Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

To modulate the biofunctionality of implantable medical devices commonly used in clinical practice, their surface modification with bioactive polymeric coatings is an attractive and successful emerging strategy. Biodegradable coatings based on poly(lactic acid-co-glycolic acid), PLGA, represent versatile and safe candidates for surface modification of implantable biomaterials and devices, providing additional tunable ability for topical delivery of desired therapeutic agents. In the present study, Ibuprofen-loaded PLGA coatings (PLGA/IBUP) were obtained by using the dip-coating and drop-casting combined protocol. The composite materials demonstrated long-term drug release under biologically simulated dynamic conditions. Reversible swelling phenomena of polymeric coatings occurred in the first two weeks of testing, accompanied by the gradual matrix degradation and slow release of the therapeutic agent. Irreversible degradation of PLGA coatings occurred after one month, due to copolymer’s hydrolysis (evidenced by chemical and structural modifications). After 30 days of dynamic testing, the cumulative release of IBUP was ~250 µg/mL. Excellent cytocompatibility was revealed on human-derived macrophages, fibroblasts and keratinocytes. The results herein evidence the promising potential of PLGA/IBUP coatings to be used for surface modification of medical devices, such as metallic implants and wound dressings.

Postharvest conservation of Tommy atkins mango fruits during storage using Moringa oleifera oil-based coating

Among several biodegradable coatings used to extend the shelf life of fresh fruits, those that can be obtained from Moringa oleifera stand out due to their extraordinary biochemical, antibacterial and antifungal properties. Another aspect is their constitution which is composed of proteins, lipids, carbohydrates, carotenoids, vitamins, minerals and natural bioactive compounds, that can be applied for the development of functional foods due to their nutritional and pharmaceutical properties. The objective of this study was to evaluate the effect of bio-based coating produced from different concentrations of Moringa oleifera seed oil added to cassava starch in the postharvest conservation of Tommy atkins mango fruits. The bio-based coating was applied to mango fruits stored at room temperature (27 °C) for 15 days. Mangoes were submitted to the following treatments: moringa oil (Moringa oleifera) in 4 concentrations: 0.5% (v/v) + cassava starch; 1% (v/v) + cassava starch; 1.5% (v/v) + cassava starch and a control treatment without coating (0%), during 15 days of storage (0, 3, 6, 9, 12 and 15 days), adding up to 24 treatments with three replications. The application of moringa-oil-based coating prolonged the postharvest shelf life of the Tommy atkins mango by maintaining the physicochemical and physical properties during 12 days of storage at room temperature when compared to control treatment. M. oleifera oil-based coatings delayed the degradation of the pigments, making the bio-coated fruits gain shine and remain with it

Effect of biodegradable coatings on the shelf life of Hancornia speciosa

ABSTRACT The production of Hancornia speciosa Gomes, in Brazil, has increased significantly in recent years, with a concomitant increase in post-harvest losses, making it important to find out new techniques that contribute to extend the shelf life of this fruit without altering its physical, sensory and nutritional characteristics. The present study aimed to apply biodegradable coatings made from chitosan, whey protein, lactic acid and cassava starch to H. speciosa, as well as to assess their efficiency on the shelf life of the fruits. For that, physico-chemical analyses were performed to determine the pH, acidity, ºBrix, phenolic compounds, vitamin C and moisture content. The coatings with 1 % of chitosan, 4 % of whey protein, 3 % of cassava starch and 1.5 % of lactic acid presented satisfactory results at ambient temperature (25 ºC), delaying the ripening process, when compared to the controls.

Characterization of starch from different non-traditional sources and its application as coating in ‘Palmer’ mango fruit

ABSTRACT Yam, cassava, jackfruit seed and mango seed kernel have potential for the extraction and use as starch in the food industry of starch or for the formulation of biodegradable coatings. As a biodegradable coating, starch can be applied in fruits characterized by a fast maturation, such as mango, which requires technologies to increase its shelf life. The aim of this study was to characterize starch from four non-traditional sources and to evaluate their potential as coating for ‘Palmer’ mango fruit. Starches used were extracted from cassava, mango seed kernel, jackfruit seed, and yam, and had their physical, optical, and chemical properties characterized for later use as coatings of ‘Palmer’ mango fruit. Fruits were coated with 3% cassava starch, 3.5% jackfruit seed starch, 3.5% mango seed kernel starch and 3.5% yam starch, and were compared to the control (uncoated). They were then stored at 24.4 ± 0.3 °C and 87 ± 2% RH and evaluated for 12 days. A 5x7 factorial arrangement in a completely randomized experimental design was adopted. Total starch content was higher than 70% in the four sources of starch. Starches from jackfruit and yam had higher amylose content. The four sources of starch had low water solubility and swelling power, with jackfruit seed starch having the highest values. The coating sources were effective in maintaining quality, particularly mango seed kernel starch because it reduced respiratory rate and weight loss in 27.7% and 33.8%, respectively, as well as jackfruit seed starch as it delayed fruit skin yellowing.

Application of chitosan-based wound coatings ‘ChitoPran’ in the treatment of patients with burn trauma

Introduction The analysis of clinical experience for using biodegradable wound coating based on «HitoPran» chitosan in treatment of patients with burn trauma is presented.Background Our work included an analysis of clinical experience for using a biodegradable wound coating based on «HitoPran» chitosan for surgical treatment in patients with local and common thermal burns.Material and Methods A treatment analysis was conducted in 46 male and female patients, aged from 1 to 63 years with thermal burns on an area of 5 to 56% of the body surface. All injured were given surgical treatment in the complex with the use of low-temperature air plasma of arc discharge with atmospheric pressure in the conditions of our burn center in 2017-2018. Depending on the area and depth of the lesion, the patients were divided into two clinical groups: with local burns of II degree and area to 5% of the body surface and common burns of II and III degree and body surface 10% and more. In the course of early surgical treatment in patients with local border burns, the use of the wound coating «HitoPran» allows to achieve spontaneous epithelialization of wounds in dry environment after dermabrasion or escharotomy within the surface layers of dermis due to chitosan adhesion to the wound bottom, to reduce the number of dressings in the postoperative period. Covering skin grafts with perforation index 1:4 and 1:6 with wound «ChitoPran» coating in case of autodermoplasty in deep burn wounds provides satisfactory cellular epithelialization, reduces risk of regression of grafts, reduces consumption of wound coating and dressing material.Conclusion Application of Russian modern biodegradable coatings based on «HitoPran» chitosan in complex treatment in patients with local and common burns with different depth allows to optimize local treatment of burn injuries, as well as to reduce the cost of used dressing material in comparison with foreign alternatives.