scholarly journals SUN-137 Clonal Status of Multigland Disease Primary Hyperparathyroidism

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Pedram Azimzadeh ◽  
Yuhong Shi ◽  
Ace St. John ◽  
Janice ferlitch ◽  
John A Olson
Keyword(s):  
Primary Hyperparathyroidism ◽  
Fragment Analysis ◽  
Allele Distribution ◽  
Multiple Tumors ◽  
Clonal Relationship ◽  
Parathyroid Tumors ◽  
Software Classification ◽  
Relationship Of ◽  
Pure Poly

Abstract Primary hyperparathyroidism (PHPT) is a common endocrine disorder that arises due to single or multiple parathyroid gland disease (MGD). The molecular mechanism(s) of parathyroid neoplasia are incompletely understood and both monoclonal (mono-X) and polyclonal (poly-X) parathyroid tumors have been described using methylation-sensitive PCR of X-linked Human Androgen Receptor (HUMARA) alleles. Our previous investigations of parathyroid tumor clonal status has shown that poly-X tumors are common and are associated with MGD in patients with non-familial PHPT (Shi et al. 2014 & 2018). This work examined the clonal status of the dominant gland and the clonal relationship of multiple tumors from the same patient has not been examined. The goal of the current study was to determine the clonal relationship of parathyroid tumors from PHPT patients with MGD. Banked parathyroid tissues from twenty-nine PHPT patients with MGD were examined in this study. Clonal status (mono-X vs poly-X) of multiple abnormal parathyroid glands from each patient was determined using a modification of the HUMARA assay used in our prior work. Briefly, methylation-sensitive PCR of HUMARA alleles was performed followed by fragment analysis using Capillary-Electrophoresis performed. Raw fragment sizing data analyzed using Peak Scanner software. Classification of samples as either mon-X or poly-X was made as described in (Shattuck et al.) Of 29 PHPT patients with MGD, 13 (45%) had pure mono-X, 5 (17%) had pure poly-X, and 11 (38%) had a mixture of mono-X and poly-X tumors. Five of 29 patients had three or more abnormal glands evaluated: 3 had mixture of poly-X and mono-X, 2 had pure mono-X tumors, and none were pure polyclonal-X. Eighteen (62%) out of 29 patients had paired upper or lower double adenomas. Of these, 9 (50%) were pure mono-X, 4 were pure poly-X, and 5 were mixed mono-X/poly-X. In 2 patients with multiple mono-X tumors, allele distribution was not the same in different abnormal glands. Our previous work has demonstrated that among patients with non-familial PHPT, poly-X parathyroid tumors are common and are associated with MGD. Our new data extend these findings to show that the clonal relationship between multiple parathyroid tumors from the same patient is complex and may reflect the emergence of single or multiple tumors from a background of parathyroid hyperplasia, or other mechanism(s). Future studies to explore the mechanisms behind these apparent clonal relationships are warranted and ongoing. Reference: (1) Shi et al., PNAS 2014, 201319742. (2) Shi et al., Surgery 2018, 9-14. (3) Shattuck. N Engl J Med 2005, 2406-12.

Localization of Parathyroid Tumors Detected by Ultrasonography in Patients with Primary Hyperparathyroidism

Choonpa Igaku ◽  
2006 ◽  
Vol 33 (3) ◽  
pp. 323-327 ◽  
Author(s):  
Shinji MORITA ◽  
Yoshimi MIMURA ◽  
Hisashi OHTA ◽  
Shuuji FUKATA ◽  
Nobuyuki AMINO ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Parathyroid Tumors

scholarly journals Relationship of Hull Mesocarp Color to Seed Germination and Vigor in Large-Seeded Virginia-Type Peanuts

1995 ◽  
Vol 22 (1) ◽  
pp. 22-26 ◽  
Author(s):  
J. F. Spears ◽  
G. A. Sullivan
Keyword(s):  
Accelerated Aging ◽  
Dry Weight ◽  
Seed Moisture Content ◽  
Physiological Maturity ◽  
Seed Maturity ◽  
Seed Moisture ◽  
Arachis Hypogaea L ◽  
Maturity Class ◽  
Relationship Of

