Novel Copper Nanoparticles Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates Coated Stents: Viability Study for Coronary Vascular Cells and Aneurysms Treatments

Continuous delayed endothelium regeneration and continues thrombosis development designate a task for coronary artery stent rehabilitation. To progress the direct vascular cell behavior, aneurysms treatments and compatibility of cardiovascular implants novel copper intercalated polyurethane heparin/poly-L-lysine chelates treated stent has established in this report. The functional group modifications, structural characteristics, and stability of the chelates have investigated for polyurethane heparin: poly-L-lysine, copper intercalated polyurethane heparin/poly-L-lysine coated stents. The FTIR results showed the copper intercalation at 446 cmr and the Cu 2s peak at 932 eV from XPS also indicated that the successful coating of copper, polyurethane heparin, poly-L-lysine. The relative surface geomorphology of the chelates displayed the uniform Cu coating consisting of multilayer poly-L-lysine on the substrate. The stability and biocompatibility studies indicated the significantly enhanced performance with clot the APTT and TT periods as clotting and cell proliferation assessments. This type of composite proposes a stage on a stent external area for discerning track of vascular cell performance and aneurysms treatments with low side effects.

The geomorphology of debris-covered Ponkar Glacier, Nepal

<p>Understanding the evolution of debris-covered glaciers in High Mountain Asia is important for making informed projections of climate change impacts and associated water security and hazard-related issues.  Here we describe the geomorphology of Ponkar Glacier, a debris-covered glacier in Nepal using high-resolution images from 2017 and 2019 based on Unmanned Aerial Vehicle (UAV) flights collected over the glacier and surrounding area in the field. These are used to describe the overall glacier morphology and its ice-surface geomorphology.  The key features of the glacier and its ice-surface morphology are described, including size and extent of tributary glaciers; changes in % of debris cover, lakes, ponds, ice cliffs, crevasses, and vegetation. Geomorphological mapping is used to describe the proglacial geomorphology, outwash plains and proglacial streams, the development of new ice-marginal ponds and changes in vegetation. We use these data to make inferences about the processes of moraine formation in this area. </p>

Geophysical evidence for a large Holocene ice marginal moraine of Skeiðarárjökull, SE Iceland

<p>The sedimentary record of Icelandic ice-contact environments provides valuable information about glacier margin dynamics and position, relative sea-level and the geomorphic processes driving proglacial environments. This important archive has been little exploited, however, with most glacier and sea level reconstructions based on limited sedimentary exposures and surface geomorphic evidence. Although geophysical surveys of Icelandic sandur have been conducted, they have often been of limited spatial scale and focused on specific landforms. Here, we report an extensive (42 km of data) detailed low-frequency (40 and 100 MHz) ground-penetrating radar (GPR) survey of the Sandgigúr moraine complex, SE Iceland, which transforms our understanding of this landform, with implications for the Holocene history of Skeiðarársandur and SE Iceland.</p><p>The Sandgigúr moraines are located on Skeiðarársandur, SE Iceland, down-sandur of large Little Ice Age-moraines of Skeiðarárjökull. They have a relatively subtle surface geomorphic expression (typically 125 m wide and 7 m high), and knowledge of their formation is limited, with no dating control on their age or detailed geomorphic or sedimentological investigations.  GPR investigations reveal a much larger (60 m high and 1200 m wide) and extensive buried moraine complex than that suggested by surface morphology, suggesting that the moraine was a major Holocene ice margin of Skeiðarárjökull.</p><p>GPR reflections interpreted as large progradational foresets (up to 20 m in height) beneath the morainic structure are consistent with a sub-aqueous depositional environment before moraine formation, providing potential controls on former sea-level.  The GPR data also provide information on the internal structure of the moraine, with evidence for glacitectonism within the proximal side of the moraine, multiphase moraine formation, and possible buried ice at depth. A 30-40 m thick package of down-sandur dipping GPR reflections drape the leeside of the moraine, evidencing glaciofluvial deposition during and after moraine development. Potential moraine breaches, possibly caused by glaciofluvial (e.g. jökulhlaup) events, are also apparent within the GPR data and the surface geomorphology.</p><p>We combine GPR-derived subsurface architecture with the current surface morphology to develop a conceptual model detailing the geomorphic evolution of the moraines and surrounding region, from pre-moraine morphology, to their formation and breaching, resulting in the subsequent present-day morphology. These results provide new insights into the Holocene to present-day evolution of Skeiðarársandur and Skeiðarárjökull, with implications for reconstructions of the Holocene environmental history of SE Iceland.</p>

First quantitative evidences of ghost-rock karstification controlling regional karst geometry

