Towards on-chip real-time classification of extra-cellular neural recordings

On-line classification of neural recordings can be extremely useful in brain-machine interface, prosthetic applications or therapeutic intervention. In this work we present a feasibility study for developing compact low-power VLSI systems able to classify neural recordings in real-time, using spike-based neuromorphic circuits. We developed a framework for classifying extra-cellular recordings made in rat auditory cortex in response to different auditory stimuli and porting the classification algorithm onto a spiking multi-neuron VLSI chip with programmable synaptic weights. We present recording methods and software classification algorithms; we demonstrate real-time classification in hardware and quantify the system performance; finally, we identify the potential sources of problems in developing such types of systems and propose strategies for overcoming them.

TE Hub: A community-oriented space for sharing and connecting tools, data, resources, and methods for transposable element annotation

Transposable elements (TEs) play powerful and varied evolutionary and functional roles, and are widespread in most eukaryotic genomes. Research into their unique biology has driven the creation of a large collection of databases, software, classification systems, and annotation guidelines. The diversity of available TE-related methods and resources raises compatibility concerns and can be overwhelming to researchers and communicators seeking straightforward guidance or materials. To address these challenges, we have initiated a new resource, TE Hub, that provides a space where members of the TE community can collaborate to document and create resources and methods. The space consists of (1) a website organized with an open wiki framework, https://tehub.org, (2) a conversation framework via a Twitter account and a Slack channel, and (3) bi-monthly Hub Update video chats on the platform’s development. In addition to serving as a centralized repository and communication platform, TE Hub lays the foundation for improved integration, standardization, and effectiveness of diverse tools and protocols. We invite the TE community, both novices and experts in TE identification and analysis, to join us in expanding our community-oriented resource.

C5.0 Algorithm Implementation on Web-Based Software and Usability Evaluation

AbstrakPerangkat lunak merupakan alat bantu yang memudahkan pengguna dalam pengolahan data dengan cepat dan tepat. Para pengambil keputusan membutuhkan alternatif perangkat lunak yang dapat digunakan setiap saat dengan teknik klasifikasi data algoritma C5.0 sesuai kriteria yang diinginkan. Namun perangkat lunak yang ada umumnya terdiri dari sejumlah teknik dan belum dapat digunakan secara online. Sebagai salah satu algoritma klasifikasi yang popular dalam ilmu data mining, C5.0 dapat memberikan hasil yang lebih baik. Penelitian bertujuan untuk membangun perangkat lunak yang dapat melakukan klasifikasi data menggunakan algoritma C5.0 berbasis web. Perangkat lunak dapat digunakan oleh siapa saja, terutama para pengambil keputusan. Penelitian ini juga dilengkapi dengan pengujian perangkat lunak usability sebelum digunakan. Hasil pengujian memperlihatkan bahwa perangkat lunak yang dibangun dapat diterima dengan nilai usability 76,892% dan berada pada predikat Baik. Diharapkan melalui penelitian ini, dapat memberikan alternatif perangkat lunak yang mampu menyelesaikan masalah klasifikasi menggunakan algoritma C5.0.Kata kunci: perangkat lunak, klasifikasi, algoritma c5.0, usability AbstractSoftware is a tool that makes it easy for users to process data quickly and precisely. Decision makers need an alternative software that can be used at any time with the C5.0 algorithm data classification technique according to the desired criteria. However, the existing software generally consists of a number of techniques and cannot be used online. As one of the popular classification algorithms in data mining science, C5.0 can provide better results. This study aims to build software that can classify data using the web-based C5.0 algorithm. Software can be used by anyone, especially decision makers. This research is also complemented by testing Usability software before used. The test results showed that the software built can be accepted with a Usability value of 76.892% and is in the Good predicate. It is hoped that through this research, it can provide alternative software that is able to solve classification problems using the C5.0 algorithm.Keywords: software, classification, c5.0 algorithm, usability

