hze particles
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Author(s):  
L. Sajo-Bohus ◽  
J. A. López ◽  
M. Castro-Colin

Adverse effects of long-term exposure to galactic cosmic radiation (GCR) pose a non negligible obstacle for future space exploration programs; the high-LET-particle-rich environment has an adverse effect on human health. Concomitant to GCR we have as well solar particle radiation. Long term space exploration will rely on adequate and highly efficient shielding materials that will reduce exposure of both biosystems and electronic equipment to GCR and solar particles. The shield must attenuate efficiently heavy GCR ions, by breaking them up into less-damaging fragments and secondary radiation: biologically damaging energetic neutrons and highly charged and energetic HZE- particles. An approach to this problem is the development of shielding compounds. Shielding materials should address the conditions of different aspects of a given mission, e.g. time duration and travel path. The Monte Carlo method (GEANT4) is here employed to estimate the effects of a shielding material based on the recently developed Bi2O3-based compound (Cao et al., 2020). In the present study GEANT4 code is used to make estimations of attenuation of solar protons. The objective is to provide some insight about the effect of the new composite shield that has an intrinsic capability for dose reduction.



Life ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 264
Author(s):  
Vincenzo Zammuto ◽  
Maria G. Rizzo ◽  
Laura M. De Plano ◽  
Domenico Franco ◽  
Salvatore Guglielmino ◽  
...  

Extremophiles are optimal models in experimentally addressing questions about the effects of cosmic radiation on biological systems. The resistance to high charge energy (HZE) particles, and helium (He) ions and iron (Fe) ions (LET at 2.2 and 200 keV/µm, respectively, until 1000 Gy), of spores from two thermophiles, Bacillushorneckiae SBP3 and Bacilluslicheniformis T14, and two psychrotolerants, Bacillus sp. A34 and A43, was investigated. Spores survived He irradiation better, whereas they were more sensitive to Fe irradiation (until 500 Gy), with spores from thermophiles being more resistant to irradiations than psychrotolerants. The survived spores showed different germination kinetics, depending on the type/dose of irradiation and the germinant used. After exposure to He 1000 Gy, D-glucose increased the lag time of thermophilic spores and induced germination of psychrotolerants, whereas L-alanine and L-valine increased the germination efficiency, except alanine for A43. FTIR spectra showed important modifications to the structural components of spores after Fe irradiation at 250 Gy, which could explain the block in spore germination, whereas minor changes were observed after He radiation that could be related to the increased permeability of the inner membranes and alterations of receptor complex structures. Our results give new insights on HZE resistance of extremophiles that are useful in different contexts, including astrobiology.



2018 ◽  
Vol 19 (10) ◽  
pp. 3078 ◽  
Author(s):  
Giulia Zanni ◽  
Hannah Deutsch ◽  
Phillip Rivera ◽  
Hung-Ying Shih ◽  
Junie LeBlanc ◽  
...  

High-charge and -energy (HZE) particles comprise space radiation and they pose a challenge to astronauts on deep space missions. While exposure to most HZE particles decreases neurogenesis in the hippocampus—a brain structure important in memory—prior work suggests that 12C does not. However, much about 12C’s influence on neurogenesis remains unknown, including the time course of its impact on neurogenesis. To address this knowledge gap, male mice (9–11 weeks of age) were exposed to whole-body 12C irradiation 100 cGy (IRR; 1000 MeV/n; 8 kEV/µm) or Sham treatment. To birthdate dividing cells, mice received BrdU i.p. 22 h post-irradiation and brains were harvested 2 h (Short-Term) or three months (Long-Term) later for stereological analysis indices of dentate gyrus neurogenesis. For the Short-Term time point, IRR mice had fewer Ki67, BrdU, and doublecortin (DCX) immunoreactive (+) cells versus Sham mice, indicating decreased proliferation (Ki67, BrdU) and immature neurons (DCX). For the Long-Term time point, IRR and Sham mice had similar Ki67+ and DCX+ cell numbers, suggesting restoration of proliferation and immature neurons 3 months post-12C irradiation. IRR mice had fewer surviving BrdU+ cells versus Sham mice, suggesting decreased cell survival, but there was no difference in BrdU+ cell survival rate when compared within treatment and across time point. These data underscore the ability of neurogenesis in the mouse brain to recover from the detrimental effect of 12C exposure.



2018 ◽  
Vol 16 ◽  
pp. 84-92 ◽  
Author(s):  
Bernard M. Rabin ◽  
Kirsty L. Carrihill-Knoll ◽  
Marshall G. Miller ◽  
Barbara Shukitt-Hale


PLoS ONE ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. e0153998 ◽  
Author(s):  
Eliedonna Cacao ◽  
Megumi Hada ◽  
Premkumar B. Saganti ◽  
Kerry A. George ◽  
Francis A. Cucinotta






2011 ◽  
Vol 48 (2) ◽  
pp. 370-377 ◽  
Author(s):  
Bernard M. Rabin ◽  
Kirsty L. Carrihill-Knoll ◽  
Barbara Shukitt-Hale


2010 ◽  
Vol 174 (6a) ◽  
pp. 669-678 ◽  
Author(s):  
Martha C. Sanchez ◽  
Gregory A. Nelson ◽  
Lora M. Green


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