High Return to Sport in Patients Over 45 Years of Age Undergoing Osteochondral Allograft Transplantation for Isolated Chondral Defects in the Knee

Objective: The purpose of this study was to evaluate the efficacy of osteochondral allograft (OCA) in patients older than 45 years of age, particularly with respect to return to sport. Design: A retrospective review was performed to evaluate patients greater than 45 who underwent an OCA for a symptomatic osteochondral defect of the knee between June 2011 and January 2019. Results: Overall, there were 18 patients (76% male) that met our inclusion and exclusion criteria. Follow-up was attained in 14 of these patients (78%). The mean age of patients included was 52.6 years (48-57) with a mean of 37 months of follow-up (18-60). Visual Analogue Scale scores decreased significantly from the preoperative baseline to final follow-up (7.7 ± 1.7 vs. 2.0 ± 2.0, P < 0.01). Furthermore, the mean Visual Analogue Scale while playing sport was 3.4 ± 3.2, and the mean Knee Injury and Osteoarthritis Outcome Score was 77.5 ± 12.7 at final follow-up. Overall, 11 patients (78.6%) were able to return to their desired sport. No clinical failures were identified during the follow-up period. Conclusion: In our series of patients 45 years and older who were treated with OCA for focal osteochondral injuries of the knee, we found a significant improvement in clinical outcome scores at a midterm follow-up of 37 months with no revision OCA procedures or conversion to any form of knee arthroplasty. In addition, a high percentage of patients were able to return to their preferred level of athletic activity.

Bilateral femoral head reshaping and mosaicplasty in Legg–Calvé–Perthes disease residual deformity

Residual hip deformity secondary to Perthes disease may lead to early symptomatic joint degeneration. The altered anatomy results in biomechanical and biological problems that can be surgically addressed in adolescents or young adults with hip preservation procedures. This case report aims to demonstrate a customized surgical treatment performed on a 15-year-old male who developed painful hips with significant intra- and extra-articular impingement, secondary to bilateral Leg–Calvé–Perthes disease residual deformity. Intra-articular procedures were executed through a safe surgical dislocation of the hip, with a mosaicplasty using osteochondral autografts from the exceeding peripheral ipsilateral femoral head, a femoral head–neck osteochondroplasty and a labrum repair. A relative lengthening of the femoral neck was also carried out with a trochanteric advancement to solve the extra-articular issues. On follow-up, he referred to a substantial improvement in pain and function, being his radiographic studies satisfactory. At 4 and 5 years from surgery, the patient was able to exercise regularly with minimal complaints, with a Harris Hip Score of 85.85% and a Hip Outcome Score of 94.1% for activities of daily life and 86.1% for sports. In patients with hip deformity after healed Perthes disease, treatment strategies that address both the morphological disturbance of coxa magna, plana and breva, as well as the biological concerns arising from osteochondral injuries or labral tears, and mechanical dysfunctions lead to improvements in symptomatology, function and medium-term prognosis. Further procedures to address residual adaptative acetabular dysplasia would favor outcomes of conservative hip surgery in the sequelae of LCPD.

Osteochondral Lesions of the Talus: A Review on Talus Osteochondral Injuries, Including Osteochondritis Dissecans

This is a review on talus osteochondritis dissecans and talus osteochondral lesions. A majority of the osteochondral lesions are associated with trauma while the cause of pure osteochondritis dissecans is still much discussed with a possible cause being repetitive microtraumas associated with vascular disturbances causing subchondral bone necrosis and disability. Symptomatic nondisplaced osteochondral lesions can often be treated conservatively in children and adolescents while such treatment is less successful in adults. Surgical treatment is indicated when there is an unstable cartilage fragment. There are a large number of different operative technique options with no number one technique to be recommended. Most techniques have been presented in level II to IV studies with a low number of patients with short follow ups and few randomized comparisons exist. The actual situation in treating osteochondral lesions in the ankle is presented and discussed.

Knee injuries: correlation of MRI with arthroscopic findings

Introduction: Knee injuries are common among active adults. Achieving a correct clinical diagnosis is often difficult in acute presentations. Knee arthroscopy is considered the gold standard in diagnosing post-traumatic intra-articular lesions, but it is an invasive procedure requiring a certain degree of expertise. Magnetic Resonance Imaging (MRI) is a non-invasive, sensitive diagnostic tool for knee injuries. This study aims to correlate the findings of MRI with arthroscopy of the knee. Method: This Prospective Observational Study was done at Shree Birendra Hospital, Kathmandu, Nepal from 13 Feb 2016 to 13 Jun 2016. The sensitivity, specificity, and accuracy of MRI findings in ligamentous, meniscal, and osteochondral injuries of the knee were analyzed using arthroscopic findings as standard. Result: Fifty-two patients (35 male and 17 female), mean age 35.4 years were included in the study. The accuracy of MRI for anterior cruciate ligament (ACL), posterior cruciate ligament (PCL), medial meniscus, lateral meniscus, and chondral lesions of the knee were 94%, 100%, 92%,86%, and 86% respectively. Conclusion: The MRI is accurate (86-94%) in diagnosing Meniscal and Ligamentous injuries of the knee. It has poor sensitivity (22%) for chondral lesions.

