for the achieved of new composite polymer: polypyrrole - sodium dioctyl sulfosuccinate/poly N-ethylaniline (PPY-AOT/PNEA) coatings on the Co67Cr29W4 alloy electrode surface. The PPYAOT/PNEA coating has been synthesized on the Co67Cr29W4 alloy electrode by galvanostatic deposition from aqueous solutions 0.1 M NEA, 0.1M PY, 0.01 M AOT and 0.5 M H2SO4 solution at various current densities (1mA/cm2 , 2mA/cm2 and 8mA/cm2 ) in different molar ratio. The sodium dioctyl sulfosuccinate (AOT) as a dopant ion used in electropolymerization process be able to a significant influence on the electrochemical activity of the composite polymer. The polymeric composite coatings were characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and scanning electron microscopy (SEM) techniques. The results denoted that the electroactive behaviors of the composite polymer mainly depend on the molar ratio of monomers, the applied density current and times of electrodeposition. It has been established that the cobalt based alloy substrate had a meaningful influence on the electrochemical activity of the polypyrrole and poly(N-ethylaniline) composite films and that as in the existence of polymeric film, anodization of these modified electrodes obtained in constitution of an oxides complex film and polymeric layers together. All of the composite films were a very promising electrode material for application in supercapacitor, corrosion protection coatings or sensor employments.

Counterion binding on coacervation of dioctyl sulfosuccinate in aqueous sodium chloride

A simple coacervate-forming system consisting of sodium dioctyl sulfosuccinate (DOSS) in aqueous NaCl solution was investigated by turbidity measurement, electromotive force measurement (EMF), dynamic light scattering (DLS), and cryogenic transmission electron microscopy (cryo-TEM) to reveal the role of counterion binding in the microstructural changes behind the evolution of the coacervate phase.