Symptomatic pancreatic body endometrial cyst requiring en bloc distal pancreatectomy

Pancreatic endometriosis is an extremely rare condition, with only a few cases described in the literature. Definitive diagnosis is often difficult to elucidate and will almost always require biopsy or surgical resection. We present a case of a female in her early thirties with a well-known history of widespread endometriosis presenting with vague epigastric pain. CT imaging showed an 11 cm well-circumscribed simple-appearing cyst in the lessor sac. Its origin could not be determined preoperatively but it appeared to involve the parenchyma of the body of the pancreas. Due to the associated pain and indeterminate nature, subtotal surgical resection of the extrapancreatic cyst was performed with the intrapancreatic cyst being managed by a cystogastrostomy to the adjacent stomach in a planned pancreas-sparing procedure following intraoperative confirmation it was arising within the pancreas. Pathological evaluation of the resected cyst confirmed it to be an endometrial cyst. The cystogastrostomy anastomosis subsequently obstructed a few weeks postoperatively and symptoms recurred from cyst enlargement. Redo robotic resection with resection of the remnant cyst, cystogastrostomy and en bloc spleen-preserving distal pancreatectomy was performed. The patient had an uneventful recovery. She has had no recurrence of cyst or symptoms since. A procedure video is included in the report.

Chocolate Endometrial Cyst: A Case Report

Introduction: Chocolate cysts are noncancerous, fluid-filled cysts that typically form deep within the ovaries. They get their name from their brown, tar-like appearance, looking something like melted chocolate. They're also called ovarian endometriomas [1]. Case Presentation: The authors report an unusual case of chocolate endometrial cyst. During history collection it found that patient develop a severe pain at midnight, after all the investigation the ultrasonography they diagnosed probe tenderness in RIF. Significant free fluid in abdominal cavity. Well circumscribed mix echoic mass lesion seen in hypogastric region more in right paraumbilical region with eccentrically placed small tubular structure visualized. Mass lesion of size 110mm×110mm. USG guided tapping done, the ascitic fluid smears shows fresh RBC’s and other blood cells entrapped in fibrin clot. Background is haemorrhagic and malignant cells are absent. Abdominal surgery was done and chocolate cyst was removed and sent to histopathology for further investigations. Conclusion: In this study, author mainly focus on expert surgical management and excellent nursing care which leads to fast recovery of patient. After conversation with patient her response was positive and after nursing management and treatment she was discharged without any postoperative complications and satisfaction of recovery.

Surgical Techniques to Reduce the Diminished Ovarian Reserve Risk of Endometrial Cyst

AIM: The objective of the study was to report the endometriosis case and surgical technique to reduce the diminished ovarian reserve risk. CASE PRESENTATION: A 32-year-old woman was presented with the lower abdominal pain since 1 year ago, intermittent, and got worse during menstruation. The mobile cystic mass was palpable on the abdomen without pain during palpation. Vaginal examination showed mobile and smooth surface cystic mass was palpable, the upper pole was three fingers below the umbilicus, and lower pole was in line with pubic symphysis. Transvaginal ultrasonography (TVUS) showed uterus and right ovary enlargement; and unilocular cyst with homogenous echo pattern. There was a marked increase in CA-125. Based on International Tumor Analysis, the tumor was classified as B1 unilocular cyst and the malignancy risk index was 600. The patient was diagnosed with endometriosis and laparotomy cystectomy was performed. CONCLUSION: Patient was diagnosed with endometrial cyst and laparotomy cystectomy was performed as treatment. Ovarian cystectomy in infertile women was shown to have comparable ovarian reserve (OR), reduced pain symptoms, and increased conception among infertile patients.

Contrast-enhanced ultrasound evaluation of a refractory ovarian endometrial cyst and ultrasound-guided aspiration sclerotherapy using urokinase and lauromacrogol

Endometriosis is one of the most common diseases that happen in reproductive women. The main symptoms include ovarian endometrial cyst, pelvic pain, and so on. We report a case of a 23-year-old woman with a refractory long-course ovarian endometrial cyst (OEC). The patient was previously identified to have a hypoechoic mass sized 9.7 cm in diameter on ultrasound (US) in the right ovary and was tentatively diagnosed as OEC in another tertiary hospital, who was then subjected to US-guided cyst sclerotherapy while the procedure was failed since only a very small amount of viscous and sticky fluid can be aspirated. The patient was then referred to our hospital for further treatment. Pretreat contrast-enhanced ultrasound (CEUS) showed non-enhancement of the mass with a thin cyst wall and a cyst-in-cyst pattern was observed. The possibility of ovarian malignancy was ruled out and the initial diagnosis of OEC was confirmed. The patient was then subjected to US-guided cyst sclerotherapy with lauromacrogol. The interventional procedure was eventful that no fluid was aspirated as what happened in the previous hospital. Thus urokinase was used to dissolve the old, viscious and sticky blood and finally, all the fluid was aspirated. The total consumption of urokinase was 60,000 U. Then lauromacrogol as a sclerosant was injected into the cyst cavity and the cyst wall was flushed repeatedly with lauromacrogol until the aspirated fluid became light red. Finally, 20 mL lauromacrogol was reserved in the cyst and the interventional procedure cost 2 hours The post-procedure course was uneventful without any discomfort, and the volume reduction rate of the cyst was 54%at 3-month follow-up. The visual analogue scale for the pain decreased from 4 before treatment to 1 after treatment, indicating a successful and effective outcome for the refractory long-course OEC.

Novel clinical and morphological predictors of malignancy in patients with ovarian endometrioid cysts

Introduction. Endometriosis is an endless source of scientific investigations, but still the mechanisms of malignant transformation of ovarian endometriosis remain to be understood. Patients and methods. This study was conducted on surgical specimens isolated from ovarian endometri-oid cysts (OEC) and the endometriosis-associated ovarian tumors obtained after surgical operation from 117 patients. The normal level of serum CA 125 was assumed to be up to 35 IU/ml. Immunohistochemical study of MCK, CK7, CK20, CK 8/18, Calretinin, EMA, Ki67, CEA, Vimentin, Inhibin, WT1, p53, ARID1A (BAF250a), CA 125 antibodies was performed. Results. The results revealed a direct correlation between the level of serum CA 125 and the WT1 expression in the OEC epithelium (Pearson r=0.84, p<0.0001) and between the level of serum CA 125 and the p53 expression (Pearson r=0.81, p<0.0001). A striking direct correlation was found when studying the relation-ship between WT1 and p53 expression in OEC epithelium (Pearson r=0.79, p<0.0001). Conclusion. This research delineated the changes in OEC epithelium, which were similar to the serous epithelial type and associated with an extensive rise in the serum biomarker CA 125 level, which could be indicative of the early neoplastic transformation of OEC. Keywords: CA 125, WT1, p53, ovarian endometrial cyst, ARID1A, malignant transformation