When spider webs unite, they can tie up a lion1: NLM’s work in Information Technology and Health in Africa, 1997–2011

In 1997, Donald A.B. Lindberg M.D., Director, U.S. National Library of Medicine (NLM) agreed to address the request of African malaria researchers for access to the Internet and medical journals as part of the U.S. National Institutes of Health’s (NIH) contribution to the Multilateral Initiative on Malaria (MIM). This challenge matched my interests and previous experience in Africa. I joined NLM in 1997 to help establish the MIM Communications Network (MIMCom) in partnership with several NIH components and more than 30 other partners in Africa, the U.S., the United Kingdom (U.K.), and Europe. After a successful launch of MIMCom, NLM worked with African partners to create a series of innovative programs to build capacity in Africa and enhance global access to indigenous African research.

Solubility Enhancement of Antihyperlipidemic Drug by Solvent Diffusion Technique

Poor aqueous solubility of drugs is major limiting factor with many new drugs in their successful launch in market in spite of their potential pharmacokinetic activity. Therefore, poor solubility is critical factor if the molecule is to survive the pharmaceutical development process. In the current work, it was planned to enhance the solubility of antihyperlipidemic drug by solvent diffusion technique. For this the drug clofibrate and excipients were procured and spherical agglomerates were prepared and evaluated. The findings of the study states the novelty the hypothesis. Keywords: Solubility, Diffusion, Agglomerates

1205 Clinical Audit Demonstrating an Increase in Referrals to The Ophthalmology AMD Clinic at University Hospital Southampton

Aim To demonstrate if the introduction of OCT imaging by a national optician chain across its 740 stores in UK (followed by other chains) would increase in referrals to the wet AMD clinic. Secondly to assess if the direct increase of referrals would have an impact on the clinic workload. Method Retrospective review of all referrals made to the AMD service via optometrists/opticians throughout 2018. Total numbers of referrals that were proven to have nAMD requiring injections Inclusion; direct optician referral or GP referral via an optician. Exclusions: Ophthalmologist, Eye Casualty, other clinics and nAMD not requiring injections. Results Opticians were responsible for 62.88% (566) referrals out of 900 to the AMD service The second half of 2018 showed an increase in referrals (130 more) but with improved quality since the diagnostic accuracy of the optometrists increased from 22.94% to 37.64% The improved diagnostic accuracy of the optometrists was found to be statistically significant (Fisher’s exact test: p < 0.0003) Discussion Increase in patients requiring injections directly increases clinic by initial screen and follow up injections. Medical retina departments faced an increase in false positive referrals. Potentially due to seeing essentially normal findings in a new way (B scan) that are artefacts or misinterpretation of either the image or the normative values Conclusions Upon review and presentation of the audit, NHS will invest in an electronic referral system to aid the clinic. Education and ongoing clinical training are essential to the successful launch of an OCT service in the community.

Characterization of dark current signal measurements of the ACCDs used on board the Aeolus satellite

Even just shortly after the successful launch of the European Space Agency satellite Aeolus in August 2018, it turned out that dark current signal anomalies of single pixels (so-called “hot pixels”) on the accumulation charge-coupled devices (ACCDs) of the Aeolus detectors detrimentally impact the quality of the aerosol and wind products, potentially leading to wind errors of up to several meters per second. This paper provides a detailed characterization of the hot pixels that occurred during the first 1.5 years in orbit. The hot pixels are classified according to their characteristics to discuss their impact on wind measurements. Furthermore, mitigation approaches for the wind retrieval are presented and potential root causes for hot pixel occurrence are discussed. The analysis of the dark current signal anomalies reveals a large variety of anomalies ranging from pixels with random telegraph signal (RTS)-like characteristics to pixels with sporadic shifts in the median dark current signal. Moreover, the results indicate that the number of hot pixels almost linearly increased during the observing period between 2 September 2018 and 20 May 2020 with 6 % of the ACCD pixels affected in total at the end of the period leading to 9.5 % at the end of the mission lifetime. This work introduces dedicated instrument calibration modes and ground processors, which allowed for a correction shortly after a hot pixel occurrence. The achieved performance with this approach avoids risky adjustments to the in-flight hardware operation. It is demonstrated that the success of the correction scheme varies depending on the characteristics of each hot pixel itself. With the herein presented categorization, it is shown that multi-level RTS pixels with high fluctuation are the biggest challenge for the hot pixel correction scheme. Despite a detailed analysis in this framework, no conclusion could be drawn about the root cause of the hot pixel issue.

