Healthcare Applications of Nanoemulsions

2022 ◽  
pp. 517-537
Author(s):  
Dr.Sumira Malik ◽  
Shristi Kishore ◽  
Shradha A. Kumari ◽  
Anjali Kumari
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Pharmaceutical Formulations ◽  
Hydrophobic Core ◽  
Systemic Delivery ◽  
Healthcare Applications ◽  
Innovative Methods ◽  
Healthcare Needs ◽  
Parenteral Drug Delivery ◽  
Biomedical Field

The area of healthcare needs new innovative methods and tools for improvisation and to impart better efficiencies. Nanoemulsions are pharmaceutical formulations containing nanometre-sized particles used for controlled and systemic delivery of bioactive pharmaceuticals. Various advantageous properties of nanoemulsions such as the presence of hydrophobic core region, higher stability, and smaller size have made them useful to a large extent in the biomedical field. They have been employed in transdermal drug delivery, intranasal drug delivery, pulmonary drug delivery, parenteral drug delivery, and improvised delivery of hydrophobic drugs. This chapter aims to discuss various applications of nanoemulsions in healthcare including cosmetics, antimicrobials, vaccine delivery, targeted drug delivery, gene delivery, cancer therapy, and many more in detail.

Cellulose nanofibrils/chitosan based transdermal drug delivery vehicle for controlled release of ketorolac tromethamine

2017 ◽  
Vol 41 (24) ◽  
pp. 15312-15319 ◽  
Author(s):  
Gunjan Sarkar ◽  
Jonathan T. Orasugh ◽  
Nayan R. Saha ◽  
Indranil Roy ◽  
Amartya Bhattacharyya ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Surface Area ◽  
Transdermal Drug Delivery ◽  
High Surface ◽  
Cellulose Nanofibrils ◽  
High Surface Area ◽  
Ketorolac Tromethamine ◽  
Delivery Vehicle ◽  
Biomedical Field

Cellulose nanofibrils (CNFs) have attracted attention as a promising material in the biomedical field because of their outstanding properties such as hydrophilicity, biocompatibility, biodegradability, and high surface area.

Biodegradable 3D Printed Polymer Microneedles for Transdermal Drug Delivery

2018 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Danielle R. Berry ◽  
John C. Reagan ◽  
Ronald A. Smaldone ◽  
Jeremiah J. Gassensmith
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Transdermal Drug Delivery ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Modeling Software ◽  
Deposition Modeling ◽  
3D Printed ◽  
Microfabrication Technique ◽  
Mechanical Strengths

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.

Nanoemulsion: A brief review on development and application in Parenteral Drug Delivery

2018 ◽  
Vol 3 (2) ◽  
pp. 43-54 ◽  
Author(s):  
Tushar Hemant Nikam ◽  
Mahesh Pralhad Patil ◽  
Snehal Sunil Patil ◽  
Gautam P. Vadnere ◽  
Santram Lodhi
Keyword(s):  
Drug Delivery ◽  
Parenteral Drug Delivery ◽  
Parenteral Drug

Hydrogel-clay Nanocomposites as Carriers for Controlled Release

2020 ◽  
Vol 27 (6) ◽  
pp. 919-954 ◽  
Author(s):  
Raluca Ianchis ◽  
Claudia Mihaela Ninciuleanu ◽  
Ioana Catalina Gifu ◽  
Elvira Alexandrescu ◽  
Cristina Lavinia Nistor ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Hybrid Materials ◽  
Pharmaceutical Formulations ◽  
Tree Of Life ◽  
Present Review ◽  
Clay Nanocomposites ◽  
Delivery Platform ◽  
Complex Hybrid

The present review aims to summarize the research efforts undertaken in the last few years in the development and testing of hydrogel-clay nanocomposites proposed as carriers for controlled release of diverse drugs. Their advantages, disadvantages and different compositions of polymers/biopolymers with diverse types of clays, as well as their interactions are discussed. Illustrative examples of studies regarding hydrogel-clay nanocomposites are detailed in order to underline the progressive researches on hydrogel-clay-drug pharmaceutical formulations able to respond to a series of demands for the most diverse applications. Brief descriptions of the different techniques used for the characterization of the obtained complex hybrid materials such as: swelling, TGA, DSC, FTIR, XRD, mechanical, SEM, TEM and biology tests, are also included. Enlightened by the presented data, we can suppose that hydrogel-clay nanocomposites will still be a challenging subject of global assiduous researches. We can dare to dream to an efficient drug delivery platform for the treatment of multiple affection concomitantly, these being undoubtedly like ”a tree of life” bearing different kinds of fruits and leaves proper for human healing.

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