A registry review of 2532 catheter ablations for atrial fibrillation using active thermal protection

Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): Dr Leung has received research support from Attune Medical (Chicago, IL). Dr Gallagher has received research funding from Attune Medical (Chicago, IL). Background Thermal injury to the oesophagus causes a spectrum of adverse effects after ablation for atrial fibrillation (AF); at the most severe end, atrio-oesophageal fistula carries a high mortality rate. Controlled active thermal protection in the oesophagus during ablation is the most promising method of oesophageal protection. Randomized evidence from the IMPACT trial (NCT03819946) showed an 83.4% reduction in endoscopically detected oesophageal lesions compared to standard care when an oesophageal temperature control device was used to control the local temperature. The IMPACT patients who were randomized to the use of the device had no adverse event related to its use. Real world registry data on applications of this device have not previously been available. Purpose To determine the safety of an oesophageal temperature control device by review of real-world registry data on its clinical use and any reported device-related adverse events. Methods We reviewed the following databases for any reported oesophageal temperature control device-related complications: The United States Food and Drug Administration (FDA) Manufacturer and User Facility Device Experience (MAUDE), FDA Medical and Radiation Emitting Device Recalls, the Medicines and Healthcare products Regulatory Agency (MHRA) Medical Device Alerts and SwissMedic records of Field Safety Corrective Actions (FSCA). An internal registry (post-marketing follow up) database maintained by the manufacturer of the device was used to quantify the number used for each indication. Reported events were reviewed and catalogued for description and identification of any events related to its use in the cardiac electrophysiology lab. The IMPACT study patients were reviewed for any device-related events. Results Of the 13, 284 oesophageal temperature control devices used, 2532 were recorded as having been used for the purpose of oesophageal protection during catheter ablation for AF. A total of 5 events associated with the device were identified, all from the MAUDE database. Three were from 2017, one from 2018, and one from 2019. All involved its use in critical care or trauma patients and were related to user error or contraindicated patient selection; none resulted in serious harm to the patient. No adverse events occurred related to its use in the cardiac electrophysiology lab. No case of clinically significant oesophageal injury was reported in a patient who had been protected by the oesophageal temperature control device. Conclusions Real world registry data has shown no adverse events reported to date in over 2500 uses of an oesophageal temperature control device in the cardiac electrophysiology lab, for the purpose of active thermal protection. This data supports the randomized trial evidence of its clinical effectiveness. Abstract Figure. Oesophageal active thermal protection

Research on a Temperature Control Device for Seawater Hydraulic Systems Based on a Natural Gas Hydrate Core Sample Pressure-Retaining and Transfer Device

In the study of natural gas hydrates, the maintenance of the low-temperature and high-pressure state of the core sample under in situ conditions is highly important for cutting, transferring, and subsequent analysis. The pressure maintenance and temperature control device (PMTCD) for natural gas hydrate core samples described in this paper is a subsystem of the pressure-retaining and transfer device. The device consists of a water tank, seawater chillers, a plunger pump and a thermoelectrical refrigeration device. The device cools the seawater to 2 °C, and then pressurizes it to inject it into the sample cylinder. Due to the inevitable heat generated by the pressurization and heat exchange with environment, there is a thermoelectrical refrigeration device to compensate for temperature rise. Finally, the seawater temperature entering the sample cylinder is no higher than 3 °C, effectively preventing the decomposition and deterioration of the natural gas hydrate core in the sample cylinder. In this paper, the temperature increase of the device and its compensation capacity are analyzed in detail on the basis of calculation and simulation. On the basis of testing with the device, it is verified that even at the ambient temperature, the water temperature can still be maintained at 3 °C.

PID-based temperature control device for electric kettle

A normal electric kettle usually is intended to boil water until boiling point and cannot be controlled. Most of the kettle does not provide the temperature display for user to track the current temperature reading. Thus, this project is inspired from the shortcoming of most kettles that are sold at the market. By using Arduino microcontroller, a device is developed to control water temperature inside electric kettle. To provide automated temperature control, PID controller is chosen since it can provides precise water temperature control with less fluctuation. The device is also equipped with the display of the current water temperature and desired temperature. The device is tested to an electric kettle and the performance of PID controller in controlling water temperature is compared to on-off controller. An analysis is performed based on the amount of fluctuation with respect to desired temperature to verify the efficacy of the designed circuit and controller. It is found that the developed device and PID controller are capable to control the water temperature inside kettle based on the desired temperature set by user with less amount of fluctuation