Flow Past Spherical Pipeline Inspection Gadgets in an Automated Launching System

Pipeline inspection gadgets (PIGs) are routinely used in pipeline maintenance, cleaning, and inspection. A fundamental understanding of the fluid flow around the PIG and consequently its impact on the operation is however still lacking. The surrounding flow and the dynamics of the PIG vary significantly based on the PIG shape and orientation to flow. Previous studies of PIG motion typically employed empirical experimental or reduced numerical data to extrapolate PIG velocities and pressure drops along the pipeline - while this could resolve issues specific to the case being studied, it does not go very far in developing an overall understanding of the dynamics of the system. Our study aims at analyzing a range of configurations for spherical PIGs in a natural gas pipeline to analyze flow patterns around them and determine their impact on PIG motion. Given the nature of the automated launcher analyzed, we carry out U-RANS simulations of a section of the launcher assembly, including the PIG in its initial position, at different field operating conditions. We simulate this setup for both single and multiple PIGs to determine alterations in the flow for a given launch sequence and outline the limitations of the setup. We then use the results from these simulations to determine the optimum configuration for a successful launch.

Analgesia for Sheep in Commercial Production: Where to Next?

Increasing societal and customer pressure to provide animals with ‘a life worth living’ continues to apply pressure on livestock production industries to alleviate pain associated with husbandry practices, injury and illness. Over the past 15–20 years, there has been considerable research effort to understand and develop mitigation strategies for painful husbandry procedures in sheep, leading to the successful launch of analgesic approaches specific to sheep in a number of countries. However, even with multi-modal approaches to analgesia, using both local anaesthetic and non-steroidal anti-inflammatory drugs (NSAID), pain is not obliterated, and the challenge of pain mitigation and phasing out of painful husbandry practices remains. It is timely to review and reflect on progress to date in order to strategically focus on the most important challenges, and the avenues which offer the greatest potential to be incorporated into industry practice in a process of continuous improvement. A structured, systematic literature search was carried out, incorporating peer-reviewed scientific literature in the period 2000–2019. An enormous volume of research is underway, testament to the fact that we have not solved the pain and analgesia challenge for any species, including our own. This review has highlighted a number of potential areas for further research.

The EUMETSAT Polar System - 13+ Successful Years of Global Observations for Operational Weather Prediction and Climate Monitoring

After successful launch in November 2018 and successful commissioning of Metop-C, all three satellites of the EUMETSAT Polar System (EPS) are in orbit together and operational. EPS is part of the Initial Joint Polar System (IJPS) with the US (NOAA) and provides the service in the mid-morning orbit. The Metop satellites carry a mission payload of sounding and imaging instruments, which allow provision of support to operational meteorology and climate monitoring which are the main mission objectives for EPS. Applications include Numerical Weather Prediction, atmospheric composition monitoring, and marine meteorology. Climate monitoring is supported through the generation of long time series through the program duration of 20+ years. The payload was developed and contributed by partners, including NOAA, CNES, and ESA. EUMETSAT and ESA developed the space segment in cooperation. The system has proven its value since the first satellite Metop-A, with enhanced products at high reliability for atmospheric sounding, delivered a very strong positive impact on NWP and results beyond expectations for atmospheric composition and chemistry applications. Having multiple satellites in orbit - now three, has enabled enhanced and additional products with increased impact, like atmospheric motion vector products at latitudes not accessible to geostationary observations or increased probability of radio-occultations and hence atmospheric soundings with the GRAS instruments. The paper gives an overview on the system, the embarked payload and discusses the benefits of generated products for applications and services. The conclusions point to the follow-on system, currently under development and assuring continuity for another 20+ years.

