Dynamic Transitions between Neural States Are Associated with Flexible Task Switching during a Memory Task

Flexible behavior requires switching between different task conditions. It is known that such task switching is associated with costs in terms of slowed RT, reduced accuracy, or both. The neural correlates of task switching have usually been studied by requiring participants to switch between distinct task conditions that recruit different brain networks. Here, we investigated the transition of neural states underlying switching between two opposite memory-related processes (i.e., memory retrieval and memory suppression) in a memory task. We investigated 26 healthy participants who performed a think/no-think task while being in the fMRI scanner. Behaviorally, we show that it was more difficult for participants to suppress unwanted memories when a no-think was preceded by a think trial instead of another no-think trial. Neurally, we demonstrate that think–no-think switches were associated with an increase in control-related and a decrease in memory-related brain activity. Neural representations of task condition, assessed by decoding accuracy, were lower immediately after task switching compared with the nonswitch transitions, suggesting a switch-induced delay in the neural transition toward the required task condition. This suggestion is corroborated by an association between condition-specific representational strength and condition-specific performance in switch trials. Taken together, we provided neural evidence from the time-resolved decoding approach to support the notion that carryover of the previous task set activation is associated with the switching cost, leading to less successful memory suppression.

Correlation analysis to investigate unconscious mental processes: A critical appraisal and mini-tutorial

As a method to investigate the scope of unconscious mental processes, researchers frequently obtain concurrent measures of task performance and stimulus awareness across participants. Even though both measures might be significantly greater than zero, the correlation between them might not, encouraging the inference that an unconscious process drives task performance. We highlight the pitfalls of this null-correlation approach and provide a mini-tutorial on ways to avoid them. As reference, we use a recent study by Salvador, Berkovitch, Vinckier, Cohen, Naccache, Dehaene, and Gaillard (2018) reporting a non-significant correlation between the extent to which memory was suppressed by a Think/No-Think cue and an index of cue awareness. In the Null Hypothesis Significance Testing (NHST) framework, it is inappropriate to interpret failure to reject the null hypothesis (i.e., correlation = 0) as evidence for the null. Furthermore, psychological measures are often unreliable, which can dramatically attenuate the size of observed correlations. A Bayesian approach can circumvent both problems and compare the extent to which the data provide evidence for the null versus the alternative hypothesis (i.e., correlation > 0), while considering the usually low reliabilities of the variables. Applied to Salvador et al.’s data, this approach indicates no to moderate support for the claimed unconscious nature of participants’ memory-suppression performance—depending on the model of the alternative hypothesis. Hence, more reliable data are needed. When analyzing correlational data, we recommend researchers to employ the Bayesian methods developed here (and made freely available as R scripts), rather than standard NHST methods, to take account of unreliability.

Sleep reactivation did not boost suppression-induced forgetting

Sleep's role in memory consolidation is widely acknowledged, but its role in weakening memories is still debated. Memory weakening is evolutionary beneficial and makes an integral contribution to cognition. We sought evidence on whether sleep-based memory reactivation can facilitate memory suppression. Participants learned pairs of associable words (e.g., DIET–CREAM) and were then exposed to hint words (e.g., DIET) and instructed to either recall (“think”) or suppress (“no-think”) the corresponding target words (e.g., CREAM). As expected, suppression impaired retention when tested immediately after a 90-min nap. To test if reactivation could selectively enhance memory suppression during sleep, we unobtrusively presented one of two sounds conveying suppression instructions during sleep, followed by hint words. Results showed that targeted memory reactivation did not enhance suppression-induced forgetting. Although not predicted, post-hoc analyses revealed that sleep cues strengthened memory, but only for suppressed pairs that were weakly encoded before sleep. The results leave open the question of whether memory suppression can be augmented during sleep, but suggest strategies for future studies manipulating memory suppression during sleep. Additionally, our findings support the notion that sleep reactivation is particularly beneficial for weakly encoded information, which may be prioritized for consolidation.

Long-term modulation of cardiac activity induced by inhibitory control over emotional memories

Efforts to exclude past experiences from conscious awareness can lead to forgetting. Memory suppression is central to affective disorders, but we still do not really know whether emotions, including their physiological causes, are also impacted by this process in normal functioning individuals. In two studies, we measured the after-effects of suppressing negative memories on cardiac response in healthy participants. Results of Study 1 revealed that efficient control of memories was associated with long-term inhibition of the cardiac deceleration that is normally induced by disgusting stimuli. Attempts to suppress sad memories, by contrast, aggravated the cardiac response, an effect that was closely related to the inability to forget this specific material. In Study 2, electroencephalography revealed a reduction in power in the theta (3–8 Hz), alpha (8–12 Hz) and low-beta (13–20 Hz) bands during the suppression of unwanted memories, compared with their voluntary recall. Interestingly, however, the reduction of power in the theta frequency band during memory control was related to a subsequent inhibition of the cardiac response. These results provide a neurophysiological basis for the influence of memory control mechanisms on the cardiac system, opening up new avenues and questions for treating intrusive memories using motivated forgetting.

Trait Mindfulness and Emotion Regulation upon Autobiographical Memory Retrieval during Depression Remission

Objectives Depression is associated with both emotion dysregulation upon retrieval of autobiographical memories and low trait mindfulness. The present study raised the question of whether these processes are related to each other and whether they may reflect a cognitive-affective vulnerability in individuals at risk of depression. The study examined emotion regulation in response to involuntary and voluntary autobiographical memories during depression remission and explored how trait mindfulness relates to such emotion regulation. Methods The study employed a naturalistic design in which individuals with remitted depression (n = 35) and individuals with no history of depression (n = 32) completed a trait mindfulness measure and a structured memory diary where they rated state use of five emotion regulation strategies upon involuntary and voluntary autobiographical memory retrieval. Results Individuals with remitted depression reported heightened brooding in response to autobiographical memories when memory retrieval occurred involuntarily, and trait mindfulness was low. Depression remission and higher trait mindfulness were independently associated with greater cognitive reappraisal efforts upon involuntary retrieval of autobiographical memories. Higher trait mindfulness predicted less memory suppression, irrespective of depression history and memory retrieval mode. Conclusions The findings suggest a vulnerability in emotional processing of autobiographical memories during depression remission that is dependent on mindfulness skill level and how memories come to mind.