<p>Although more and more processes are discussed and discovered on the genesis and evolution of cave systems, the tiered karsts are often explained by a control of the base level evolution. In this classical model, the horizontal galleries are explained by a stability of the base level elevation. To the contrary, the shafts and network segments with steep slopes are related to incision periods with a base level lowering.</p><p>We use Terrestrial Cosmogenic Nuclide Geochronology to estimate burial ages of alluvium trapped in several caves of the Larzac plateau in Southern France. All the samples are collected in horizontal cave levels, sometimes located between steeper segments. Some caves are opened in river gorge walls, while others are located below the Larzac plateau not farther than 5km away from the river gorges.</p><p>The burial ages for the caves opening in the gorges are consistent with the incision rates given for the area and could be interpreted using the classical model. However, the cave within the plateau show a horizontal level with alluvium deposited 200m above the caves in the gorge with the same burial ages (~1 Myr). Since then, new shafts have been opened without alluvium and are hydrologically connected to the river by deeper[jfr1]  hypogenic galleries. The cave morphologies and the geochronological data suggest that the classical model fails to explain the horizontal levels in cave below the plateau. We postulate that the geometry of the caves in these limestone and dolomite plateaus are related to a previous period of ghost-rock and alteration roots formations. Without the opening of an efficient connection between this primokarst and the valley, no alluvium can flow through the cave. Therefore, we think that our burial ages constrain the emptying of the ghost-rocks leading to the genesis of the cave where water and possibly alluvium can flow through. Furthermore, these new finding explain why the horizontal levels in the caves are not clearly related to horizontal markers in the surface geomorphology and why large shafts (>100m) exist in the area without evidences of long periods of base level stability followed by large drop of the regional base level.</p><div> <div> <div> </div> </div> </div>

Four years after the catastrophe, are educational institutions in the Region of Murcia in Spain prepared for the next seismic disaster?

Un terremoto de magnitud 6.0 o más está esperado en la falla Alhama de Murcia, la más activa de la región de Murcia, localizada en el sureste de España. El 11 de Mayo de 2011, en un intervalo de una hora y 42 minutos, dos terremotos de magnitud 4.5 y 5.1 sacuden las ciudades deLorca y Totana, resultando en nueve fatalidades y 330 heridos. Sin embargo, cuatro años después de la catástrofe, estas ciudades no parecen estar preparadas a hacer frente a un terremoto de magnitud moderada. Todos los factores están combinados para terminar en una catástrofe es decir, una superficie geomorfológica que favorece los efectos de sitio, construcciones que no cumplen con las normas parasísmicas y la falta de conocimiento sobre el riesgo sísmico por parte de la población. Este estudio propone unanálisis del nivel de vulnerabilidad de los centros educacionales contra el riesgo sísmico en Lorca y Totana basado en la creación de un índice de vulnerabilidad considerando los factores de riesgo sociales y estructurales. Además propone una serie de medidas de mitigación para hacer frenteal próximo desastre sísmico mayor. A magnitude 6.0 or more earthquake is expected on the Alhama de Murcia fault, the most active in the area of Murcia, located in the south-eastern Spain. On May 11th 2011, within one hour and 42 minutes period, a magnitude 4.5 and a magnitude 5.1 earthquakes shake the towns of Lorca and Totana, killing nine people and injuring 330. However, four years after the catastrophe, these towns do not seem to be prepared to face a moderate earthquake. All elements are gathered to result in a disaster, i.e. a surface geomorphology conducive for site effects, constructions which do not comply the earthquake-resistant requirements and a lack of knowledge from the population about the seismic risk. This report proposes an analysis of the level of vulnerability of educational institutions against the seismic risk in Lorca and Totana based on creating a vulnerability index which considers social and structural risk factors. As well as a series of mitigation measures proposals to face the next major seismic disaster.

Artificial Aquatic Ecosystems

As humans increasingly alter the surface geomorphology of the Earth, a multitude of artificial aquatic systems have appeared, both deliberately and accidentally. Human modifications to the hydroscape range from alteration of existing waterbodies to construction of new ones. The extent of these systems makes them important and dynamic components of modern landscapes, but their condition and provisioning of ecosystem services by these systems are underexplored, and likely underestimated. Instead of accepting that artificial ecosystems have intrinsically low values, environmental scientists should determine what combination of factors, including setting, planning and construction, subsequent management and policy, and time, impact the condition of these systems. Scientists, social scientists, and policymakers should more thoroughly evaluate whether current study and management of artificial aquatic systems is based on the actual ecological condition of these systems, or judged differently, due to artificiality, and consider resultant possible changes in goals for these systems. The emerging recognition and study of artificial aquatic systems presents an exciting and important opportunity for science and society.

GEOMORPHIC CONSTRAINS ON THE EVOLUTION OF THE AGGITIS RIVER BASIN NORTHERN GREECE (A PRELIMINARY REPORT)

In this paper we discuss the landscape evolution of the Aggitis River basin by correlating the morphological characteristics of the Maaras Cave (Aggitis River spring) with the main geomorphological features of the Aggitis fluvial valley. We combine the various morphological features that are hidden inside the Maaras Cave with the surface geomorphology of the river valley in order to trace the imprint of the different evolutionary stages on the landscape. Also, we provide a relative chronological framework for the evolution of the area. The 3D survey of the Maaras Cave shows that the roof of the cave is looping-like shaped in contrast to the floor of the cave that shows low slopes and holds thick clastic sediment deposits. Furthermore, the geomorphological mapping of the Aggitis River valley shows two prominent windgaps at the southern part of the basin that formed as the result of river capture. Our results suggest that the Aggitis River basin suffered four major evolutionary stages from the Neogene until the Quaternary.