Abstract Classification of peanuts (Arachis hypogaea L.) based on pod mesocarp color has become a popular means of estimating maturity of runner peanuts. This study was initiated to determine if the hull mesocarp color is related to seed maturity of virginia-type peanuts and to evaluate changes in quality as seed mature. Cultivars NC 7 and NC 9 peanuts were harvested by hand in 1990, 1991, and 1992. Pods were separated according to mesocarp color. Seed moisture content and dry weight within a maturity class varied with cultivar and production year. Germination of NC 7 seed grown in 1990 and 1992 increased as seed approached maturity. Immature NC 9 seed grown in 1991 and 1992 had substantially lower germination than seed from mature pods. There was no increase in germination during maturation of NC 7 seed harvested in 1991 or NC 9 from 1990. Seed leakage during imbibition, measured by electrical conductivity, decreased as seed matured. The lowest leakage levels occurred when seed had reached physiological maturity. Germination following accelerated aging (AA) increased as seed matured. Maximum AA germination of NC 7 occurred when seed had reached 77, 84, and 100% of their final dry weight in 1990, 1991, and 1992, respectively. NC 9 seed achieved maximum germination following AA after the seed amassed at least 90% of their final dry weight.

scholarly journals The relationship of genetic factors to the development of nephrolithiasis in primary hyperparathyroidism

2015 ◽  
Author(s):  
Elena Peretokina ◽  
Natalia Mokrysheva ◽  
Lyudmila Rozhinskaya ◽  
Ekaterina Zakharova
Keyword(s):  
Primary Hyperparathyroidism ◽  
Genetic Factors ◽  
Relationship Of ◽  
The Relationship

GONADAL DYSGENESIS WITH XX-ISOCHROMOSOME CONSTITUTION AND ABNORMAL THYROID PATTERNS

1967 ◽  
Vol 54 (4) ◽  
pp. 609-617 ◽  
Author(s):  
R. G. Milet ◽  
E. R. Plunkett ◽  
D. H. Carr
Keyword(s):  
Autoimmune Disease ◽  
X Chromosome ◽  
Gonadal Dysgenesis ◽  
Ridge Count ◽  
Suppurative Otitis Media ◽  
Lyon Hypothesis ◽  
Relationship Of ◽  
The Relationship ◽  
Thyroid Abnormalities

ABSTRACT The authors report a female patient with XXi constitution for the long arm of the X chromosome associated with thyroid abnormalities, high digital ridge count and chronic suppurative otitis media. This is followed by a discussion of the correlation between genotype and phenotype, comment on the Lyon hypothesis, the relationship of thyroid abnormalities to this condition, autoimmune disease, unbalanced sex chromosomal constitution and the association with a high total digital ridge count. Finally a single hypothesis is proposed for the associated clinical entities that have been found and the suggestion that the classification of this particular type of gonadal dysgenesis be considered as a new syndrome, the »XX-isochromosome syndrome«.

Mutagenic Factors and Complex Clonal Relationship of Multifocal Urothelial Cell Carcinoma

2017 ◽  
Vol 71 (5) ◽  
pp. 841-843 ◽  
Author(s):  
Yiqing Du ◽  
Ruoyan Li ◽  
Zhanghua Chen ◽  
Xiaofeng Wang ◽  
Tao Xu ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Urothelial Cell ◽  
Urothelial Cell Carcinoma ◽  
Clonal Relationship ◽  
Relationship Of

SYSTEMIC LUPUS ERYTHEMATOSUS AND SYNDROMES POSSIBLY RELATED

PEDIATRICS ◽  
1957 ◽  
Vol 19 (6) ◽  
pp. 1109-1123
Author(s):  
M. A. Ogryzlo ◽  
H. A. Smythe
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Serum Proteins ◽  
Clinical Manifestations ◽  
Electrophoretic Pattern ◽  
Chemotherapeutic Agents ◽  
Systemic Lupus ◽  
Relationship Of ◽  
The Relationship

Attention is drawn to the difficulties that may be encountered in the positive identification and classification of many patients suspected of suffering from systemic lupus erythematosus. Much of this is due to a lack of specific criteria, either clinical or pathologic, for the diagnosis of the disease. The problem has been made more difficult by the recognition of a number of other syndromes that bear a superficial resemblance to systemic lupus erythematosus, yet differ in clinical manifestations, natural course, prognosis and other respects. A feature common to the group is the presence of the L.E. cell phenomenon. The related conditions differ from lupus enythematosus in that the L.E. phenomenon may only be demonstrable intermittently especially during severe exacerbations of the disease, while at the same time disturbances in the electrophoretic pattern of the serum proteins may be much more profound. In systemic rheumatoid disease the prognosis without steroid therapy is better than in systemic lupus erythematosus, although the morbidity may be great. The reactions which follow administration of certain chemotherapeutic agents are of considerable interest, particularly in view of the similarity to lupus erythematosus and rheumatoid arthritis, and the reversibility on withdrawal of the offending agent. The relationship of these syndromes to each other and to classical systemic lupus erythematosus has not yet been resolved, and inclusion of them under the diagnosis of systemic lupus erythematosus at this time must be regarded as premature.