Improvement of detectics through electronic resources in the educational process

This article is about analysis of modern educational electron publications showed that they have a complex structure and are autonomous to cassification. On the basis of the classification of electronic educational publications are general methods of both educational and electronic and software classification

SUN-137 Clonal Status of Multigland Disease Primary Hyperparathyroidism

Primary hyperparathyroidism (PHPT) is a common endocrine disorder that arises due to single or multiple parathyroid gland disease (MGD). The molecular mechanism(s) of parathyroid neoplasia are incompletely understood and both monoclonal (mono-X) and polyclonal (poly-X) parathyroid tumors have been described using methylation-sensitive PCR of X-linked Human Androgen Receptor (HUMARA) alleles. Our previous investigations of parathyroid tumor clonal status has shown that poly-X tumors are common and are associated with MGD in patients with non-familial PHPT (Shi et al. 2014 & 2018). This work examined the clonal status of the dominant gland and the clonal relationship of multiple tumors from the same patient has not been examined. The goal of the current study was to determine the clonal relationship of parathyroid tumors from PHPT patients with MGD. Banked parathyroid tissues from twenty-nine PHPT patients with MGD were examined in this study. Clonal status (mono-X vs poly-X) of multiple abnormal parathyroid glands from each patient was determined using a modification of the HUMARA assay used in our prior work. Briefly, methylation-sensitive PCR of HUMARA alleles was performed followed by fragment analysis using Capillary-Electrophoresis performed. Raw fragment sizing data analyzed using Peak Scanner software. Classification of samples as either mon-X or poly-X was made as described in (Shattuck et al.) Of 29 PHPT patients with MGD, 13 (45%) had pure mono-X, 5 (17%) had pure poly-X, and 11 (38%) had a mixture of mono-X and poly-X tumors. Five of 29 patients had three or more abnormal glands evaluated: 3 had mixture of poly-X and mono-X, 2 had pure mono-X tumors, and none were pure polyclonal-X. Eighteen (62%) out of 29 patients had paired upper or lower double adenomas. Of these, 9 (50%) were pure mono-X, 4 were pure poly-X, and 5 were mixed mono-X/poly-X. In 2 patients with multiple mono-X tumors, allele distribution was not the same in different abnormal glands. Our previous work has demonstrated that among patients with non-familial PHPT, poly-X parathyroid tumors are common and are associated with MGD. Our new data extend these findings to show that the clonal relationship between multiple parathyroid tumors from the same patient is complex and may reflect the emergence of single or multiple tumors from a background of parathyroid hyperplasia, or other mechanism(s). Future studies to explore the mechanisms behind these apparent clonal relationships are warranted and ongoing. Reference: (1) Shi et al., PNAS 2014, 201319742. (2) Shi et al., Surgery 2018, 9-14. (3) Shattuck. N Engl J Med 2005, 2406-12.

Process for the identification of land use in environment preservation areas in the municipality of São José dos Campos – SP

The present article deals with the urbanization process in the Paraíba do Sul river basin, covering social occupation under consideration of the legal provisions for areas surrounding water resources. The study has the purpose of assessing the Environment Preservation Area, called APA Banhado, in the city of São José dos Campos, a municipality belonging to the Metropolitan Region of the Paraíba Valley and the Northern Sea Shore (RMVPLN) in the state of São Paulo, Brazil. The research carried out made use of materials and information collected from aerial images obtained from remote sensing databases maintained by public offices, and the provisions of the APA Banhado implementation law. In order to extract information from satellite images, the methodology proposed by Moreira (2011) was applied, which suggests an automatic software classification in the Geographical Information Systems (SIG), with visual interpretation. The maps generated from the classification of the APA Banhado were based on reference data from the years of 1995, 2000, 2005, 2010 and 2015. The results revealed conflicts between the environmental legislation and the land use, which prompted the possibility of generating basic data capable of incorporation into public planning policies and the preserved area environmental management, including a revision of concepts under the environmental preservation, as a future safety water reserve for the metropolitan region of the Paraíba Valley – SP.