Sex-specific effect of maternal thyroid hormone trajectories on preschoolers’ behavioral development: a birth cohort study

2022 ◽  
Author(s):  
Peixuan Li ◽  
Yuzhu Teng ◽  
Xue Ru ◽  
Zijian Liu ◽  
Yan Han ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Aggressive Behavior ◽  
Birth Cohort ◽  
Child Behavior Checklist ◽  
Specific Effect ◽  
Behavioral Development ◽  
Birth Cohort Study ◽  
Preschool Boys ◽  
Maternal Thyroid ◽  
And Child Health

Abstract Context Maternal thyroid hormone trajectories are better predictor of offspring’s neurodevelopment than hormone levels in single trimester of pregnancy. Programming effect of uterine hormonal environment on offspring’s health is usually sex-specific. Objective To examine the sex-specific effect of thyroid hormone trajectories on preschoolers’ behavioral development. Design Based on Ma’ anshan Birth Cohort (MABC) in China, pregnant women were recruited at their first antenatal checkup from May 2013 to September 2014. Setting Ma’ anshan Maternal and Child Health Hospital in China. Patients or Other Participants 1860 mother-child pairs were included in the analysis. Children were followed up at age of 4. Main Outcome Measures Maternal thyroid hormones (TSH, FT4) and TPOAb in the first, second and third trimesters of pregnancy were retrospectively assayed. Preschoolers’ behavioral development was assessed by Achenbach Child Behavior Checklist (CBCL/1.5~5). Results Maternal TSH and FT4 levels were respectively fitted into high, moderate and low trajectories. In boys, maternal high TSH trajectory was related to withdrawn (OR = 2.01, 95% CI: 1.16, 3.50) and externalizing problems (OR = 2.69, 95% CI: 1.22, 5.92), and moderate TSH trajectory was associated with aggressive behavior (OR = 3.76, 95% CI: 1.16, 12.23). Maternal high FT4 trajectory was associated with anxious/depressed (OR = 2.22, 95% CI: 1.08, 4.56) and total problems (OR = 1.74, 95% CI: 1.13, 2.66), and low FT4 trajectory was associated with aggressive behavior (OR = 4.17, 95% CI: 1.22, 14.24). Conclusions Maternal thyroid hormone trajectories impact preschool boys’ behavioral development.

scholarly journals Cohort profile: the Maternal and Child Health and Nutrition in Acre, Brazil, birth cohort study (MINA-Brazil)

BMJ Open ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. e034513
Author(s):  
Marly A Cardoso ◽  
Alicia Matijasevich ◽  
Maira Barreto Malta ◽  
Barbara Hatzlhoffer Lourenco ◽  
Suely G A Gimeno ◽  
...  
Keyword(s):  
Child Health ◽  
Birth Cohort ◽  
Maternal And Child Health ◽  
Retention Rate ◽  
Epidemiological Data ◽  
Childhood Development ◽  
Birth Cohort Study ◽  
Health And Nutrition ◽  
And Child Health

PurposeMaternal and Child Health and Nutrition in Acre, Brazil (MINA-Brazil) is a longitudinal, prospective population-based birth cohort, set-up to understand the effects of early environmental exposures and maternal lifestyle choices on growth and development of the Amazonian children.ParticipantsMother–baby pairs (n=1246) were enrolled at delivery from July 2015 to June 2016 in Cruzeiro do Sul, Acre, Brazil. Mothers of 43.7% of the cohort were recruited in the study during pregnancy from February 2015 to January 2016. Study visits took place during pregnancy, delivery, at 1 month, 6 months, 1 year and 2 years after delivery. In addition to clinical and epidemiological data, samples collected by the MINA-Brazil study include plasma, serum and extracted DNA from blood and faeces, which are stored in a biobank.Findings to dateKey baseline reports found a high prevalence of gestational night blindness (11.5%; 95% CI 9.97% to 13.25%) and maternal anaemia (39.4%; 95% CI 36.84% to 41.95%) at delivery. Antenatal malaria episodes (74.6% ofPlasmodium vivax) were diagnosed in 8.0% of the women and were associated with an average reduction in birth weight z-scores of 0.35 (95% CI 0.14 to 0.57) and in birth length z-scores of 0.31 (95% CI 0.08 to 0.54), compared with malaria-free pregnancies. At 2-year follow-up, data collection strategies combined telephone calls, WhatsApp, social media community and home visits to minimise losses of follow-up (retention rate of 79.5%).Future plansA 5-year follow-up visit is planned in 2021 with similar interviews and biospecimens collection. The findings from this prospective cohort will provide novel insights into the roles of prenatal and postnatal factors in determining early childhood development in an Amazonian population.