Characterization of the in-flight spectral response function of Geostationary Environment Monitoring Spectrometer (GEMS) retrieved using observed solar irradiance

<p>The successful launch of Geostationary Environment Monitoring Spectrometer (GEMS) onboard the Geostationary Korea Multipurpose Satellite 2B (GK-2B) opens up a new possibility to provide daily air quality information for trace gases and aerosols over East Asia with high spatiotemporal resolution. As a part of major efforts to calibrate and validate the performance of the GEMS, accurate characterization of the spectral response functions (SRFs) is critical. The characteristics of preflight SRFs examined in terms of shape, width, skewness, and kurtosis vary smoothly along both the spectral and spatial direction thanks to highly symmetrical optic system of GEMS. While the preflight SRFs are determined with high accuracy, there is possibility of changes of in-flight SRFs during the harsh launch processes and/or operations over the mission lifetime. Thus, it is important to verify the in-flight SRFs after launch and to continue monitoring of their variability over time to assure the reliable trace gases retrievals. Here, we retrieve the in-flight SRFs for all spectral and spatial domain of the GEMS using spectral fitting of observed daily solar measurement and high-resolution solar reference spectrum. A variety of analytic model functions including hybrid form of Gaussian and flat-topped function, asymmetric super Gaussian, Voigt function are tested to determine the best representative function for GEMS SRF. The SRFs retrieved from early solar irradiances measured during the in-orbit tests agree well with the preflight SRFs indicating that no significant change occurred during the launch process. Continuous monitoring of the in-flight SRF is planned, using daily solar irradiances to investigate the temporal variation along with spectral and spatial directions. The detailed results of the in-flight SRF retrieval are to be presented.</p>

Drug Resistance and Novel Therapies in Cancers in 2019

After the successful launch in the second half of 2018 by Cancers, the topic collection “Drug Resistance and Novel Therapies in Cancers” experienced its productive first full year in 2019 [...]

The Unique Role of the Jason Geodetic Missions for high Resolution Gravity Field and Mean Sea Surface Modelling

The resolutions of current global altimetric gravity models and mean sea surface models are around 12 km wavelength resolving 6 km features, and for many years it has been difficult to improve the resolution further in a systematic way. For both Jason 1 and 2, a Geodetic Mission (GM) has been carried out as a part of the Extension-of-Life phase. The GM for Jason-1 lasted 406 days. The GM for Jason-2 was planned to provide ground-tracks with a systematic spacing of 4 km after 2 years and potentially 2 km after 4 years. Unfortunately, the satellite ceased operation in October 2019 after 2 years of Geodetic Mission but still provided a fantastic dataset for high resolution gravity recovery. We highlight the improvement to the gravity field which has been derived from the 2 years GM. When an Extension-of-Life phase is conducted, the satellite instruments will be old. Particularly Jason-2 suffered from several safe-holds and instrument outages during the GM. This leads to systematic gaps in the data-coverage and degrades the quality of the derived gravity field. For the first time, the Jason-2 GM was “rewound” to mitigate the effect of the outages, and we evaluate the effect of “mission rewind” on gravity. With the recent successful launch of Sentinel-6 Michael Freilich (S6-MF, formerly Jason CS), we investigate the possibility creating an altimetric dataset with 2 km track spacing as this would lead to fundamental increase in the spatial resolution of global altimetric gravity fields. We investigate the effect of bisecting the ground-tracks of existing GM to create a mesh with twice the resolution rather than starting all over with a new GM. The idea explores the unique opportunity to inject Jason-3 GM into the same orbital plane as used for Jason-2 GM but bisecting the existing Jason-2 tracks. This way, the already 2-years Jason-2 GM could be used to create a 2 km grid after only 2 years of Jason-3 GM, rather than starting all over with a new GM for Jason-3.