Angiosarcoma of the Scalp: A Case Report

Angiosarcomas also called hemangioendothelia, are rare and highly malignant vascular tumors of mesodermal origin, they represent 08-10% of cancers and can affect any part of the body.Angiosarcoma mainly affects the skin, the face is the preferred topography in adults, it remains exceptional in children, with a predilection for the mediastinum and pericardium,The angiogenesis of angiosarcomas is still poorly understood; However, chronic lymphedema and exposure to prolonged radiotherapy are blamed. Total surgical excision is the treatment of choice in localized forms, followed by chemotherapy. pre- and post-operative radiotherapy may be necessary.New studies have shown the effectiveness of beta blockers (propranolol) in the management of angiosarcomas.The prognosis depends on the age of the patient, the size of the tumor, the histological grade and the extent of tumor progression.

Chromosome 8 Polysomy Accounting for MYC Over-Expression in Angiosarcoma Arising as Somatic-Type Malignancy in Metastatic Teratoma. Case Report

MYC over-expression by immunohistochemistry (IHC) is utilised in routine pathology practice as a surrogate marker for MYC amplification, which plays a key oncogenic role in post-irradiation and chronic lymphedema-associated angiosarcoma. We present the case of a 32-year old male, who presented with high-grade angiosarcoma arising in a background of metastatic testicular teratoma. IHC for MYC showed strong nuclear expression in the angiosarcoma cells prompting the consideration of post-irradiation-induced angiosarcoma but our patient did not undergo radiotherapy. Fluorescence in-situ hybridization (FISH) excluded MYC amplification and instead showed Chromosome 8 polysomy, which accounted for the strong MYC IHC expression present, not previously described in the context of germ cell tumours. The occurrence of MYC over-expression due to polysomy illustrates a novel clinical scenario (angiosarcoma arising as somatic malignancy) where strong MYC IHC expression can be found in the absence of underlying amplification or prior radiotherapy exposure.

Soft Tissue Tumor

Soft tissue tumors are a heterogeneous group of benign and malignant lesions that develop from a variety of nonepithelial, extraskeletal elements, including adipose tissue, smooth and skeletal muscle, tendons, cartilage, fibrous tissue, blood vessels, and lymphatic structures. The writing of this article includes various sources originating from scientific journals and government guidelines and related agencies. Source searches were carried out on online portals for journal publications such as Med Scape Google Scholar (scholar.google.com) and the National Centre for Biotechnology Information/NCBI (ncbi.nlm.nih.gov), with the keyword “Sensoric Nerve Trauma”. Soft tissue tumors (STT) can be benign or malignant, and benign soft tissue tumors are more common than malignant tumors with a ratio of 100: 1. In a study of 93 cases of soft tissue tumors, it was found that the incidence of benign tumors was 75.2% and malignant tumors were 24.8%. Soft tissue tumors are associated with genetic conditions, radiation, chronic lymphedema, environmental carcinogens, and infections.

Acceptance of Disability, Coping Style, Perceived Social Support and Quality of Life Among Patients With Chronic Lymphedema: a Cross-sectional Study

Objective: To examine acceptance of disability, coping style, perceived social support, and quality of life and to explore the relationships between acceptance of disability, coping style, perceived social support and quality of life among Chinese patients with chronic lymphedema.Methods: Chronic lymphedema patients were recruited from five tertiary hospitals between May and July 2020 in China. Recruited patients were assessed for quality of life (QOL), acceptance of disability (AOD), coping styles, perceived social support (PSS), and sociodemographic and disease-related factors. Multivariate linear regression models were conducted to examine the multivariate effect of AOD, coping style, PSS, and sociodemographic and disease-related factors on QOL.Results: A total of 163 chronic lymphedema patients were recruited. The mean score of QOL was 2.23 (SD=0.68). AOD, number of symptoms, acceptance-resignation, avoidance, degree of pain, PSS, and educational level were found to be significant predictors of QOL.Conclusion: Chinese patients with chronic lymphedema had moderate levels of QOL. The QOL and specific domains of patients were affected by different factors. Special attention and targeted interventions should be given to improve patients’ QOL.

GIANT SOLITARY CUTANEOUS ANGIOSARCOMA OF THE FOREARM OCCURRING OUTSIDE THE SETTING OF LYMPHEDEMA

Angiosarcoma (AS) is an aggressive vascular malignancy that can affect various anatomic sites. Although rare, cutaneous angiosarcoma (CAS) is the most common clinical manifestation of AS, accounting for approximately 50% to 60% of all AS. CAS is typically known to occur in three settings: (1) idiopathic, (2) following radiation treatment, or (3) is classically diagnosed following mastectomy with subsequent chronic lymphedema (known as Stewart Treves syndrome). We present a case of CAS on the forearm in a man with no history of lymphedema or radiation therapy, highlighting the necessity to discuss this diagnosis even outside the setting of conventional angiosarcomas.