Impact of maternal thyroid autoantibodies positivity on the risk of early term birth: Ma’anshan Birth Cohort Study

Endocrine ◽  
2018 ◽  
Vol 60 (2) ◽  
pp. 329-338 ◽  
Author(s):  
Yan Han ◽  
Lei-Jing Mao ◽  
Xing Ge ◽  
Kun Huang ◽  
Shuang-Qin Yan ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Cohort ◽  
Birth Cohort Study ◽  
Thyroid Autoantibodies ◽  
Term Birth ◽  
Early Term ◽  
Maternal Thyroid

scholarly journals Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Hong Liang ◽  
Ziliang Wang ◽  
Maohua Miao ◽  
Youping Tian ◽  
Yan Zhou ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Cord Blood ◽  
Birth Cohort ◽  
Prenatal Exposure ◽  
Perfluoroalkyl Substances ◽  
Birth Cohort Study ◽  
Free T4 ◽  
Cord Plasma ◽  
Fetal Thyroid

Abstract Background Evidence of associations between prenatal exposure to perfluoroalkyl substances (PFASs) and fetal thyroid hormones (THs) is controversial, and few studies have estimated the associations, while addressing the high correlations among multiple PFASs. We aimed to examine the associations between prenatal PFAS exposure and thyroid hormone concentrations in cord blood. Methods A total of 300 mother-infant pairs from the Shanghai-Minhang Birth Cohort Study were included. We measured the concentrations of eight PFASs in maternal plasma samples collected at 12–16 gestational weeks, as well as those of total thyroxine (T4), free T4 (FT4), total triiodothyronine (T3), free T3 (FT3), and thyroid stimulating hormone (TSH) in cord plasma. We estimated the associations between maternal PFAS concentrations and TH concentrations using linear regression and Bayesian kernel machine regression (BKMR) models. Results In BKMR models, higher PFAS mixture concentrations were associated with increased T3 concentrations, and there were suggestive associations with increased FT3 concentrations. For single-exposure effects in BKMR models, a change in PFDA, PFUdA, and PFOA concentrations from the 25th to 75th percentile was associated with a 0.04 (95%CrI: − 0.01, 0.09), 0.02 (95%CrI: − 0.03, 0.07), and 0.03 (95%CrI: − 0.001, 0.06) nmol/L increase in T3 concentrations, respectively. PFOA, PFNA, and PFDA were the predominant compounds in PFASs-FT3 associations, and the corresponding estimates were 0.11 (95% CrI: 0.02, 0.19), − 0.17 (95% CrI: − 0.28, − 0.07), and 0.12 (95% CrI: − 0.004, 0.24) pmol/L, respectively. A change in PFNA and PFOA concentrations from the 25th to 75th percentile was associated with a − 1.69 (95% CrI: − 2.98, − 0.41) μIU/mL decrease and a 1.51 (95% CrI: 0.48, 2.55) μIU/mL increase in TSH concentrations. The associations of PFOA and PFNA with T3/FT3 were more pronounced in boys, while those with TSH were more pronounced in girls. Conclusion Our results suggest that prenatal exposure to multiple PFASs was associated with thyroid hormones in cord blood. However, individual PFAS had varied effects—differing in magnitude and direction—on fetal thyroid hormones.

Emotional and behavioural antecedents of young adults who screen positive for non-affective psychosis: a 21-year birth cohort study

2008 ◽  
Vol 39 (4) ◽  
pp. 625-634 ◽  
Author(s):  
J. Welham ◽  
J. Scott ◽  
G. Williams ◽  
J. Najman ◽  
W. Bor ◽  
...  
Keyword(s):  
Young Adults ◽  
Birth Cohort ◽  
Child Behavior Checklist ◽  
Composite International Diagnostic Interview ◽  
Social Attention ◽  
Clinical Syndrome ◽  
Self Report ◽  
Birth Cohort Study ◽  
Childhood And Adolescence ◽  
Affective Psychosis

BackgroundBirth cohort studies have shown that individuals who develop non-affective psychoses display subtle deviations in behaviour during childhood and adolescence. We had the opportunity to examine the widely used Child Behavior Checklist (CBCL) and the Youth Self-Report (YSR) to explore the antecedents of non-affective psychosis.MethodBased on a birth cohort of 3801 young adults, psychopathology was assessed at years 5 and 14 using the CBCL and/or the YSR. Screen-positive non-affective psychosis (SP-NAP) was assessed at year 21 by using the Composite International Diagnostic Interview (CIDI) or a self-report checklist. The association between childhood symptoms and SP-NAP was examined using logistic regression.ResultsOf the cohort, 60 subjects were classified as SP-NAP. In males, SP-NAP was associated with higher scores: (a) on year 5 CBCL ‘Total’, ‘Aggression’ and ‘Social, Attention and Thought’ scores; (b) on year 14 CBCL ‘Social’, ‘Attention’ and ‘Delinquency’ scores, and (c) YSR ‘Total’ and many YSR subscores. These associations were less clear for females. Hallucinations at year 14 were associated with SP-NAP for both sexes. Boys with high ‘Total’ scores at both years 5 and 14 were at greatest risk of SP-NAP (a 5-fold risk), followed by boys and girls whose ‘Social, Attention and Thought’ scores either increased or remained high from years 5 to 14 (3- to 13-fold risk).ConclusionsIndividuals who screen positive for non-affective psychosis show increased psychopathology during childhood and adolescence. The psychopathological trajectory of children who go on to develop schizophrenia anticipates the heterogeneity associated with the full clinical syndrome.

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