Accounting theories and their impact on the formation and development of social expenditure accounting

2020 ◽  
pp. 251-258
Author(s):  
Vera Savchenko ◽  
◽  
Oleksandr Gai ◽  
Oksana Yurchenko ◽  
◽  
...  
Keyword(s):  
Social Development ◽  
Point Of View ◽  
Social Costs ◽  
Social Expenditure ◽  
Economic Theories ◽  
The Subject ◽  
Accounting Theory ◽  
Relationship Of ◽  
The Relationship

The article considers the essence of accounting theories, approaches to their separation, the relationship of accounting and economic theories, and the direction of development of accounting theories in accordance with the needs of economic and social development. The approaches to the classification of accounting theories are generalized, as well as the approaches to the interpretation of «accounting theory», the peculiarities of the interpretation of the subject of accounting from the point of view of different accounting theories are revealed and the objectivity of expansion of accounting objects is substantiated. In the context of the formation and development of accounting theories, the category of «social costs» is considered as an accounting object.

Description of new chiactine-bearing sponges provides insights into the higher classification of Calcaronea (Porifera: Calcarea)

Zootaxa ◽  
2019 ◽  
Vol 4615 (2) ◽  
pp. 201
Author(s):  
ADRIANA ALVIZU ◽  
JOANA R. XAVIER ◽  
HANS TORE RAPP
Keyword(s):  
New Species ◽  
Phylogenetic Reconstruction ◽  
Molecular Data ◽  
Phylogenetic Study ◽  
Two New Species ◽  
Close Relationship ◽  
New Material ◽  
Relationship Of ◽  
The Antarctic

A recent phylogenetic study revealed a close relationship between chiactine-bearing (family Achramorphidae, order Leucosolenida) and pugiole-bearing (order Baerida) calcaronean sponges as well as new putative taxa within Achramorphidae. In this study, we present a revision of chiactine-bearing sponges based on morphological re-examination of type material and recently collected specimens, in addition to new molecular data for the ribosomal 18S and C-region of the 28S. We provide re-descriptions for all known chiactine-bearing species, and further describe two new species from the Antarctic (Achramorpha antarctica sp. nov. and Megapogon schiaparellii sp. nov.) and two new species and a new genus from the Nordic Seas (Achramorpha ingolfi sp. nov. and Sarsinella karasikensis gen. nov. sp. nov.). The new phylogenetic reconstruction based on ribosomal 18S and C-region of the 28S confirms previous findings about the close relationship of some members of Baerida and the family Achramorphidae of the order Leucosolenida. However, new material and the addition of molecular data from the type species of both taxa would be required to formally propose changes at (sub-)ordinal levels within the classification of Calcaronean sponges. 

scholarly journals Are Virtual Particles Less Real?

Entropy ◽  
2019 ◽  
Vol 21 (2) ◽  
pp. 141 ◽  
Author(s):  
Gregg Jaeger
Keyword(s):  
Quantum Field ◽  
Interacting Particles ◽  
Virtual Particles ◽  
Quantum Particles ◽  
Action At A Distance ◽  
Relationship Of ◽  
The Relationship

The question of whether virtual quantum particles exist is considered here in light of previous critical analysis and under the assumption that there are particles in the world as described by quantum field theory. The relationship of the classification of particles to quantum-field-theoretic calculations and the diagrammatic aids that are often used in them is clarified. It is pointed out that the distinction between virtual particles and others and, therefore, judgments regarding their reality have been made on basis of these methods rather than on their physical characteristics. As such, it has obscured the question of their existence. It is here argued that the most influential arguments against the existence of virtual particles but not other particles fail because they either are arguments against the existence of particles in general rather than virtual particles per se, or are dependent on the imposition of classical intuitions on quantum systems, or are simply beside the point. Several reasons are then provided for considering virtual particles real, such as their descriptive, explanatory, and predictive value, and a clearer characterization of virtuality—one in terms of intermediate states—that also applies beyond perturbation theory is provided. It is also pointed out that in the role of force mediators, they serve to preclude action-at-a-distance between interacting particles. For these reasons, it is concluded that virtual particles are as real as other quantum particles.

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