scholarly journals A fluorescent molecular imaging probe with selectivity for soluble tau aggregated protein

2020 ◽  
Vol 11 (18) ◽  
pp. 4773-4778
Author(s):  
Yanyan Zhao ◽  
Ole Tietz ◽  
Wei-Li Kuan ◽  
Abdul K. Haji-Dheere ◽  
Stephen Thompson ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Neurodegenerative Diseases ◽  
Imaging Probe ◽  
Bold Imaging ◽  
Molecular Imaging Probe

pTP-TFE imaging probe can distinguish soluble tau aggregated proteins from other aggregated proteins enabling earlier detection of neurodegenerative diseases.

scholarly journals Techniques for Molecular Imaging Probe Design

2011 ◽  
Vol 10 (6) ◽  
pp. 7290.2011.00003 ◽  
Author(s):  
Fred Reynolds ◽  
Kimberly A. Kelly
Keyword(s):  
Molecular Imaging ◽  
Target Selection ◽  
Relevant Information ◽  
Probe Design ◽  
Imaging Probe ◽  
Molecular Imaging Probes ◽  
Genomics And Proteomics ◽  
Imaging Probes ◽  
Molecular Imaging Probe ◽  
Underlying Mechanisms

Molecular imaging allows clinicians to visualize disease-specific molecules, thereby providing relevant information in the diagnosis and treatment of patients. With advances in genomics and proteomics and underlying mechanisms of disease pathology, the number of targets identified has significantly outpaced the number of developed molecular imaging probes. There has been a concerted effort to bridge this gap with multidisciplinary efforts in chemistry, proteomics, physics, material science, and biology—all essential to progress in molecular imaging probe development. In this review, we discuss target selection, screening techniques, and probe optimization with the aim of developing clinically relevant molecularly targeted imaging agents.

An in vivo molecular imaging probe 18F-Annexin B1 for apoptosis detection by PET/CT: preparation and preliminary evaluation

APOPTOSIS ◽  
2012 ◽  
Vol 18 (2) ◽  
pp. 238-247 ◽  
Author(s):  
Ming-Wei Wang ◽  
Fang Wang ◽  
Yu-Jia Zheng ◽  
Ying-Jian Zhang ◽  
Yong-Ping Zhang ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Preliminary Evaluation ◽  
Imaging Probe ◽  
Pet Ct ◽  
Apoptosis Detection ◽  
Molecular Imaging Probe ◽  
Annexin B1

scholarly journals Breast cancer cell targeted MR molecular imaging probe: Anti-MUC1 antibody-based magnetic nanoparticles

2017 ◽  
Vol 851 ◽  
pp. 012014 ◽  
Author(s):  
P Moradi Khaniabadi ◽  
A. M. S.A Majid ◽  
M Asif ◽  
B Moradi Khaniabadi ◽  
D Shahbazi-Gahrouei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Nanoparticles ◽  
Molecular Imaging ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Imaging Probe ◽  
Molecular Imaging Probe

scholarly journals Development of molecular imaging probe targeted at Alzheimer’s disease pathology

2017 ◽  
Vol 150 (4) ◽  
pp. 172-176
Author(s):  
Nobuyuki Okamura ◽  
Ryuichi Harada ◽  
Shozo Furumoto ◽  
Tadaho Nakamura ◽  
Kazuhiko Yanai ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Imaging ◽  
Imaging Probe ◽  
Molecular Imaging Probe

scholarly journals Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers for In Situ Live-Cell Molecular Imaging of Dengue Virus Replication

2020 ◽  
Vol 21 (23) ◽  
pp. 9260
Author(s):  
Carla Bianca Luena Victorio ◽  
Wisna Novera ◽  
Jing Yang Tham ◽  
Satoru Watanabe ◽  
Subhash G. Vasudevan ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Dengue Virus ◽  
Antisense Oligonucleotides ◽  
Cell Penetrating Peptides ◽  
Live Cell ◽  
Imaging Probe ◽  
Non Invasive ◽  
Molecular Imaging Probe ◽  
Denv2 Infection

Current methods to detect and monitor pathogens in biological systems are largely limited by the tradeoffs between spatial context and temporal detail. A new generation of molecular tracking that provides both information simultaneously involves in situ detection coupled with non-invasive imaging. An example is antisense imaging that uses antisense oligonucleotide probes complementary to a target nucleotide sequence. In this study, we explored the potential of repurposing antisense oligonucleotides initially developed as antiviral therapeutics as molecular probes for imaging of viral infections in vitro and in vivo. We employed nuclease-resistant phosphorodiamidate synthetic oligonucleotides conjugated with cell-penetrating peptides (i.e., PPMOs) previously established as antivirals for dengue virus serotype-2 (DENV2). As proof of concept, and before further development for preclinical testing, we evaluated its validity as in situ molecular imaging probe for tracking cellular DENV2 infection using live-cell fluorescence imaging. Although the PPMO was designed to specifically target the DENV2 genome, it was unsuitable as in situ molecular imaging probe. This study details our evaluation of the PPMOs to assess specific and sensitive molecular imaging of DENV2 infection and tells a cautionary tale for those exploring antisense oligonucleotides as probes for non-invasive imaging and monitoring of pathogen infections in experimental animal models.

scholarly journals Iron oxide nanoparticulate system as a cornerstone in the effective delivery of Tc-99 m radionuclide: a potential molecular imaging probe for tumor diagnosis

2019 ◽  
Vol 27 (1) ◽  
pp. 49-58 ◽  
Author(s):  
Mohamed M. Swidan ◽  
Omnya M. Khowessah ◽  
Mohamed Abd El-Motaleb ◽  
Ahmed Abd El-Bary ◽  
Mohamed T. El-Kolaly ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Molecular Imaging ◽  
Tumor Diagnosis ◽  
Imaging Probe ◽  
Effective Delivery ◽  
Molecular Imaging Probe

scholarly journals Ex-vivo Imaging of Upper Tract Urothelial Carcinoma Using Novel pH Low Insertion Peptide (Variant 3), a Molecular Imaging Probe

Urology ◽  
2020 ◽  
Vol 139 ◽  
pp. 134-140 ◽  
Author(s):  
Joseph Brito ◽  
Borivoj Golijanin ◽  
Ohad Kott ◽  
Anna Moshnikova ◽  
Catrina Mueller-Leonhard ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Urothelial Carcinoma ◽  
Ex Vivo ◽  
Upper Tract Urothelial Carcinoma ◽  
Imaging Probe ◽  
Upper Tract ◽  
Molecular Imaging Probe ◽  
Ex Vivo Imaging
Sign in / Sign up

Export Citation Format

Share Document