Exploratory Full-Field Mechanical Analysis across the Osteochondral Tissue—Biomaterial Interface in an Ovine Model

Osteochondral injuries are increasingly prevalent, yet success in articular cartilage regeneration remains elusive, necessitating the development of new surgical interventions and novel medical devices. As part of device development, animal models are an important milestone in illustrating functionality of novel implants. Inspection of the tissue-biomaterial system is vital to understand and predict load-sharing capacity, fixation mechanics and micromotion, none of which are directly captured by traditional post-mortem techniques. This study aims to characterize the localised mechanics of an ex vivo ovine osteochondral tissue–biomaterial system extracted following six weeks in vivo testing, utilising laboratory micro-computed tomography, in situ loading and digital volume correlation. Herein, the full-field displacement and strain distributions were visualised across the interface of the system components, including newly formed tissue. The results from this exploratory study suggest that implant micromotion in respect to the surrounding tissue could be visualised in 3D across multiple loading steps. The methodology provides a non-destructive means to assess device performance holistically, informing device design to improve osteochondral regeneration strategies.

Micropartículas de PLLA y CHT como andamiaje para la regeneración del cartílago articular: Modelo animal.

The avascular nature of cartilaginous tissue has historically lead to bad prognosis in osteochondral injuries. One of the possible treatment options of these injuries is the use of scaffolds, being superior to other options that obtain a fibrous cartilage as a result. We have elaborated PLLA and CHT microspheres as a scaffold for the treatment of osteochondral injuries carried out in albine New Zealand rabbits. They were distributed into groups with different proportions of microspheres, having also a control group with untreated injuries. Native cartilage of the contralateral knees was also analysed. Samples were evaluated in order to establish the quality of the cartilage obtained (using de macroscopic ICRS, microscopic ICRS II scales and a histomorphometric study).The groups with microspheres obtained a regeneration cartilage with hyaline characteristics, a good cell distribution and regular surface. The control group resulted in a cartilage with worse organization and an irregular surface.

DOES THE NUMBER OF PATELLOFEMORAL INSTABILITY EPISODES CORRELATE WITH THE PREVALENCE AND SEVERITY OF CHONDRAL AND OSTEOCHONDRAL LESIONS IN PEDIATRIC AND ADOLESCENT PATIENTS?

Disclosures: None Background: Current literature indicates that the risk of chondral and osteochondral injuries following patellofemoral instability events ranges from 40 to 96%. It is unclear based on current literature if there is an association between the number of instability events and the prevalence and severity of chondral and osteochondral injuries. Hypothesis/Purpose: The purpose of this study was to investigate the prevalence and severity of chondral and osteochondral injury following patellar dislocations based on number of dislocations and accounting for other patellofemoral instability risk factors (patella alta, trochlear dysplasia, growth status). Methods: Retrospective chart review was performed for patients under the age of 18 years with a prior history of traumatic patellar dislocation, documented number of instability events, and MRI available for review. Patients were grouped into those with 1 dislocation and >1 dislocation. A priori power analysis based on previous literature demonstrated a required minimum of 82 patients in each group (alpha=.05, power=90%, p1= 70%, p2=90%). Chart review was performed on all patients with diagnosis of patellofemoral instability for past 3 years to determine inclusion and record number of dislocations. MRI and radiographs were independently reviewed by a Musculoskeletal Radiologist and Orthopaedic Surgeon. Chondral injury severity (none, partial thickness, full thickness, osteochondral), location of injury, skeletal maturity, Caton-Deschamps index (CDI), and sulcus angle were recorded. Any discrepancies were settled by review by senior author. Poisson multivariate regression, chi-square, and descriptive statistics were used as appropriate. Results: 99 patients were included in each group. There was no statistically significant difference in the prevalence of chondral injury between patients with one dislocation versus more than one dislocation (64.65% versus 55.56%, p=.19) (Table 1). Multivariate regression analysis determined that no factor (patella alta, trochlear dysplasia, skeletal maturity, number of dislocations) was associated with prevalence of chondral injury. Multivariate regression analysis determined patella alta (CDI >1.3) was a significant factor in severity of chondral injury (p=.016). Conclusion: A history of multiple patellar dislocations is not associated with a higher prevalence or increased severity of chondral injury compared to a single patellar dislocation event. In patients with patella alta, a lower threshold for surgical management may be warranted due to its association with more severe cartilage injury, if not already present. [Table: see text]